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- W3200329255 endingPage "109663" @default.
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- W3200329255 abstract "The problem of excessive aluminum (Al) content in food is widespread. After Al enters the body, it can cause mineral metabolism imbalance and reactive oxygen species (ROS) overproduction, which ultimately leads to bone impairment. ROS is mainly produced in mitochondria and acts on mitochondria. Mitochondrial damage is closely related to mitophagy and apoptosis. In order to clarify whether ROS-mediated mitophagy and apoptosis are involved in Al-induced femoral impairment, forty-eight male C57BL/6 N mice were exposed to AlCl3 (179.3 mg/kg) and/or NAC (100 mg/kg) for 90 days. Our results showed that NAC inhibited the mitophagy and apoptosis, and alleviated growth inhibition, mineral metabolism imbalance, structural damage, decreased bone mineral density and decreased bone formation factor expressions in the femora of Al-treated mice. These results suggest that ROS-mediated mitophagy and apoptosis are involved in Al-induced femoral impairment in mice, exogenous ROS clearance is a potential strategy for the treatment of Al-induced bone impairment." @default.
- W3200329255 created "2021-09-27" @default.
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- W3200329255 date "2021-11-01" @default.
- W3200329255 modified "2023-10-04" @default.
- W3200329255 title "ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice" @default.
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- W3200329255 doi "https://doi.org/10.1016/j.cbi.2021.109663" @default.
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