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• W3200910429 abstract "Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown to improve male reproductive functions. Thus, irisin is a molecule of great interest in exploring the amelioration of metabolic syndrome or obesity-induced male infertility. In this review we aim to enumerate the most significant aspects of irisin actions and discuss its involvement in energy homeostasis and male reproduction. Though current and future research on irisin is very promiscuous, a number of clarifications are still needed to reveal its full potential as a significant medicinal target in several human diseases including male infertility." @default.
• W3200910429 created "2021-09-27" @default.
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• W3200910429 creator A5079643462 @default.
• W3200910429 date "2021-09-21" @default.
• W3200910429 modified "2023-10-12" @default.
• W3200910429 title "Irisin, Energy Homeostasis and Male Reproduction" @default.
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• W3200910429 doi "https://doi.org/10.3389/fphys.2021.746049" @default.
• W3200910429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8490744" @default.
• W3200910429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34621189" @default.
• W3200910429 hasPublicationYear "2021" @default.
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