FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087975767> ?p ?o ?g. }

• W3087975767 endingPage "255" @default.
• W3087975767 startingPage "247" @default.
• W3087975767 abstract "To evaluate the association between the degree of response to placebo in migraine studies and the observed difference between drug and placebo across studies of preventative treatments for migraine.A systematic review was performed using MEDLINE and the Cochrane Central Register of Controlled Clinical Trials from January 1988 to June 2019. Randomized, double-blind, parallel-group, placebo-controlled trials on oral or injection preventative treatments for migraine were included. Single- and multi-variable linear regression analyses were performed on the placebo-subtracted response rate (i.e. placebo responders subtracted from active responders), and the proportion of placebo responders. Fisher's exact tests were performed on the level of placebo response and the success in meeting the study's primary endpoint.After adjusting for route of administration and number of randomized subjects, there was a statistically significant association between the proportion of patients who were placebo responders and the placebo-subtracted response rate (b = -0.27, p = 0.02). There was a statistically significant difference in trial success rate (60%) between studies with ≤20% placebo responders and studies with > 30% placebo responders (p = 0.03).Considering the detrimental impact that high placebo response can have on clinical trials, it is imperative to find effective solutions to decrease the placebo response and increase assay sensitivity." @default.
• W3087975767 created "2020-10-01" @default.
• W3087975767 creator A5001265546 @default.
• W3087975767 creator A5015619845 @default.
• W3087975767 creator A5058996817 @default.
• W3087975767 creator A5059824642 @default.
• W3087975767 date "2020-09-22" @default.
• W3087975767 modified "2023-10-18" @default.
• W3087975767 title "The relation between the placebo response, observed treatment effect, and failure to meet primary endpoint: A systematic review of clinical trials of preventative pharmacological migraine treatments" @default.
• W3087975767 cites W1966615063 @default.
• W3087975767 cites W1971350230 @default.
• W3087975767 cites W1974501762 @default.
• W3087975767 cites W1986404370 @default.
• W3087975767 cites W1992092866 @default.
• W3087975767 cites W1997154366 @default.
• W3087975767 cites W2016030981 @default.
• W3087975767 cites W2026080368 @default.
• W3087975767 cites W2035354360 @default.
• W3087975767 cites W2040745597 @default.
• W3087975767 cites W2056550385 @default.
• W3087975767 cites W2056755600 @default.
• W3087975767 cites W2062838995 @default.
• W3087975767 cites W2064607382 @default.
• W3087975767 cites W2078127859 @default.
• W3087975767 cites W2084811617 @default.
• W3087975767 cites W2098923148 @default.
• W3087975767 cites W2118912931 @default.
• W3087975767 cites W2127880532 @default.
• W3087975767 cites W2137787323 @default.
• W3087975767 cites W2148445312 @default.
• W3087975767 cites W2153403353 @default.
• W3087975767 cites W2162978878 @default.
• W3087975767 cites W2268603990 @default.
• W3087975767 cites W2270371209 @default.
• W3087975767 cites W2332448947 @default.
• W3087975767 cites W2341353168 @default.
• W3087975767 cites W2347737266 @default.
• W3087975767 cites W2590226609 @default.
• W3087975767 cites W2768357559 @default.
• W3087975767 cites W2770965214 @default.
• W3087975767 cites W2792811290 @default.
• W3087975767 cites W2803715733 @default.
• W3087975767 cites W2804308748 @default.
• W3087975767 cites W2805181790 @default.
• W3087975767 cites W2805937849 @default.
• W3087975767 cites W2901687990 @default.
• W3087975767 cites W2920516862 @default.
• W3087975767 cites W2970814103 @default.
• W3087975767 cites W2990660492 @default.
• W3087975767 cites W4294215472 @default.
• W3087975767 doi "https://doi.org/10.1177/0333102420960020" @default.
• W3087975767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32960658" @default.
• W3087975767 hasPublicationYear "2020" @default.
• W3087975767 type Work @default.
• W3087975767 sameAs 3087975767 @default.
• W3087975767 citedByCount "5" @default.
• W3087975767 countsByYear W30879757672021 @default.
• W3087975767 countsByYear W30879757672022 @default.
• W3087975767 countsByYear W30879757672023 @default.
• W3087975767 crossrefType "journal-article" @default.
• W3087975767 hasAuthorship W3087975767A5001265546 @default.
• W3087975767 hasAuthorship W3087975767A5015619845 @default.
• W3087975767 hasAuthorship W3087975767A5058996817 @default.
• W3087975767 hasAuthorship W3087975767A5059824642 @default.
• W3087975767 hasConcept C126322002 @default.
• W3087975767 hasConcept C142724271 @default.
• W3087975767 hasConcept C168563851 @default.
• W3087975767 hasConcept C203092338 @default.
• W3087975767 hasConcept C204787440 @default.
• W3087975767 hasConcept C27081682 @default.
• W3087975767 hasConcept C2778541695 @default.
• W3087975767 hasConcept C2992459003 @default.
• W3087975767 hasConcept C42219234 @default.
• W3087975767 hasConcept C535046627 @default.
• W3087975767 hasConcept C71924100 @default.
• W3087975767 hasConcept C95190672 @default.
• W3087975767 hasConceptScore W3087975767C126322002 @default.
• W3087975767 hasConceptScore W3087975767C142724271 @default.
• W3087975767 hasConceptScore W3087975767C168563851 @default.
• W3087975767 hasConceptScore W3087975767C203092338 @default.
• W3087975767 hasConceptScore W3087975767C204787440 @default.
• W3087975767 hasConceptScore W3087975767C27081682 @default.
• W3087975767 hasConceptScore W3087975767C2778541695 @default.
• W3087975767 hasConceptScore W3087975767C2992459003 @default.
• W3087975767 hasConceptScore W3087975767C42219234 @default.
• W3087975767 hasConceptScore W3087975767C535046627 @default.
• W3087975767 hasConceptScore W3087975767C71924100 @default.
• W3087975767 hasConceptScore W3087975767C95190672 @default.
• W3087975767 hasIssue "2" @default.
• W3087975767 hasLocation W30879757671 @default.
• W3087975767 hasLocation W30879757672 @default.
• W3087975767 hasOpenAccess W3087975767 @default.
• W3087975767 hasPrimaryLocation W30879757671 @default.
• W3087975767 hasRelatedWork W175650903 @default.
• W3087975767 hasRelatedWork W1974781192 @default.
• W3087975767 hasRelatedWork W2124032293 @default.
• W3087975767 hasRelatedWork W2157069028 @default.
• W3087975767 hasRelatedWork W2158969140 @default.

• next