FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196041712> ?p ?o ?g. }

• W3196041712 abstract "Abstract Blastocysts hatch from the zona pellucida (ZP) to enable implantation into the uterine endometrial epithelium, but little is known regarding the effect of hatching sites on pregnancy outcomes. Murine hatching embryos were categorized into five groups based on initial trophectoderm projection (TEP)/ZP position corresponding to the inner cell mass center. In blastocysts (3.5 dpc) post‐12 hours in vitro culture, TEP rates of A‐site (44.4%) and B‐site (38.6%) embryos were higher than those of C‐site (12.5%) and D‐site (3.1%) embryos, while the O‐site (1.4%) was the lowest ( P < .05). Post‐ET A‐site (55.6%) and B‐site (65.6%) birth rates were higher than those of C‐site embryos (21.3%) and controls ( P < .05). Furthermore, live birth rate of B‐site embryos remained higher than C‐site embryos (68.8% vs 31.3%; P < .05) when both were transferred into the same recipients. Different TEP site blastocysts exhibited different implantation competences: the implantation rate of C‐site embryos was lower than that of both A‐ and B‐site groups (67.7% vs 84.3% and 83.2%, respectively; P < .05) at 2 days post‐ET. C‐site embryos also had a distinctly higher ratio of developmental defects (47.5%) than A‐ and B‐site embryos (22.5% and 14.6%, respectively), with implantation failure mainly associated with poor birth rate, a finding corroborated by differential gene expression analysis such as LIF, LIFR, and S100a9. Surprisingly, acidified Tyrode's solution (AAH)‐treated B‐site blastocysts had a significantly increased birth rate (77.1%) than C‐site (55.3%) and controls (43.4%). Site specificity and differential gene expression during embryo hatching can be applied in ART screening. More importantly, assisted hatching by AAH is effective and feasible for improving pregnancy and term development, particularly at the B‐site, for humans and in animal husbandry." @default.
• W3196041712 created "2021-08-30" @default.
• W3196041712 creator A5013490723 @default.
• W3196041712 creator A5024693956 @default.
• W3196041712 creator A5052768034 @default.
• W3196041712 creator A5055629417 @default.
• W3196041712 creator A5062088989 @default.
• W3196041712 creator A5077972623 @default.
• W3196041712 creator A5082230544 @default.
• W3196041712 creator A5087700327 @default.
• W3196041712 date "2021-08-19" @default.
• W3196041712 modified "2023-10-14" @default.
• W3196041712 title "Site specificity of blastocyst hatching significantly influences pregnancy outcomes in mice" @default.
• W3196041712 cites W1771107213 @default.
• W3196041712 cites W1969068135 @default.
• W3196041712 cites W1970249138 @default.
• W3196041712 cites W1970357508 @default.
• W3196041712 cites W1977433933 @default.
• W3196041712 cites W1986570767 @default.
• W3196041712 cites W1987526091 @default.
• W3196041712 cites W1987971437 @default.
• W3196041712 cites W1989489844 @default.
• W3196041712 cites W1990498979 @default.
• W3196041712 cites W1995559307 @default.
• W3196041712 cites W2006494078 @default.
• W3196041712 cites W2010754935 @default.
• W3196041712 cites W2012768766 @default.
• W3196041712 cites W2061604516 @default.
• W3196041712 cites W2062403136 @default.
• W3196041712 cites W2062734024 @default.
• W3196041712 cites W2072539890 @default.
• W3196041712 cites W2090147511 @default.
• W3196041712 cites W2105142263 @default.
• W3196041712 cites W2131058385 @default.
• W3196041712 cites W2144759797 @default.
• W3196041712 cites W2153877443 @default.
• W3196041712 cites W2155556701 @default.
• W3196041712 cites W2208418059 @default.
• W3196041712 cites W2219332341 @default.
• W3196041712 cites W2232816331 @default.
• W3196041712 cites W2282603493 @default.
• W3196041712 cites W2314147353 @default.
• W3196041712 cites W2511262363 @default.
• W3196041712 cites W2610454042 @default.
• W3196041712 cites W2738232572 @default.
• W3196041712 cites W2752444812 @default.
• W3196041712 cites W2767784030 @default.
• W3196041712 cites W2774732615 @default.
• W3196041712 cites W2785261116 @default.
• W3196041712 cites W2809122805 @default.
• W3196041712 cites W2890183842 @default.
• W3196041712 cites W2890318234 @default.
• W3196041712 cites W2891382188 @default.
• W3196041712 cites W2909045536 @default.
• W3196041712 cites W2963000716 @default.
• W3196041712 cites W3000125014 @default.
• W3196041712 cites W3005775007 @default.
• W3196041712 doi "https://doi.org/10.1096/fj.202100653r" @default.
• W3196041712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34411354" @default.
• W3196041712 hasPublicationYear "2021" @default.
• W3196041712 type Work @default.
• W3196041712 sameAs 3196041712 @default.
• W3196041712 citedByCount "2" @default.
• W3196041712 countsByYear W31960417122023 @default.
• W3196041712 crossrefType "journal-article" @default.
• W3196041712 hasAuthorship W3196041712A5013490723 @default.
• W3196041712 hasAuthorship W3196041712A5024693956 @default.
• W3196041712 hasAuthorship W3196041712A5052768034 @default.
• W3196041712 hasAuthorship W3196041712A5055629417 @default.
• W3196041712 hasAuthorship W3196041712A5062088989 @default.
• W3196041712 hasAuthorship W3196041712A5077972623 @default.
• W3196041712 hasAuthorship W3196041712A5082230544 @default.
• W3196041712 hasAuthorship W3196041712A5087700327 @default.
• W3196041712 hasConcept C140793950 @default.
• W3196041712 hasConcept C159399396 @default.
• W3196041712 hasConcept C16685009 @default.
• W3196041712 hasConcept C196843134 @default.
• W3196041712 hasConcept C2776010925 @default.
• W3196041712 hasConcept C2776690073 @default.
• W3196041712 hasConcept C2777744765 @default.
• W3196041712 hasConcept C2778177303 @default.
• W3196041712 hasConcept C54355233 @default.
• W3196041712 hasConcept C71924100 @default.
• W3196041712 hasConcept C86803240 @default.
• W3196041712 hasConcept C87073359 @default.
• W3196041712 hasConceptScore W3196041712C140793950 @default.
• W3196041712 hasConceptScore W3196041712C159399396 @default.
• W3196041712 hasConceptScore W3196041712C16685009 @default.
• W3196041712 hasConceptScore W3196041712C196843134 @default.
• W3196041712 hasConceptScore W3196041712C2776010925 @default.
• W3196041712 hasConceptScore W3196041712C2776690073 @default.
• W3196041712 hasConceptScore W3196041712C2777744765 @default.
• W3196041712 hasConceptScore W3196041712C2778177303 @default.
• W3196041712 hasConceptScore W3196041712C54355233 @default.
• W3196041712 hasConceptScore W3196041712C71924100 @default.
• W3196041712 hasConceptScore W3196041712C86803240 @default.
• W3196041712 hasConceptScore W3196041712C87073359 @default.
• W3196041712 hasFunder F4320321001 @default.
• W3196041712 hasIssue "9" @default.
• W3196041712 hasLocation W31960417121 @default.

• next