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- W3139137445 abstract "Liquid-liquid phase separation (LLPS) is currently of great interest in cell biology. LLPS is an example of what is called an emergent phenomenon -- an idea that comes from condensed-matter physics. Emergent phenomena have the characteristic feature of having a switch-like response. I show that the Hill equation of biochemistry can be used as a simple model of strongly cooperative, switch-like, behaviour. One result is that a switch-like response requires relatively few molecules, even ten gives a strongly switch-like response. Thus if a biological function enabled by LLPS relies on LLPS to provide a switch-like response to a stimulus, then condensates large enough to be visible in optical microscopy are not needed." @default.
- W3139137445 created "2021-03-29" @default.
- W3139137445 creator A5090873283 @default.
- W3139137445 date "2021-03-15" @default.
- W3139137445 modified "2023-09-27" @default.
- W3139137445 title "Liquid-liquid phase separation, biomolecular condensates, puncta, non-stoichiometric supramolecular assemblies, membraneless organelles, and bacterial chemotaxis are best understood as emergent phenomena with switch-like behaviour" @default.
- W3139137445 hasPublicationYear "2021" @default.
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