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- W3135812463 abstract "Hydrogel formulations have drawbacks in delivering hydrophobic drugs which can affect its efficiency. Introducing amphiphilic system into hydrogel can overcome this limitation and increase hydrogel effectiveness as a drug cargo. In this study, four arms star-shaped block copolymers with polyethylene glycol (PEG) as hydrophilic block and polycaprolactone (PCL) as hydrophobic block were synthesized via a combination of ring-opening polymerization (ROP) and Steglich esterification. The structures were confirmed by 1H-NMR and FTIR analysis. The polydispersity index (PDI) indices from gas permeation chromatography (GPC) were 1.3 to 1.6 suggesting controlled polymerisation reaction occurred. Average molecular weight analysis, Mn based on 1H-NMR are close to the theoretical value. However, there is a slight difference of Mn between GPC and proton analysis due to the ability of GPC determining Mn for the star-shaped polymer. Both star-shaped polymers possesses high thermal stability (>350 °C) based on thermal decomposition study using TGA analysis. The presence of PEG had increased the hydrophilicity and solubility of the PCL in the hydrogel since an opaque homogeneous formulation form when using the amphiphilic star-shaped polymer. The pH (7.25 ± 0.03) and viscosity (9330 cP) of the formulation are set within the compatibility and suitable for human skin and topical application." @default.
- W3135812463 created "2021-03-15" @default.
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- W3135812463 date "2021-02-04" @default.
- W3135812463 modified "2023-10-18" @default.
- W3135812463 title "Synthesis of Four-arms Star-shaped PCL-b-PEG as a Potential Amphiphilic Hydrogel" @default.
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- W3135812463 doi "https://doi.org/10.24191/srj.v18i1.11515" @default.
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