Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107215818> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3107215818 abstract "Infections due to the opportunistic fungus Candida have been on the rise the last decades, especially in immunocompromised individuals and in hospital settings. Unfortunately, the treatments available today are limited, especially because of their severe side effects in patients, increase of multi-drug resistance and the eukaryotic nature of Candida. Thrombin-derived C-terminal peptide 25 (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory action. To evaluate if the dual-action of TCP-25 could be further extended, it was tested against two yeast strains, i.e. Candida albicans and Candida parapsilosis. The antifungal activity was investigated with viable count assay, radial diffusion assay and Live/Dead staining. The anti-inflammatory activity of TCP-25 against zymosan-induced monocytes was investigated as well. Lastly, the structural relationship between TCP-25 and zymosan was investigated using Circular Dichroism (CD) spectroscopy and intrinsic fluorescence. The results showed that TCP-25 was antifungal and inhibited inflammation in a dose-dependent manner. The peptide adopted a different secondary structure in the presence of zymosan, indicating a binding. Altogether, the results indicate that the dual-action of TCP-25 extends from prokaryotic bacteria to eukaryotic Candida species. (Less)" @default.
- W3107215818 created "2020-12-07" @default.
- W3107215818 creator A5002749401 @default.
- W3107215818 date "2020-01-01" @default.
- W3107215818 modified "2023-09-27" @default.
- W3107215818 title "Effects of thrombin-derived C-terminal peptide on Candida" @default.
- W3107215818 hasPublicationYear "2020" @default.
- W3107215818 type Work @default.
- W3107215818 sameAs 3107215818 @default.
- W3107215818 citedByCount "0" @default.
- W3107215818 crossrefType "journal-article" @default.
- W3107215818 hasAuthorship W3107215818A5002749401 @default.
- W3107215818 hasConcept C145081991 @default.
- W3107215818 hasConcept C185592680 @default.
- W3107215818 hasConcept C202751555 @default.
- W3107215818 hasConcept C2778870864 @default.
- W3107215818 hasConcept C2779222958 @default.
- W3107215818 hasConcept C2779281246 @default.
- W3107215818 hasConcept C2779443200 @default.
- W3107215818 hasConcept C2780917455 @default.
- W3107215818 hasConcept C4937899 @default.
- W3107215818 hasConcept C540938839 @default.
- W3107215818 hasConcept C55493867 @default.
- W3107215818 hasConcept C86803240 @default.
- W3107215818 hasConcept C89423630 @default.
- W3107215818 hasConceptScore W3107215818C145081991 @default.
- W3107215818 hasConceptScore W3107215818C185592680 @default.
- W3107215818 hasConceptScore W3107215818C202751555 @default.
- W3107215818 hasConceptScore W3107215818C2778870864 @default.
- W3107215818 hasConceptScore W3107215818C2779222958 @default.
- W3107215818 hasConceptScore W3107215818C2779281246 @default.
- W3107215818 hasConceptScore W3107215818C2779443200 @default.
- W3107215818 hasConceptScore W3107215818C2780917455 @default.
- W3107215818 hasConceptScore W3107215818C4937899 @default.
- W3107215818 hasConceptScore W3107215818C540938839 @default.
- W3107215818 hasConceptScore W3107215818C55493867 @default.
- W3107215818 hasConceptScore W3107215818C86803240 @default.
- W3107215818 hasConceptScore W3107215818C89423630 @default.
- W3107215818 hasLocation W31072158181 @default.
- W3107215818 hasOpenAccess W3107215818 @default.
- W3107215818 hasPrimaryLocation W31072158181 @default.
- W3107215818 hasRelatedWork W2011035831 @default.
- W3107215818 hasRelatedWork W2075831247 @default.
- W3107215818 hasRelatedWork W2116729426 @default.
- W3107215818 hasRelatedWork W2121172942 @default.
- W3107215818 hasRelatedWork W237973401 @default.
- W3107215818 hasRelatedWork W2423125834 @default.
- W3107215818 hasRelatedWork W2529512895 @default.
- W3107215818 hasRelatedWork W2783801552 @default.
- W3107215818 hasRelatedWork W2890333191 @default.
- W3107215818 hasRelatedWork W2907178631 @default.
- W3107215818 hasRelatedWork W3001758718 @default.
- W3107215818 hasRelatedWork W3007109396 @default.
- W3107215818 hasRelatedWork W3015389036 @default.
- W3107215818 hasRelatedWork W3172955221 @default.
- W3107215818 hasRelatedWork W3187792146 @default.
- W3107215818 hasRelatedWork W3195680054 @default.
- W3107215818 hasRelatedWork W3204355084 @default.
- W3107215818 hasRelatedWork W3211638474 @default.
- W3107215818 hasRelatedWork W3211835370 @default.
- W3107215818 hasRelatedWork W2039576290 @default.
- W3107215818 isParatext "false" @default.
- W3107215818 isRetracted "false" @default.
- W3107215818 magId "3107215818" @default.
- W3107215818 workType "article" @default.