Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090409328> ?p ?o ?g. }
- W3090409328 endingPage "56" @default.
- W3090409328 startingPage "47" @default.
- W3090409328 abstract "Atypical teratoid rhabdoid tumor (ATRT) is a rare, often lethal brain tumor of childhood characterized by a complex epigenetic landscape amongst a simple genetic background. Recent molecular studies have defined key biologic events that contribute to tumorigenesis and molecular subtypes of ATRT.Seminal studies on ATRT are reviewed with an emphasis on molecular pathogenesis and its relevance to novel therapeutics.In this review, we summarize the key clinicopathologic and molecular features of ATRT, completed and ongoing clinical trials and outline the translational potential of novel insights into the molecular pathogenesis of this tumor.SMARCB1 loss is the key genetic event in ATRT pathogenesis that leads to widespread epigenetic dysregulation and loss of lineage-specific enhancers. Current work is defining subtype-specific treatments that target underlying molecular derangements that drive tumorigenesis." @default.
- W3090409328 created "2020-10-08" @default.
- W3090409328 creator A5003571131 @default.
- W3090409328 creator A5027180501 @default.
- W3090409328 creator A5047188733 @default.
- W3090409328 creator A5049032455 @default.
- W3090409328 creator A5053563254 @default.
- W3090409328 creator A5068257880 @default.
- W3090409328 date "2020-10-01" @default.
- W3090409328 modified "2023-10-16" @default.
- W3090409328 title "Atypical teratoid rhabdoid tumor: molecular insights and translation to novel therapeutics" @default.
- W3090409328 cites W1491201626 @default.
- W3090409328 cites W1585147201 @default.
- W3090409328 cites W1607620597 @default.
- W3090409328 cites W1920450187 @default.
- W3090409328 cites W1936404062 @default.
- W3090409328 cites W1966639599 @default.
- W3090409328 cites W1968608605 @default.
- W3090409328 cites W1976153898 @default.
- W3090409328 cites W1979321534 @default.
- W3090409328 cites W1991138928 @default.
- W3090409328 cites W1995056695 @default.
- W3090409328 cites W2004415585 @default.
- W3090409328 cites W2008769862 @default.
- W3090409328 cites W2020507784 @default.
- W3090409328 cites W2031063050 @default.
- W3090409328 cites W2032153769 @default.
- W3090409328 cites W2036468688 @default.
- W3090409328 cites W2042962536 @default.
- W3090409328 cites W2046378906 @default.
- W3090409328 cites W2055279984 @default.
- W3090409328 cites W2058823951 @default.
- W3090409328 cites W2061684407 @default.
- W3090409328 cites W2063851753 @default.
- W3090409328 cites W2071710018 @default.
- W3090409328 cites W2074270331 @default.
- W3090409328 cites W2081534093 @default.
- W3090409328 cites W2098118986 @default.
- W3090409328 cites W2099577209 @default.
- W3090409328 cites W2106578635 @default.
- W3090409328 cites W2117180730 @default.
- W3090409328 cites W2117482566 @default.
- W3090409328 cites W2119079421 @default.
- W3090409328 cites W2122370073 @default.
- W3090409328 cites W2132244178 @default.
- W3090409328 cites W2132310381 @default.
- W3090409328 cites W2139571929 @default.
- W3090409328 cites W2144143639 @default.
- W3090409328 cites W2157517980 @default.
- W3090409328 cites W2165853153 @default.
- W3090409328 cites W2167764385 @default.
- W3090409328 cites W2180907561 @default.
- W3090409328 cites W2235579757 @default.
- W3090409328 cites W2286341552 @default.
- W3090409328 cites W2337531543 @default.
- W3090409328 cites W2366536035 @default.
- W3090409328 cites W2396562105 @default.
- W3090409328 cites W2563878885 @default.
- W3090409328 cites W2564765645 @default.
- W3090409328 cites W2574453123 @default.
- W3090409328 cites W2591968025 @default.
- W3090409328 cites W2605858714 @default.
- W3090409328 cites W2760462427 @default.
- W3090409328 cites W2778602623 @default.
- W3090409328 cites W2883854821 @default.
- W3090409328 cites W2907733233 @default.
- W3090409328 cites W2967498829 @default.
- W3090409328 cites W2971104097 @default.
- W3090409328 cites W2978102442 @default.
- W3090409328 cites W2984765598 @default.
- W3090409328 cites W2986345436 @default.
- W3090409328 cites W2997655299 @default.
- W3090409328 cites W2998197281 @default.
- W3090409328 cites W3008366344 @default.
- W3090409328 cites W3010839856 @default.
- W3090409328 cites W3017825580 @default.
- W3090409328 cites W4360760134 @default.
- W3090409328 doi "https://doi.org/10.1007/s11060-020-03639-w" @default.
- W3090409328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8230985" @default.
- W3090409328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33021733" @default.
- W3090409328 hasPublicationYear "2020" @default.
- W3090409328 type Work @default.
- W3090409328 sameAs 3090409328 @default.
- W3090409328 citedByCount "21" @default.
- W3090409328 countsByYear W30904093282021 @default.
- W3090409328 countsByYear W30904093282022 @default.
- W3090409328 countsByYear W30904093282023 @default.
- W3090409328 crossrefType "journal-article" @default.
- W3090409328 hasAuthorship W3090409328A5003571131 @default.
- W3090409328 hasAuthorship W3090409328A5027180501 @default.
- W3090409328 hasAuthorship W3090409328A5047188733 @default.
- W3090409328 hasAuthorship W3090409328A5049032455 @default.
- W3090409328 hasAuthorship W3090409328A5053563254 @default.
- W3090409328 hasAuthorship W3090409328A5068257880 @default.
- W3090409328 hasBestOaLocation W30904093282 @default.
- W3090409328 hasConcept C104317684 @default.
- W3090409328 hasConcept C105580179 @default.
- W3090409328 hasConcept C121608353 @default.