FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3138243082> ?p ?o ?g. }

• W3138243082 abstract "Background Necroptosis is a newly recognized form of programmed cell death with characteristics of both necrosis and apoptosis. The role of necroptosis in hepatic damage during sepsis is poorly understood. In this study, we investigated the occurrence of necroptosis in hepatic damage, and its contribution to hepatic damage in a piglet model of lipopolysaccharide (LPS)-induced sepsis. Methods Two animal experiments were conducted. In trial 1, piglets were challenged with LPS and sacrificed at different time points after LPS challenge. In trial 2, piglets were pretreated with necrostatin-1, a specific inhibitor of necroptosis, prior to LPS challenge. Alterations in the hepatic structure and function, pro-inflammatory cytokine expression, and the necroptosis signaling pathway were investigated. Typical ultrastructural characteristics of cell necrosis was observed in the liver of LPS-challenged piglets. Results Expressions of critical components of necroptosis including kinases (RIP1, RIP3, and MLKL), mitochondrial proteins (PGAM5 and DRP1), and an intracellular damage-associated molecular pattern (HMGB1) were increased in the liver in a time-dependent manner, followed by hepatic inflammation, morphological damage, and dysfunction as manifested by elevated hepatic expression of IL-1β, IL-6 and TNF-α as well as increased serum AST and AKP activities and the AST/ALT ratio. Pretreatment with necrostatin-1 significantly reduced the expression of RIP1, RIP3 and MLKL as well as PGAM5, DRP1 and HMGB1, which subsequently led to obvious attenuation of hepatic inflammation and damage. Conclusions Our study demonstrates that necroptosis occurs in the liver during sepsis and contributes to septic hepatic injury." @default.
• W3138243082 created "2021-03-29" @default.
• W3138243082 creator A5020095522 @default.
• W3138243082 creator A5040144517 @default.
• W3138243082 creator A5045011782 @default.
• W3138243082 creator A5046614213 @default.
• W3138243082 creator A5052654013 @default.
• W3138243082 creator A5058380236 @default.
• W3138243082 creator A5059625879 @default.
• W3138243082 creator A5071569702 @default.
• W3138243082 creator A5077829688 @default.
• W3138243082 creator A5083090268 @default.
• W3138243082 creator A5088601096 @default.
• W3138243082 date "2021-03-12" @default.
• W3138243082 modified "2023-10-01" @default.
• W3138243082 title "Necroptosis Underlies Hepatic Damage in a Piglet Model of Lipopolysaccharide-Induced Sepsis" @default.
• W3138243082 cites W1979032223 @default.
• W3138243082 cites W1993485143 @default.
• W3138243082 cites W2013606469 @default.
• W3138243082 cites W2093081515 @default.
• W3138243082 cites W2107277218 @default.
• W3138243082 cites W2142225943 @default.
• W3138243082 cites W2145577370 @default.
• W3138243082 cites W2158662692 @default.
• W3138243082 cites W2159190959 @default.
• W3138243082 cites W2164990391 @default.
• W3138243082 cites W2191498919 @default.
• W3138243082 cites W2361944635 @default.
• W3138243082 cites W2404648903 @default.
• W3138243082 cites W2473251429 @default.
• W3138243082 cites W2534411034 @default.
• W3138243082 cites W2596265142 @default.
• W3138243082 cites W2759187920 @default.
• W3138243082 cites W2771196527 @default.
• W3138243082 cites W2803146291 @default.
• W3138243082 cites W2804278924 @default.
• W3138243082 cites W2808829764 @default.
• W3138243082 cites W2890337997 @default.
• W3138243082 cites W2904356101 @default.
• W3138243082 cites W2938280340 @default.
• W3138243082 cites W2941155406 @default.
• W3138243082 cites W2943873997 @default.
• W3138243082 cites W2971079908 @default.
• W3138243082 cites W2991283014 @default.
• W3138243082 cites W3002188137 @default.
• W3138243082 doi "https://doi.org/10.3389/fimmu.2021.633830" @default.
• W3138243082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7994362" @default.
• W3138243082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33777021" @default.
• W3138243082 hasPublicationYear "2021" @default.
• W3138243082 type Work @default.
• W3138243082 sameAs 3138243082 @default.
• W3138243082 citedByCount "16" @default.
• W3138243082 countsByYear W31382430822021 @default.
• W3138243082 countsByYear W31382430822022 @default.
• W3138243082 countsByYear W31382430822023 @default.
• W3138243082 crossrefType "journal-article" @default.
• W3138243082 hasAuthorship W3138243082A5020095522 @default.
• W3138243082 hasAuthorship W3138243082A5040144517 @default.
• W3138243082 hasAuthorship W3138243082A5045011782 @default.
• W3138243082 hasAuthorship W3138243082A5046614213 @default.
• W3138243082 hasAuthorship W3138243082A5052654013 @default.
• W3138243082 hasAuthorship W3138243082A5058380236 @default.
• W3138243082 hasAuthorship W3138243082A5059625879 @default.
• W3138243082 hasAuthorship W3138243082A5071569702 @default.
• W3138243082 hasAuthorship W3138243082A5077829688 @default.
• W3138243082 hasAuthorship W3138243082A5083090268 @default.
• W3138243082 hasAuthorship W3138243082A5088601096 @default.
• W3138243082 hasBestOaLocation W31382430821 @default.
• W3138243082 hasConcept C142724271 @default.
• W3138243082 hasConcept C17991360 @default.
• W3138243082 hasConcept C190283241 @default.
• W3138243082 hasConcept C203014093 @default.
• W3138243082 hasConcept C2776914184 @default.
• W3138243082 hasConcept C2778384902 @default.
• W3138243082 hasConcept C2778754761 @default.
• W3138243082 hasConcept C2780545709 @default.
• W3138243082 hasConcept C31573885 @default.
• W3138243082 hasConcept C503630168 @default.
• W3138243082 hasConcept C55493867 @default.
• W3138243082 hasConcept C71924100 @default.
• W3138243082 hasConcept C86803240 @default.
• W3138243082 hasConcept C94030615 @default.
• W3138243082 hasConceptScore W3138243082C142724271 @default.
• W3138243082 hasConceptScore W3138243082C17991360 @default.
• W3138243082 hasConceptScore W3138243082C190283241 @default.
• W3138243082 hasConceptScore W3138243082C203014093 @default.
• W3138243082 hasConceptScore W3138243082C2776914184 @default.
• W3138243082 hasConceptScore W3138243082C2778384902 @default.
• W3138243082 hasConceptScore W3138243082C2778754761 @default.
• W3138243082 hasConceptScore W3138243082C2780545709 @default.
• W3138243082 hasConceptScore W3138243082C31573885 @default.
• W3138243082 hasConceptScore W3138243082C503630168 @default.
• W3138243082 hasConceptScore W3138243082C55493867 @default.
• W3138243082 hasConceptScore W3138243082C71924100 @default.
• W3138243082 hasConceptScore W3138243082C86803240 @default.
• W3138243082 hasConceptScore W3138243082C94030615 @default.
• W3138243082 hasLocation W31382430821 @default.
• W3138243082 hasLocation W31382430822 @default.
• W3138243082 hasLocation W31382430823 @default.
• W3138243082 hasOpenAccess W3138243082 @default.

• next