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- W3199033192 abstract "Dendritic spines are critical components of neuronal synapses as they receive and transform synaptic inputs into a succession of calcium-regulated biochemical events. The spine apparatus (SA), an extension of smooth endoplasmic reticulum, regulates slow and fast calcium dynamics in spines. Calcium release events deplete SA calcium ion reservoir rapidly, yet the next cycle of signaling requires its replenishment. How spines achieve this replenishment without triggering calcium release remains unclear. Using computational modeling, calcium and STED superresolution imaging, we show that the SA replenishment involves the store-operated calcium entry pathway during spontaneous calcium transients. We identified two main conditions for SA replenishment without depletion: a small amplitude and a slow timescale for calcium influx, and a close proximity between SA and plasma membranes. Thereby, spine’s nanoscale organization separates SA replenishment from depletion. We further conclude that spine’s receptor organization also determines the calcium dynamics during the induction of long-term synaptic changes." @default.
- W3199033192 created "2021-09-27" @default.
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- W3199033192 date "2021-09-17" @default.
- W3199033192 modified "2023-10-17" @default.
- W3199033192 title "Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines" @default.
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- W3199033192 doi "https://doi.org/10.1126/sciadv.abh1376" @default.
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