FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198121570> ?p ?o ?g. }

• W3198121570 abstract "Abstract Background : Metastasis is the major cause of mortality in breast cancer; however, the molecular mechanisms remain elusive. In our previous study, we demonstrated that S100A7/RAGE mediates breast cancer growth and metastasis by recruitment of tumor-associated macrophages. However, the downstream S100A7-mediated inflammatory oncogenic signaling cascade that enhances breast tumor growth and metastasis by generating the immunosuppressive tumor microenvironment (iTME) has not been studied. In this present study, we aimed to investigate the S100A7 and cPLA2 cross-talk in enhancing tumor growth and metastasis through enhancing the iTME. Methods : Human breast cancer tissue and plasma samples were used to analyze the expression of S100A7, cPLA2, and PGE2 titer. S100A7-overexpressing or downregulated human metastatic breast cancer cells were used to evaluate the S100A7-mediated downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3(1)/Tag transgenic, and humanized patient-derived xenograft mouse models and cPLA2 inhibitor (AACOCF3) were used to investigate the role of S100A7/cPLA2/PGE2 signaling in tumor growth and metastasis. Additionally, CODEX, a highly advanced multiplexed imaging was employed to delineate the effect of S100A7/cPLA2 inhibition on the recruitment of various immune cells. Results : S100A7 and cPLA2 are highly expressed and positively correlated in malignant breast cancer patients. S100A7/RAGE upregulates cPLA2/PGE2 axis in aggressive breast cancer cells. Furthermore, S100A7 is positively correlated with PGE2 in breast cancer patients. Moreover, cPLA2 pharmacological inhibition suppressed S100A7-mediated tumor growth and metastasis in multiple pre-clinical models. Mechanistically, S100A7-mediated activation of cPLA2 enhances the recruitment of immunosuppressive myeloid cells by increasing PGE2 to fuel breast cancer growth and its secondary spread. We revealed that cPLA2 inhibitor mitigates S100A7-mediated breast tumorigenicity by suppressing the iTME. Furthermore, CODEX imaging data showed that cPLA2 inhibition increased the infiltration of CD4 + /CD8 + T cells in the TME. Analysis of metastatic breast cancer samples revealed a positive correlation between S100A7/cPLA2 with CD163 + tumor-associated M2-macrophages. Conclusions : Our study shows that cross-talk between S100A7 and cPLA2 plays an important role in enhancing breast tumor growth and metastasis by generating an immunosuppressive tumor microenvironment and reducing infiltration of T cells. Furthermore, S100A7 could be used as a novel non-invasive prognostic marker and cPLA2 inhibitors as promising drugs against S100A7-overexpressing metastatic breast cancer." @default.
• W3198121570 created "2021-09-13" @default.
• W3198121570 creator A5018977804 @default.
• W3198121570 creator A5022709344 @default.
• W3198121570 creator A5027261545 @default.
• W3198121570 creator A5028128038 @default.
• W3198121570 creator A5029762163 @default.
• W3198121570 creator A5030589427 @default.
• W3198121570 creator A5032857151 @default.
• W3198121570 creator A5034453574 @default.
• W3198121570 creator A5044563026 @default.
• W3198121570 creator A5057499054 @default.
• W3198121570 creator A5061137114 @default.
• W3198121570 creator A5067698508 @default.
• W3198121570 creator A5070076002 @default.
• W3198121570 creator A5082671116 @default.
• W3198121570 creator A5086584544 @default.
• W3198121570 creator A5090455449 @default.
• W3198121570 creator A5090814314 @default.
• W3198121570 date "2021-08-26" @default.
• W3198121570 modified "2023-09-26" @default.
• W3198121570 title "cPLA2 Blockade Attenuates S100A7-Mediated Breast Tumorigenicity by Inhibiting the Immunosuppressive Tumor Microenvironment" @default.
• W3198121570 doi "https://doi.org/10.21203/rs.3.rs-829313/v1" @default.
• W3198121570 hasPublicationYear "2021" @default.
• W3198121570 type Work @default.
• W3198121570 sameAs 3198121570 @default.
• W3198121570 citedByCount "0" @default.
• W3198121570 crossrefType "posted-content" @default.
• W3198121570 hasAuthorship W3198121570A5018977804 @default.
• W3198121570 hasAuthorship W3198121570A5022709344 @default.
• W3198121570 hasAuthorship W3198121570A5027261545 @default.
• W3198121570 hasAuthorship W3198121570A5028128038 @default.
• W3198121570 hasAuthorship W3198121570A5029762163 @default.
• W3198121570 hasAuthorship W3198121570A5030589427 @default.
• W3198121570 hasAuthorship W3198121570A5032857151 @default.
• W3198121570 hasAuthorship W3198121570A5034453574 @default.
• W3198121570 hasAuthorship W3198121570A5044563026 @default.
• W3198121570 hasAuthorship W3198121570A5057499054 @default.
• W3198121570 hasAuthorship W3198121570A5061137114 @default.
• W3198121570 hasAuthorship W3198121570A5067698508 @default.
• W3198121570 hasAuthorship W3198121570A5070076002 @default.
• W3198121570 hasAuthorship W3198121570A5082671116 @default.
• W3198121570 hasAuthorship W3198121570A5086584544 @default.
• W3198121570 hasAuthorship W3198121570A5090455449 @default.
• W3198121570 hasAuthorship W3198121570A5090814314 @default.
• W3198121570 hasBestOaLocation W31981215701 @default.
• W3198121570 hasConcept C121608353 @default.
• W3198121570 hasConcept C126322002 @default.
• W3198121570 hasConcept C143998085 @default.
• W3198121570 hasConcept C2776107976 @default.
• W3198121570 hasConcept C2779013556 @default.
• W3198121570 hasConcept C502942594 @default.
• W3198121570 hasConcept C530470458 @default.
• W3198121570 hasConcept C71924100 @default.
• W3198121570 hasConceptScore W3198121570C121608353 @default.
• W3198121570 hasConceptScore W3198121570C126322002 @default.
• W3198121570 hasConceptScore W3198121570C143998085 @default.
• W3198121570 hasConceptScore W3198121570C2776107976 @default.
• W3198121570 hasConceptScore W3198121570C2779013556 @default.
• W3198121570 hasConceptScore W3198121570C502942594 @default.
• W3198121570 hasConceptScore W3198121570C530470458 @default.
• W3198121570 hasConceptScore W3198121570C71924100 @default.
• W3198121570 hasLocation W31981215701 @default.
• W3198121570 hasLocation W31981215702 @default.
• W3198121570 hasOpenAccess W3198121570 @default.
• W3198121570 hasPrimaryLocation W31981215701 @default.
• W3198121570 hasRelatedWork W1499339123 @default.
• W3198121570 hasRelatedWork W2024594909 @default.
• W3198121570 hasRelatedWork W2789798659 @default.
• W3198121570 hasRelatedWork W2904294837 @default.
• W3198121570 hasRelatedWork W3033874287 @default.
• W3198121570 hasRelatedWork W3088410393 @default.
• W3198121570 hasRelatedWork W3160695097 @default.
• W3198121570 hasRelatedWork W3173207637 @default.
• W3198121570 hasRelatedWork W3183783449 @default.
• W3198121570 hasRelatedWork W377899687 @default.
• W3198121570 isParatext "false" @default.
• W3198121570 isRetracted "false" @default.
• W3198121570 magId "3198121570" @default.
• W3198121570 workType "article" @default.