Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136206766> ?p ?o ?g. }
- W3136206766 endingPage "13301" @default.
- W3136206766 startingPage "13294" @default.
- W3136206766 abstract "Abstract The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we investigate the protein‐catalyzed formation of antivirals by the 3C‐protease of enterovirus D68. The enzyme induces aldol condensations yielding inhibitors with antiviral activity in cells. Kinetic and thermodynamic analyses reveal that the bioactivity emerges from a dynamic reaction system including inhibitor formation, alkylation of the protein target by the inhibitors, and competitive addition of non‐protein nucleophiles to the inhibitors. The most active antivirals are slowly reversible inhibitors with elongated target residence times. The study reveals first examples for the chemical evolution of bio‐actives through protein‐catalyzed, non‐enzymatic C−C couplings. The discovered mechanism works under physiological conditions and might constitute a native process of drug development." @default.
- W3136206766 created "2021-03-29" @default.
- W3136206766 creator A5011890495 @default.
- W3136206766 creator A5015631077 @default.
- W3136206766 creator A5057670554 @default.
- W3136206766 creator A5060052640 @default.
- W3136206766 creator A5070857677 @default.
- W3136206766 creator A5073105044 @default.
- W3136206766 creator A5078777071 @default.
- W3136206766 creator A5078916398 @default.
- W3136206766 creator A5081353574 @default.
- W3136206766 creator A5089010495 @default.
- W3136206766 creator A5039960573 @default.
- W3136206766 date "2021-05-06" @default.
- W3136206766 modified "2023-10-10" @default.
- W3136206766 title "Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions" @default.
- W3136206766 cites W123206705 @default.
- W3136206766 cites W1526377515 @default.
- W3136206766 cites W1963801726 @default.
- W3136206766 cites W1988356128 @default.
- W3136206766 cites W1996751517 @default.
- W3136206766 cites W2006995201 @default.
- W3136206766 cites W2015995428 @default.
- W3136206766 cites W2040480490 @default.
- W3136206766 cites W2040680919 @default.
- W3136206766 cites W2054249920 @default.
- W3136206766 cites W2057280802 @default.
- W3136206766 cites W2062699336 @default.
- W3136206766 cites W2065633704 @default.
- W3136206766 cites W2086279550 @default.
- W3136206766 cites W2087765372 @default.
- W3136206766 cites W2102578622 @default.
- W3136206766 cites W2114626540 @default.
- W3136206766 cites W2127617013 @default.
- W3136206766 cites W2130346157 @default.
- W3136206766 cites W2137510121 @default.
- W3136206766 cites W2160052597 @default.
- W3136206766 cites W2168582787 @default.
- W3136206766 cites W219287239 @default.
- W3136206766 cites W2335203068 @default.
- W3136206766 cites W2386517417 @default.
- W3136206766 cites W2401030480 @default.
- W3136206766 cites W2526010451 @default.
- W3136206766 cites W2582322962 @default.
- W3136206766 cites W2588240447 @default.
- W3136206766 cites W2588900640 @default.
- W3136206766 cites W2615191080 @default.
- W3136206766 cites W2618283214 @default.
- W3136206766 cites W2737976898 @default.
- W3136206766 cites W2745346982 @default.
- W3136206766 cites W2910968223 @default.
- W3136206766 cites W2952757161 @default.
- W3136206766 cites W2959957910 @default.
- W3136206766 cites W2996361106 @default.
- W3136206766 cites W3026201818 @default.
- W3136206766 cites W3033652112 @default.
- W3136206766 cites W4235659722 @default.
- W3136206766 doi "https://doi.org/10.1002/anie.202102074" @default.
- W3136206766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8252737" @default.
- W3136206766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33749121" @default.
- W3136206766 hasPublicationYear "2021" @default.
- W3136206766 type Work @default.
- W3136206766 sameAs 3136206766 @default.
- W3136206766 citedByCount "5" @default.
- W3136206766 countsByYear W31362067662022 @default.
- W3136206766 countsByYear W31362067662023 @default.
- W3136206766 crossrefType "journal-article" @default.
- W3136206766 hasAuthorship W3136206766A5011890495 @default.
- W3136206766 hasAuthorship W3136206766A5015631077 @default.
- W3136206766 hasAuthorship W3136206766A5039960573 @default.
- W3136206766 hasAuthorship W3136206766A5057670554 @default.
- W3136206766 hasAuthorship W3136206766A5060052640 @default.
- W3136206766 hasAuthorship W3136206766A5070857677 @default.
- W3136206766 hasAuthorship W3136206766A5073105044 @default.
- W3136206766 hasAuthorship W3136206766A5078777071 @default.
- W3136206766 hasAuthorship W3136206766A5078916398 @default.
- W3136206766 hasAuthorship W3136206766A5081353574 @default.
- W3136206766 hasAuthorship W3136206766A5089010495 @default.
- W3136206766 hasBestOaLocation W31362067662 @default.
- W3136206766 hasConcept C161624437 @default.
- W3136206766 hasConcept C161790260 @default.
- W3136206766 hasConcept C168395250 @default.
- W3136206766 hasConcept C171852809 @default.
- W3136206766 hasConcept C178907741 @default.
- W3136206766 hasConcept C181199279 @default.
- W3136206766 hasConcept C185592680 @default.
- W3136206766 hasConcept C21951064 @default.
- W3136206766 hasConcept C2776714187 @default.
- W3136206766 hasConcept C55493867 @default.
- W3136206766 hasConcept C61156836 @default.
- W3136206766 hasConcept C74187038 @default.
- W3136206766 hasConceptScore W3136206766C161624437 @default.
- W3136206766 hasConceptScore W3136206766C161790260 @default.
- W3136206766 hasConceptScore W3136206766C168395250 @default.
- W3136206766 hasConceptScore W3136206766C171852809 @default.
- W3136206766 hasConceptScore W3136206766C178907741 @default.
- W3136206766 hasConceptScore W3136206766C181199279 @default.
- W3136206766 hasConceptScore W3136206766C185592680 @default.