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- W3144878666 abstract "Objective To investigate the expression levels of interferon-inducible genes(IFITM1，IFITM2，IFITM3)in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus(SLE)，and the relations between these genes expression levels and disease activity are explored.Methods Reverse transcription polymerase chain reaction(RT-PCR)method was used to detect the expression levels of IFITM1，IFITM2，IFITM3 in 30 patients with SLE and 25 controls. The associations between the expression levels of IFITM1，IFITM2，IFITM3，complement C3，C4，anti-double stranded DNA antibody and SLEDAI scores in patients with SLE were analyzed.Results (1)The expression levels of IFITM1，IFITM2，IFITM3 in the SLE patients were significantly higher than those of the normal controls(P 0.05). There was no correlation between complement C3，C4，SLEDAI scores， anti-double stranded DNA antibody and the expression levels of IFITM2. (r 0.05).Conclusions The expression levels of IFITM1，IFITM2 and IFITM3 in patients with SLE are significantly higher than those of the normal controls. The expression levels of IFITM1，IFITM2 and IFITM3 showed positive correlations with each other. IFITM1 and IFITM3were negatively associated with complement C3，C4， and they are helpful in evaluating SLE disease activity and severity." @default.
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- W3144878666 date "2011-05-13" @default.
- W3144878666 modified "2023-09-27" @default.
- W3144878666 title "Expressions of interferon-inducible genes IFITM1，IFITM2 and IFITM3 in patients with systemic lupus erythematosus" @default.
- W3144878666 doi "https://doi.org/10.3877/368" @default.
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