FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118018916> ?p ?o ?g. }

• W3118018916 endingPage "1381" @default.
• W3118018916 startingPage "1371" @default.
• W3118018916 abstract "This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured by an enzyme-linked immunosorbent assay, and the pathological changes of colon tissue was examined by hematoxylin–eosin staining. Serum metabolomics and lipidomics analysis based on ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were applied to decipher the metabolic profile changes. Multivariate analysis was applied to differentiate the metabolites of controls, models, and mesalazine-treated mice. By the receiver operating characteristic (ROC) analysis, 40 differential metabolites with an area under curve (AUC) >0.80 were screened out between control and model groups. Among them, four potential biomarkers (palmitoyl glucuronide, isobutyrylglycine, PC (20:3 (5Z, 8Z, 11Z)/15:0) and L-arginine) had a signficantly reversed level of peak areas in the mesalazine group, and three of them were closely correlated with mesalazine efficacy by linear regression analysis. Furthermore, metabolic pathway analysis revealed several dysregulated pathways in colitis mice, including glycerophospholipid metabolism, pyrimidine metabolism, linoleic acid metabolism, arginine biosynthesis, etc. This study indicates that serum metabolomics is a useful approach that can noninvasively evaluate the therapeutic effect and provide unique insights into the underlying mechanism of mesalazine." @default.
• W3118018916 created "2021-01-05" @default.
• W3118018916 creator A5008681979 @default.
• W3118018916 creator A5023034801 @default.
• W3118018916 creator A5043273438 @default.
• W3118018916 creator A5050501022 @default.
• W3118018916 creator A5050680415 @default.
• W3118018916 creator A5056155405 @default.
• W3118018916 creator A5060422237 @default.
• W3118018916 creator A5060882671 @default.
• W3118018916 creator A5071284490 @default.
• W3118018916 date "2020-12-23" @default.
• W3118018916 modified "2023-09-30" @default.
• W3118018916 title "Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model" @default.
• W3118018916 cites W1493053781 @default.
• W3118018916 cites W1596258860 @default.
• W3118018916 cites W1855226200 @default.
• W3118018916 cites W1972100892 @default.
• W3118018916 cites W1990731021 @default.
• W3118018916 cites W2005573122 @default.
• W3118018916 cites W2018447001 @default.
• W3118018916 cites W2032304822 @default.
• W3118018916 cites W2036256897 @default.
• W3118018916 cites W2040561269 @default.
• W3118018916 cites W2043928338 @default.
• W3118018916 cites W2051103024 @default.
• W3118018916 cites W2051814417 @default.
• W3118018916 cites W2055461186 @default.
• W3118018916 cites W2074558856 @default.
• W3118018916 cites W2083923706 @default.
• W3118018916 cites W2085325808 @default.
• W3118018916 cites W2094464340 @default.
• W3118018916 cites W2094836162 @default.
• W3118018916 cites W2097042204 @default.
• W3118018916 cites W2110758916 @default.
• W3118018916 cites W2124063849 @default.
• W3118018916 cites W2133328370 @default.
• W3118018916 cites W2145135012 @default.
• W3118018916 cites W2346176715 @default.
• W3118018916 cites W2510387023 @default.
• W3118018916 cites W2566379979 @default.
• W3118018916 cites W2611686520 @default.
• W3118018916 cites W2762783366 @default.
• W3118018916 cites W2790141134 @default.
• W3118018916 cites W2800354113 @default.
• W3118018916 cites W2913787177 @default.
• W3118018916 cites W2916392843 @default.
• W3118018916 cites W2981653342 @default.
• W3118018916 cites W2996369424 @default.
• W3118018916 cites W3010421046 @default.
• W3118018916 cites W4252157436 @default.
• W3118018916 cites W4295333203 @default.
• W3118018916 doi "https://doi.org/10.1021/acs.jproteome.0c00757" @default.
• W3118018916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33356298" @default.
• W3118018916 hasPublicationYear "2020" @default.
• W3118018916 type Work @default.
• W3118018916 sameAs 3118018916 @default.
• W3118018916 citedByCount "17" @default.
• W3118018916 countsByYear W31180189162021 @default.
• W3118018916 countsByYear W31180189162022 @default.
• W3118018916 countsByYear W31180189162023 @default.
• W3118018916 crossrefType "journal-article" @default.
• W3118018916 hasAuthorship W3118018916A5008681979 @default.
• W3118018916 hasAuthorship W3118018916A5023034801 @default.
• W3118018916 hasAuthorship W3118018916A5043273438 @default.
• W3118018916 hasAuthorship W3118018916A5050501022 @default.
• W3118018916 hasAuthorship W3118018916A5050680415 @default.
• W3118018916 hasAuthorship W3118018916A5056155405 @default.
• W3118018916 hasAuthorship W3118018916A5060422237 @default.
• W3118018916 hasAuthorship W3118018916A5060882671 @default.
• W3118018916 hasAuthorship W3118018916A5071284490 @default.
• W3118018916 hasConcept C126322002 @default.
• W3118018916 hasConcept C135870905 @default.
• W3118018916 hasConcept C185592680 @default.
• W3118018916 hasConcept C192989942 @default.
• W3118018916 hasConcept C21565614 @default.
• W3118018916 hasConcept C2777477808 @default.
• W3118018916 hasConcept C2779134260 @default.
• W3118018916 hasConcept C2779174533 @default.
• W3118018916 hasConcept C2780479503 @default.
• W3118018916 hasConcept C43617362 @default.
• W3118018916 hasConcept C55493867 @default.
• W3118018916 hasConcept C58017582 @default.
• W3118018916 hasConcept C62231903 @default.
• W3118018916 hasConcept C71924100 @default.
• W3118018916 hasConcept C76318530 @default.
• W3118018916 hasConcept C98274493 @default.
• W3118018916 hasConceptScore W3118018916C126322002 @default.
• W3118018916 hasConceptScore W3118018916C135870905 @default.
• W3118018916 hasConceptScore W3118018916C185592680 @default.
• W3118018916 hasConceptScore W3118018916C192989942 @default.
• W3118018916 hasConceptScore W3118018916C21565614 @default.
• W3118018916 hasConceptScore W3118018916C2777477808 @default.
• W3118018916 hasConceptScore W3118018916C2779134260 @default.
• W3118018916 hasConceptScore W3118018916C2779174533 @default.
• W3118018916 hasConceptScore W3118018916C2780479503 @default.
• W3118018916 hasConceptScore W3118018916C43617362 @default.
• W3118018916 hasConceptScore W3118018916C55493867 @default.

• next