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• W3092183847 abstract "Pharmacophore-directed retrosynthesis applied to ophiobolin A led to bicyclic derivatives that were synthesized and display anticancer activity. Key features of the ultimate defensive synthetic strategy include a Michael addition/facially selective protonation sequence to set the critical C6 stereocenter and a ring-closing metathesis to form the cyclooctene. Cytotoxicity assays toward a breast cancer cell line (MDA-MB-231) confirm the anticipated importance of structural complexity for selectivity (vs MCF10A cells) while C3 variations modulate stability." @default.
• W3092183847 created "2020-10-15" @default.
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• W3092183847 date "2020-10-09" @default.
• W3092183847 modified "2023-10-16" @default.
• W3092183847 title "Pharmacophore-Directed Retrosynthesis Applied to Ophiobolin A: Simplified Bicyclic Derivatives Displaying Anticancer Activity" @default.
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• W3092183847 doi "https://doi.org/10.1021/acs.orglett.0c02938" @default.
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