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- W3202697207 endingPage "2028" @default.
- W3202697207 startingPage "2028" @default.
- W3202697207 abstract "Plant in vitro cultures, including hairy roots, can be applied for controlled production of valuable natural products, such as triterpenoids and sterols. These compounds originate from the common precursor squalene. Sterols and triterpenoids distinctly differ in their functions, and the 2,3-oxidosqualene cyclization step is often regarded as a branch point between primary and secondary (more aptly: general and specialized) metabolism. Considering the crucial role of phytosterols as membrane constituents, it has been postulated that unconstrained biosynthesis of triterpenoids can occur when sterol formation is already satisfied, and these compounds are no longer needed for cell growth and division. This hypothesis seems to follow directly the growth-defense trade-off plant dilemma. In this review, we present some examples illustrating the specific interplay between the two divergent pathways for sterol and triterpenoid biosynthesis appearing in root cultures. These studies were significant for revealing the steps of the biosynthetic pathway, understanding the role of particular enzymes, and discovering the possibility of gene regulation. Currently, hairy roots of many plant species can be considered not only as an efficient tool for production of phytochemicals, but also as suitable experimental models for investigations on regulatory mechanisms of plant metabolism." @default.
- W3202697207 created "2021-10-11" @default.
- W3202697207 creator A5029193009 @default.
- W3202697207 creator A5061053859 @default.
- W3202697207 date "2021-09-27" @default.
- W3202697207 modified "2023-10-02" @default.
- W3202697207 title "Enhancement of Phytosterol and Triterpenoid Production in Plant Hairy Root Cultures—Simultaneous Stimulation or Competition?" @default.
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- W3202697207 doi "https://doi.org/10.3390/plants10102028" @default.
- W3202697207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8541584" @default.
- W3202697207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34685836" @default.
- W3202697207 hasPublicationYear "2021" @default.
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