Matches in SemOpenAlex for { <https://semopenalex.org/work/W3178429581> ?p ?o ?g. }
- W3178429581 abstract "A secoiridoid glycoside called swertiamarin has been widely used as a herbal medicine for many decades. In particular, swertiamarin from the Enicostema axillare herb has been used as a multipurpose drug to treat innumerable health problems. As this medicine is consumed orally, its toxicity level should be determined. To examine the safety of this compound, toxicology work was done in zebrafish, and this is the first report to describe swertiamarin toxicity in zebrafish. Zebrafish embryos were used in this swertiamarin toxicity study, and morphological changes were observed. Further, the compound was also studied in adult zebrafish to determine the impact of the compound on the fish liver. Enzyme profiling with superoxide dismutase, glutathione peroxidase, catalase, reduced glutathione levels, glutathione S-transferase, lactate dehydrogenase, glutamic oxaloacetic transaminases, lipid peroxidation, Na+/K+-ATPase, and glutamic pyruvic transaminases) was evaluated (p ≤ 0.05). Results suggest that swertiamarin is a safe drug only at a low concentration (40 µM). This study also shows that even herbal medicinal compounds may be toxic to humans at higher dosages. Hence, irrespective of whether a drug is synthetic or natural, it needs to be tested for its toxicity before use in humans." @default.
- W3178429581 created "2021-07-19" @default.
- W3178429581 creator A5085176252 @default.
- W3178429581 creator A5085562594 @default.
- W3178429581 creator A5091442029 @default.
- W3178429581 date "2021-07-12" @default.
- W3178429581 modified "2023-10-17" @default.
- W3178429581 title "Developmental toxicity, antioxidant, and marker enzyme assessment of swertiamarin in zebrafish ( <i>Danio rerio</i> )" @default.
- W3178429581 cites W1410735928 @default.
- W3178429581 cites W1510015919 @default.
- W3178429581 cites W1581414347 @default.
- W3178429581 cites W1608086260 @default.
- W3178429581 cites W191793640 @default.
- W3178429581 cites W1963885414 @default.
- W3178429581 cites W1969712562 @default.
- W3178429581 cites W1972738934 @default.
- W3178429581 cites W1974022535 @default.
- W3178429581 cites W1975297761 @default.
- W3178429581 cites W1978858481 @default.
- W3178429581 cites W1981007299 @default.
- W3178429581 cites W1984773260 @default.
- W3178429581 cites W1989239048 @default.
- W3178429581 cites W1993926520 @default.
- W3178429581 cites W1999074746 @default.
- W3178429581 cites W2004367631 @default.
- W3178429581 cites W2006370393 @default.
- W3178429581 cites W2018800973 @default.
- W3178429581 cites W2022677638 @default.
- W3178429581 cites W2023601990 @default.
- W3178429581 cites W2031358524 @default.
- W3178429581 cites W2034448552 @default.
- W3178429581 cites W2039965406 @default.
- W3178429581 cites W2041795355 @default.
- W3178429581 cites W2051261987 @default.
- W3178429581 cites W2057511404 @default.
- W3178429581 cites W2058802122 @default.
- W3178429581 cites W2060194897 @default.
- W3178429581 cites W2062306007 @default.
- W3178429581 cites W2065375782 @default.
- W3178429581 cites W2070139425 @default.
- W3178429581 cites W2073404756 @default.
- W3178429581 cites W2086111284 @default.
- W3178429581 cites W2086521053 @default.
- W3178429581 cites W2088866343 @default.
- W3178429581 cites W2089286199 @default.
- W3178429581 cites W2102888522 @default.
- W3178429581 cites W2110358738 @default.
- W3178429581 cites W2115372161 @default.
- W3178429581 cites W2125349610 @default.
- W3178429581 cites W2128728801 @default.
- W3178429581 cites W2129232508 @default.
- W3178429581 cites W2133767949 @default.
- W3178429581 cites W2145711950 @default.
- W3178429581 cites W2146774140 @default.
- W3178429581 cites W2155054693 @default.
- W3178429581 cites W2166753099 @default.
- W3178429581 cites W2169900825 @default.
- W3178429581 cites W2263023695 @default.
- W3178429581 cites W2346171681 @default.
- W3178429581 cites W2511133664 @default.
- W3178429581 cites W2531687398 @default.
- W3178429581 cites W2583968998 @default.
- W3178429581 cites W2589058488 @default.
- W3178429581 cites W2594765619 @default.
- W3178429581 cites W2739832860 @default.
- W3178429581 cites W2784202279 @default.
- W3178429581 cites W96703952 @default.
- W3178429581 doi "https://doi.org/10.1002/jbt.22843" @default.
- W3178429581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34251064" @default.
- W3178429581 hasPublicationYear "2021" @default.
- W3178429581 type Work @default.
- W3178429581 sameAs 3178429581 @default.
- W3178429581 citedByCount "9" @default.
- W3178429581 countsByYear W31784295812022 @default.
- W3178429581 countsByYear W31784295812023 @default.
- W3178429581 crossrefType "journal-article" @default.
- W3178429581 hasAuthorship W3178429581A5085176252 @default.
- W3178429581 hasAuthorship W3178429581A5085562594 @default.
- W3178429581 hasAuthorship W3178429581A5091442029 @default.
- W3178429581 hasConcept C104317684 @default.
- W3178429581 hasConcept C116263406 @default.
- W3178429581 hasConcept C178790620 @default.
- W3178429581 hasConcept C181199279 @default.
- W3178429581 hasConcept C185592680 @default.
- W3178429581 hasConcept C2775838275 @default.
- W3178429581 hasConcept C2776878037 @default.
- W3178429581 hasConcept C2777318727 @default.
- W3178429581 hasConcept C2778004101 @default.
- W3178429581 hasConcept C2778760513 @default.
- W3178429581 hasConcept C2778979269 @default.
- W3178429581 hasConcept C2780829032 @default.
- W3178429581 hasConcept C29730261 @default.
- W3178429581 hasConcept C538909803 @default.
- W3178429581 hasConcept C55493867 @default.
- W3178429581 hasConcept C86803240 @default.
- W3178429581 hasConcept C98274493 @default.
- W3178429581 hasConceptScore W3178429581C104317684 @default.
- W3178429581 hasConceptScore W3178429581C116263406 @default.
- W3178429581 hasConceptScore W3178429581C178790620 @default.
- W3178429581 hasConceptScore W3178429581C181199279 @default.