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- W3164433005 abstract "Abstract Funding Acknowledgements Type of funding sources: None. Background Population based screening for atrial fibrillation (AF) has been suggested to reduce stroke. Photoplethysmography (PPG) deriving smartphone apps and single-lead electrocardiography (ECG) tools are attractive devices for screening due to their low cost, convenience, and accessibility. Automated algorithm analysis can serve as pre-screening or remote monitoring for AF, while confirmation on an ECG trace >30s is required to establish the diagnosis. This work directly compares the performance of proprietary algorithms on PPG vs single-lead ECG for the detection of AF. Purpose To evaluate and compare the diagnostic performance of a PPG-deriving smartphone app and a single-lead ECG-deriving handheld device for AF detection. Methods Patients were recruited from the cardiology ward. After obtaining written informed consent, demographic and medical information were collected. Patients were instructed to perform one measurement using a pulse-deriving smartphone app and one via a single-lead ECG handheld device. A 12-lead electrocardiogram (ECG) was collected and interpreted by a cardiologist as gold standard. Patients with atrial flutter were excluded, with additional exclusions for insufficient quality measurements and unsuccessful measurements resulting due to technical errors. Unclassified single-lead ECG measurements were handled as test-negative. Sensitivity, specificity and accuracy were calculated with respect to the reference diagnosis. McNemar’s analysis was performed to compare the sensitivity and specificity of the proprietary PPG and single-lead ECG AF detection algorithms. Results The median age in the study population (n = 300) was 70 years (interquartile range: 51-78), 56.3% were men, and the median CHA2DS2-VASc was 3 (interquartile range: 1-4) with an AF-prevalence of 32.3%. PPG signal and single‑lead ECG quality was sufficient in 272/300 (91.0%) and 278/298 (93.3%) participants, respectively. After excluding atrial flutter patients (n = 25) and insufficient quality measurements, the sensitivity and specificity were 97.6% (95% CI 93.8 to 99.3) and 94.1% (95% CI 86.8 to 98.1) for the PPG signal versus 95.7% (95% CI 91.4 to 98.3) and 91.1% (95% CI 83.2 to 96.1) for the single‑lead ECG signal, respectively. Results demonstrated a 96.4% (95% CI 93.2 to 98.3) accuracy for PPG and 94.1% (95% CI 90.4 to 96.6) for single-lead ECG. No significant differences in sensitivity (P = 0.453) or specificity (P = 0.219) between the proprietary PPG and single-lead ECG algorithms were found. Conclusion This study demonstrated equivalent diagnostic performance of PPG and single-lead ECG proprietary AF detection algorithms in smartphone apps." @default.
- W3164433005 created "2021-06-07" @default.
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- W3164433005 date "2021-05-01" @default.
- W3164433005 modified "2023-10-14" @default.
- W3164433005 title "Head-to-head comparison of proprietary PPG and single-lead ECG algorithms for atrial fibrillation detection" @default.
- W3164433005 doi "https://doi.org/10.1093/europace/euab116.524" @default.
- W3164433005 hasPublicationYear "2021" @default.
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