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• W3135355220 endingPage "173981" @default.
• W3135355220 startingPage "173981" @default.
• W3135355220 abstract "Gestational diabetes mellitus (GDM) affects 5–10% of pregnancies and increases the risk of fetal and maternal adverse outcomes. Interestingly, the vascular response to AngII is decreased by pregnancy while the response is increased by diabetes. It remains unclear how GDM affects vascular tone and how angiotensin II receptors contribute to these changes. In this work, we sought to establish the vascular impact of a hypercaloric diet-induced GDM through changes in AT 1 and AT 2 receptor's expression. Female rats fed for 7 weeks with standard (SD) or hypercaloric (HD) diet were divided at week 4. Half of the rats of each group were mated to become pregnant and those fed with a HD developed GDM. AngII-induced vasoconstriction was measured in thoracic or abdominal aorta rings using a conventional isolated organ bath and AT 1 and AT 2 receptors were searched by immunohistochemistry. Experiments where conducted on the pregnant standard diet group (PSD) and the pregnant hypercaloric-gestational diabetes mellitus group (PHD-GDM). Vasoconstriction was reduced in the thoracic aorta (P < 0.05 vs PSD) but increased in the abdominal aorta of PHD-GDM rats (P < 0.05 vs PSD). Blockade of AT 2 receptors using PD123319 decreased vasoconstriction, particularly in the abdominal aorta of PHD-GDM animals (P < 0.05 vs PSD). PHD-GDM increased AT 1 receptors expression (P < 0.05 vs PSD). Also, PHD-GDM reverted physiologic hypoglycemia and hypotension of healthy pregnancy. Findings provide new insight into the hypercaloric diet induced damage on the vasculature during pregnancy." @default.
• W3135355220 created "2021-03-15" @default.
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• W3135355220 date "2021-05-01" @default.
• W3135355220 modified "2023-10-17" @default.
• W3135355220 title "Divergent impact of gestational diabetes mellitus between the thoracic and abdominal rat aorta: Influence of endothelium and angiotensin II receptors" @default.
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• W3135355220 doi "https://doi.org/10.1016/j.ejphar.2021.173981" @default.
• W3135355220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33689706" @default.
• W3135355220 hasPublicationYear "2021" @default.
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