FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089379022> ?p ?o ?g. }

• W3089379022 endingPage "e1008209" @default.
• W3089379022 startingPage "e1008209" @default.
• W3089379022 abstract "Uncovering the underlying biophysical principles of emergent collective computational abilities, such as working memory, in neural circuits is one of the most essential concerns in modern neuroscience. Working memory system is often desired to be robust against noises. Such systems can be highly flexible for adapting environmental demands. How neural circuits reconfigure themselves according to the cognitive task requirement remains unclear. Previous studies explored the robustness and the flexibility in working memory by tracing individual dynamical trajectories in a limited time scale, where the accuracy of the results depends on the volume of the collected statistical data. Inspired by thermodynamics and statistical mechanics in physical systems, we developed a non-equilibrium landscape and flux framework for studying the neural network dynamics. Applying this approach to a biophysically based working memory model, we investigated how changes in the recurrent excitation mediated by slow NMDA receptors within a selective population and mutual inhibition mediated by GABAergic interneurons between populations affect the robustness against noises. This is realized through quantifying the underlying non-equilibrium potential landscape topography and the kinetics of state switching. We found that an optimal compromise for a working memory circuit between the robustness and the flexibility can be achieved through the emergence of an intermediate state between the working memory states. An optimal combination of both increased self-excitation and inhibition can enhance the flexibility to external signals without significantly reducing the robustness to the random fluctuations. Furthermore, we found that the enhanced performance in working memory is supported by larger energy consumption. Our approach can facilitate the design of new network structure for cognitive functions with the optimal balance between performance and cost. Our work also provides a new paradigm for exploring the underlying mechanisms of many cognitive functions based on non-equilibrium physics." @default.
• W3089379022 created "2020-10-08" @default.
• W3089379022 creator A5018244700 @default.
• W3089379022 creator A5044592466 @default.
• W3089379022 date "2020-10-02" @default.
• W3089379022 modified "2023-10-13" @default.
• W3089379022 title "Non-equilibrium landscape and flux reveal the stability-flexibility-energy tradeoff in working memory" @default.
• W3089379022 cites W1535321247 @default.
• W3089379022 cites W1603307924 @default.
• W3089379022 cites W1604195904 @default.
• W3089379022 cites W1916389823 @default.
• W3089379022 cites W1934970405 @default.
• W3089379022 cites W1963789865 @default.
• W3089379022 cites W1966841546 @default.
• W3089379022 cites W1970283086 @default.
• W3089379022 cites W1970779075 @default.
• W3089379022 cites W1974408180 @default.
• W3089379022 cites W1983388907 @default.
• W3089379022 cites W1992230893 @default.
• W3089379022 cites W2003405691 @default.
• W3089379022 cites W2010526455 @default.
• W3089379022 cites W2016354087 @default.
• W3089379022 cites W2017836845 @default.
• W3089379022 cites W2023237396 @default.
• W3089379022 cites W2025544758 @default.
• W3089379022 cites W2033237792 @default.
• W3089379022 cites W2048759415 @default.
• W3089379022 cites W2054181242 @default.
• W3089379022 cites W2062936056 @default.
• W3089379022 cites W2067029687 @default.
• W3089379022 cites W2070900790 @default.
• W3089379022 cites W2073696559 @default.
• W3089379022 cites W2076860310 @default.
• W3089379022 cites W2077999459 @default.
• W3089379022 cites W2081392261 @default.
• W3089379022 cites W2092853732 @default.
• W3089379022 cites W2107988867 @default.
• W3089379022 cites W2113345172 @default.
• W3089379022 cites W2122066429 @default.
• W3089379022 cites W2123880844 @default.
• W3089379022 cites W2127186958 @default.
• W3089379022 cites W2128084896 @default.
• W3089379022 cites W2133804059 @default.
• W3089379022 cites W2137700545 @default.
• W3089379022 cites W2138704896 @default.
• W3089379022 cites W2144095870 @default.
• W3089379022 cites W2151137320 @default.
• W3089379022 cites W2157518752 @default.
• W3089379022 cites W2159006998 @default.
• W3089379022 cites W2161983882 @default.
• W3089379022 cites W2167809052 @default.
• W3089379022 cites W2169519447 @default.
• W3089379022 cites W2172294131 @default.
• W3089379022 cites W2275929617 @default.
• W3089379022 cites W2594475619 @default.
• W3089379022 cites W4253613142 @default.
• W3089379022 cites W585702508 @default.
• W3089379022 doi "https://doi.org/10.1371/journal.pcbi.1008209" @default.
• W3089379022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7531819" @default.
• W3089379022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33006962" @default.
• W3089379022 hasPublicationYear "2020" @default.
• W3089379022 type Work @default.
• W3089379022 sameAs 3089379022 @default.
• W3089379022 citedByCount "8" @default.
• W3089379022 countsByYear W30893790222021 @default.
• W3089379022 countsByYear W30893790222022 @default.
• W3089379022 countsByYear W30893790222023 @default.
• W3089379022 crossrefType "journal-article" @default.
• W3089379022 hasAuthorship W3089379022A5018244700 @default.
• W3089379022 hasAuthorship W3089379022A5044592466 @default.
• W3089379022 hasBestOaLocation W30893790221 @default.
• W3089379022 hasConcept C104317684 @default.
• W3089379022 hasConcept C144024400 @default.
• W3089379022 hasConcept C149923435 @default.
• W3089379022 hasConcept C154945302 @default.
• W3089379022 hasConcept C169760540 @default.
• W3089379022 hasConcept C169900460 @default.
• W3089379022 hasConcept C186060115 @default.
• W3089379022 hasConcept C21963081 @default.
• W3089379022 hasConcept C2908647359 @default.
• W3089379022 hasConcept C41008148 @default.
• W3089379022 hasConcept C55493867 @default.
• W3089379022 hasConcept C63479239 @default.
• W3089379022 hasConcept C86803240 @default.
• W3089379022 hasConceptScore W3089379022C104317684 @default.
• W3089379022 hasConceptScore W3089379022C144024400 @default.
• W3089379022 hasConceptScore W3089379022C149923435 @default.
• W3089379022 hasConceptScore W3089379022C154945302 @default.
• W3089379022 hasConceptScore W3089379022C169760540 @default.
• W3089379022 hasConceptScore W3089379022C169900460 @default.
• W3089379022 hasConceptScore W3089379022C186060115 @default.
• W3089379022 hasConceptScore W3089379022C21963081 @default.
• W3089379022 hasConceptScore W3089379022C2908647359 @default.
• W3089379022 hasConceptScore W3089379022C41008148 @default.
• W3089379022 hasConceptScore W3089379022C55493867 @default.
• W3089379022 hasConceptScore W3089379022C63479239 @default.
• W3089379022 hasConceptScore W3089379022C86803240 @default.
• W3089379022 hasFunder F4320306076 @default.

• next