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• W3104969189 abstract "A dense network of blood vessels distributes blood to different regions of the brain. To meet the temporarily and spatially varying energy demand resulting from changes in neuronal activity, the vasculature is able to locally up-regulate the blood supply. However, to which extent diameter changes of different vessel types contribute to the up-regulation, as well as the spatial and temporal characteristics of their changes, are currently unknown. Here, we present a new simulation method, which solves an inverse problem to calculate diameter changes of individual blood vessels needed to achieve predefined blood flow distributions in microvascular networks. This allows us to systematically compare the impact of different vessel types in various regulation scenarios. Moreover, the method offers the advantage that it handles the stochastic nature of blood flow originating from tracking the movement of individual red blood cells. Since the inverse problem is formulated for time-averaged pressures and flow rates, a deterministic approach for calculating the diameter changes is used, which allows us to apply the method for large realistic microvascular networks with high-dimensional parameter spaces. Our results obtained in both artificial and realistic microvascular networks reveal that diameter changes at the level of capillaries enable a very localized regulation of blood flow. In scenarios where only larger vessels, i.e. arterioles, are allowed to adapt, the flow increase cannot be confined to a specific activated region and flow changes spread into neighbouring regions. Furthermore, relatively small dilations and constrictions of all vessel types can lead to substantial changes of capillary blood flow distributions. This suggests that small scale regulation is necessary to obtain a localized increase in blood flow." @default.
• W3104969189 created "2020-11-23" @default.
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• W3104969189 date "2020-10-16" @default.
• W3104969189 modified "2023-10-17" @default.
• W3104969189 title "Predicting Vessel Diameter Changes to Up-Regulate Biphasic Blood Flow During Activation in Realistic Microvascular Networks" @default.
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• W3104969189 doi "https://doi.org/10.3389/fphys.2020.566303" @default.
• W3104969189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7596696" @default.
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• W3104969189 hasPublicationYear "2020" @default.
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