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- W3120772492 abstract "Sacubitril/valsartan (Entresto™; LCZ696) is the first angiotensin receptor-neprilysin inhibitor (ARNI) drug approved by the US and EU for heart failure (HF) and especially recommended for hypertensive HF (HHF). Sacubitril inhibits the enzyme neprilysin (NEP) which produces both beneficial and adverse effects in the human body. While LCZ696 causes beneficial cardiovascular effects, it may induce memory and cognitive dysfunction, or even exacerbate Alzheimer's disease (AD). This article reviewed data reported by experimental and clinical studies that examined NEP inhibitors and their dementia-related side effects. Based on the literature, LCZ696 increases the risk of memory and cognitive dysfunctions, and clinical trials failed to show compelling evidence for LCZ696 safety for the brain. Together, it was concluded that more experimental and clinical studies with particular focus on LCZ696 side effects on β-amyloid (Aβ) degradation are needed to assess LCZ696 safety for the cognitive function, especially in case of long-term administration." @default.
- W3120772492 created "2021-01-18" @default.
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- W3120772492 date "2021-03-01" @default.
- W3120772492 modified "2023-10-01" @default.
- W3120772492 title "Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!" @default.
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- W3120772492 doi "https://doi.org/10.1016/j.ejphar.2021.173851" @default.
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