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- W3137360139 abstract "SUMMARY Gα13 transduces signals from G protein-coupled receptors. Gα13 is pro-tumorigenic in epithelial cancer cell lines, which contrasts with its tumor-suppressive function in transgenic mouse models of lymphomas. Here we show that while loss of Gα13 in pancreatic cell lines decreases tumor growth in vivo , Gα13 loss in the Kras-driven (KC) mouse model of pancreatic tumor initiation does not affect tumor development or survival. Instead, Gα13 loss in the Kras/Tp53 (KPC) transgenic mouse model of advanced pancreatic cancer promotes well-differentiated tumors with increased tumor burden and reduced survival. Mechanistically, Gα13 loss in the KPC mouse model enhances E-cadherin-mediated cell-cell junctions and mTOR signaling. Importantly, human pancreatic cancers with low Gα13 expression exhibit increased E-cadherin protein expression and mTOR signaling. This work establishes a context-dependent role of Gα13 in pancreatic tumorigenesis, demonstrating a tumor-suppressive role in transgenic mouse models of advanced pancreatic cancer." @default.
- W3137360139 created "2021-03-29" @default.
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- W3137360139 date "2021-03-15" @default.
- W3137360139 modified "2023-09-26" @default.
- W3137360139 title "Gα13 loss promotes tumor progression in the KPC transgenic mouse model of advanced pancreatic cancer" @default.
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- W3137360139 doi "https://doi.org/10.1101/2021.03.15.435488" @default.
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