Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202541877> ?p ?o ?g. }
- W3202541877 abstract "Ischaemic brain injury causes permanent neuronal loss, which often results in persistent severe neurological dysfunctions. Although generating new neurons in the injured brain would be an ideal approach to replenish the lost neurons for repairing the damage, the adult mammalian brain retains only limited neurogenic capability. Here, we show that direct conversion of microglia/macrophages into neurons in the brain has great potential as a therapeutic strategy for ischaemic brain injury. After transient middle cerebral artery occlusion in adult mice, microglia/macrophages converge at the lesion core of the striatum, where neuronal loss is prominent. Targeted expression of a neurogenic transcription factor, NeuroD1, in microglia/macrophages in the injured striatum enables their conversion into induced neuronal cells that functionally integrate into the existing neuronal circuits. Furthermore, NeuroD1-mediated induced neuronal cell generation significantly improves neurological function in the mouse stroke model, and ablation of these cells abolishes the gained functional recovery. Our findings thus demonstrate that neuronal conversion contributes directly to functional recovery after stroke and shed further light on the development of therapies for ischaemic brain injury by in situ neuronal conversion technology." @default.
- W3202541877 created "2021-10-11" @default.
- W3202541877 creator A5001524034 @default.
- W3202541877 creator A5011156831 @default.
- W3202541877 creator A5032557530 @default.
- W3202541877 creator A5057261755 @default.
- W3202541877 creator A5065624209 @default.
- W3202541877 creator A5066227014 @default.
- W3202541877 date "2021-09-27" @default.
- W3202541877 modified "2023-10-16" @default.
- W3202541877 title "Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke" @default.
- W3202541877 cites W1763750158 @default.
- W3202541877 cites W1771186062 @default.
- W3202541877 cites W1968310639 @default.
- W3202541877 cites W1987171954 @default.
- W3202541877 cites W1991086765 @default.
- W3202541877 cites W1999952543 @default.
- W3202541877 cites W2001419937 @default.
- W3202541877 cites W2001952628 @default.
- W3202541877 cites W2017830127 @default.
- W3202541877 cites W2019554063 @default.
- W3202541877 cites W2020887697 @default.
- W3202541877 cites W2022470580 @default.
- W3202541877 cites W2023666964 @default.
- W3202541877 cites W2044170564 @default.
- W3202541877 cites W2055524735 @default.
- W3202541877 cites W2060536994 @default.
- W3202541877 cites W2065697579 @default.
- W3202541877 cites W2068119597 @default.
- W3202541877 cites W2068658474 @default.
- W3202541877 cites W2072462631 @default.
- W3202541877 cites W2075682801 @default.
- W3202541877 cites W2089771991 @default.
- W3202541877 cites W2093763120 @default.
- W3202541877 cites W2096921306 @default.
- W3202541877 cites W2134729461 @default.
- W3202541877 cites W2134845552 @default.
- W3202541877 cites W2142242761 @default.
- W3202541877 cites W2148898943 @default.
- W3202541877 cites W2168272960 @default.
- W3202541877 cites W2280077905 @default.
- W3202541877 cites W2340192487 @default.
- W3202541877 cites W2395559438 @default.
- W3202541877 cites W2411619501 @default.
- W3202541877 cites W2537351581 @default.
- W3202541877 cites W2568954699 @default.
- W3202541877 cites W2590458460 @default.
- W3202541877 cites W2597739224 @default.
- W3202541877 cites W2613092513 @default.
- W3202541877 cites W2619613367 @default.
- W3202541877 cites W2729232280 @default.
- W3202541877 cites W2742992776 @default.
- W3202541877 cites W2791700208 @default.
- W3202541877 cites W2807609377 @default.
- W3202541877 cites W2896097526 @default.
- W3202541877 cites W2902222116 @default.
- W3202541877 cites W2902840690 @default.
- W3202541877 cites W2904521686 @default.
- W3202541877 cites W2908648017 @default.
- W3202541877 cites W2918223507 @default.
- W3202541877 cites W2921931452 @default.
- W3202541877 cites W2972007441 @default.
- W3202541877 cites W2975922897 @default.
- W3202541877 cites W2994615204 @default.
- W3202541877 cites W3005382457 @default.
- W3202541877 cites W3009614145 @default.
- W3202541877 doi "https://doi.org/10.1101/2021.09.26.461831" @default.
- W3202541877 hasPublicationYear "2021" @default.
- W3202541877 type Work @default.
- W3202541877 sameAs 3202541877 @default.
- W3202541877 citedByCount "1" @default.
- W3202541877 countsByYear W32025418772022 @default.
- W3202541877 crossrefType "posted-content" @default.
- W3202541877 hasAuthorship W3202541877A5001524034 @default.
- W3202541877 hasAuthorship W3202541877A5011156831 @default.
- W3202541877 hasAuthorship W3202541877A5032557530 @default.
- W3202541877 hasAuthorship W3202541877A5057261755 @default.
- W3202541877 hasAuthorship W3202541877A5065624209 @default.
- W3202541877 hasAuthorship W3202541877A5066227014 @default.
- W3202541877 hasBestOaLocation W32025418771 @default.
- W3202541877 hasConcept C126322002 @default.
- W3202541877 hasConcept C127413603 @default.
- W3202541877 hasConcept C142724271 @default.
- W3202541877 hasConcept C169760540 @default.
- W3202541877 hasConcept C2776914184 @default.
- W3202541877 hasConcept C2779830541 @default.
- W3202541877 hasConcept C2780062018 @default.
- W3202541877 hasConcept C2780645631 @default.
- W3202541877 hasConcept C2781156865 @default.
- W3202541877 hasConcept C513476851 @default.
- W3202541877 hasConcept C71924100 @default.
- W3202541877 hasConcept C74254510 @default.
- W3202541877 hasConcept C78519656 @default.
- W3202541877 hasConcept C86803240 @default.
- W3202541877 hasConceptScore W3202541877C126322002 @default.
- W3202541877 hasConceptScore W3202541877C127413603 @default.
- W3202541877 hasConceptScore W3202541877C142724271 @default.
- W3202541877 hasConceptScore W3202541877C169760540 @default.
- W3202541877 hasConceptScore W3202541877C2776914184 @default.
- W3202541877 hasConceptScore W3202541877C2779830541 @default.