Matches in SemOpenAlex for { <https://semopenalex.org/work/W3126509074> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3126509074 abstract "CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about their interplay and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we find that immunodominance is established in tumors, wherein CD8 T cell expansion is predominantly driven by the antigen that most stably binds MHC. T cells responding to subdominant antigens are enriched for a TCF1+ progenitor phenotype that has been correlated with response to immune checkpoint blockade (ICB) therapy. However, the subdominant T cell response does not preferentially benefit from ICB due to a dysfunctional subset of TCF1+ progenitor cells marked by CCR6 and Tc17 differentiation. Analysis of human samples and sequencing datasets indicates CCR6+ TCF1+ cells exist across human cancers and correlate with poor ICB response. Vaccination eliminates CCR6+ TCF1+ cells and dramatically expands the subdominant response, highlighting a strategy to optimally engage concurrent neoantigen responses against tumors." @default.
- W3126509074 created "2021-02-15" @default.
- W3126509074 creator A5001281792 @default.
- W3126509074 creator A5004067604 @default.
- W3126509074 creator A5004108376 @default.
- W3126509074 creator A5009218889 @default.
- W3126509074 creator A5010234110 @default.
- W3126509074 creator A5010621663 @default.
- W3126509074 creator A5016945493 @default.
- W3126509074 creator A5027901644 @default.
- W3126509074 creator A5038358764 @default.
- W3126509074 creator A5044262806 @default.
- W3126509074 creator A5047708165 @default.
- W3126509074 creator A5054613619 @default.
- W3126509074 creator A5055074462 @default.
- W3126509074 creator A5058982168 @default.
- W3126509074 creator A5066703834 @default.
- W3126509074 creator A5066803257 @default.
- W3126509074 creator A5071936673 @default.
- W3126509074 creator A5074071508 @default.
- W3126509074 creator A5081469068 @default.
- W3126509074 creator A5081760647 @default.
- W3126509074 date "2021-01-01" @default.
- W3126509074 modified "2023-09-25" @default.
- W3126509074 title "Antigen Dominance Hierarchies Shape TCF1+ Progenitor CD8 T Cell Phenotypes in Tumors" @default.
- W3126509074 doi "https://doi.org/10.2139/ssrn.3770111" @default.
- W3126509074 hasPublicationYear "2021" @default.
- W3126509074 type Work @default.
- W3126509074 sameAs 3126509074 @default.
- W3126509074 citedByCount "1" @default.
- W3126509074 countsByYear W31265090742021 @default.
- W3126509074 crossrefType "journal-article" @default.
- W3126509074 hasAuthorship W3126509074A5001281792 @default.
- W3126509074 hasAuthorship W3126509074A5004067604 @default.
- W3126509074 hasAuthorship W3126509074A5004108376 @default.
- W3126509074 hasAuthorship W3126509074A5009218889 @default.
- W3126509074 hasAuthorship W3126509074A5010234110 @default.
- W3126509074 hasAuthorship W3126509074A5010621663 @default.
- W3126509074 hasAuthorship W3126509074A5016945493 @default.
- W3126509074 hasAuthorship W3126509074A5027901644 @default.
- W3126509074 hasAuthorship W3126509074A5038358764 @default.
- W3126509074 hasAuthorship W3126509074A5044262806 @default.
- W3126509074 hasAuthorship W3126509074A5047708165 @default.
- W3126509074 hasAuthorship W3126509074A5054613619 @default.
- W3126509074 hasAuthorship W3126509074A5055074462 @default.
- W3126509074 hasAuthorship W3126509074A5058982168 @default.
- W3126509074 hasAuthorship W3126509074A5066703834 @default.
- W3126509074 hasAuthorship W3126509074A5066803257 @default.
- W3126509074 hasAuthorship W3126509074A5071936673 @default.
- W3126509074 hasAuthorship W3126509074A5074071508 @default.
- W3126509074 hasAuthorship W3126509074A5081469068 @default.
- W3126509074 hasAuthorship W3126509074A5081760647 @default.
- W3126509074 hasBestOaLocation W31265090742 @default.
- W3126509074 hasConcept C104317684 @default.
- W3126509074 hasConcept C127716648 @default.
- W3126509074 hasConcept C147483822 @default.
- W3126509074 hasConcept C151913843 @default.
- W3126509074 hasConcept C154317977 @default.
- W3126509074 hasConcept C15729860 @default.
- W3126509074 hasConcept C167672396 @default.
- W3126509074 hasConcept C201750760 @default.
- W3126509074 hasConcept C202751555 @default.
- W3126509074 hasConcept C28328180 @default.
- W3126509074 hasConcept C54355233 @default.
- W3126509074 hasConcept C86803240 @default.
- W3126509074 hasConceptScore W3126509074C104317684 @default.
- W3126509074 hasConceptScore W3126509074C127716648 @default.
- W3126509074 hasConceptScore W3126509074C147483822 @default.
- W3126509074 hasConceptScore W3126509074C151913843 @default.
- W3126509074 hasConceptScore W3126509074C154317977 @default.
- W3126509074 hasConceptScore W3126509074C15729860 @default.
- W3126509074 hasConceptScore W3126509074C167672396 @default.
- W3126509074 hasConceptScore W3126509074C201750760 @default.
- W3126509074 hasConceptScore W3126509074C202751555 @default.
- W3126509074 hasConceptScore W3126509074C28328180 @default.
- W3126509074 hasConceptScore W3126509074C54355233 @default.
- W3126509074 hasConceptScore W3126509074C86803240 @default.
- W3126509074 hasLocation W31265090741 @default.
- W3126509074 hasLocation W31265090742 @default.
- W3126509074 hasOpenAccess W3126509074 @default.
- W3126509074 hasPrimaryLocation W31265090741 @default.
- W3126509074 hasRelatedWork W1995362027 @default.
- W3126509074 hasRelatedWork W2051602476 @default.
- W3126509074 hasRelatedWork W2056324142 @default.
- W3126509074 hasRelatedWork W2080189381 @default.
- W3126509074 hasRelatedWork W2085085115 @default.
- W3126509074 hasRelatedWork W2107850890 @default.
- W3126509074 hasRelatedWork W2320448073 @default.
- W3126509074 hasRelatedWork W2397459822 @default.
- W3126509074 hasRelatedWork W2736550095 @default.
- W3126509074 hasRelatedWork W2801802577 @default.
- W3126509074 isParatext "false" @default.
- W3126509074 isRetracted "false" @default.
- W3126509074 magId "3126509074" @default.
- W3126509074 workType "article" @default.