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- W3206444445 abstract "The unique properties of fluorine atom on nucleic acid backbone can offer stricking functional and structural features. In order to extend the biological applications of L-type nucleic acid, we chemically incorporate the fluoro-modification into 2′-position of L-cytidine, and obtain a series of fluoro-modified L-DNAs/ L-RNAs. Our melting study indicates that the 2′-fluoro-modification does not disrupt the thermostabilities of wild-type L-nucleic acids. Consistently, our X-ray crystal structure reveals that fluoro-moiety cause no structural perturbation, and the fluoro-L-cytidine forms the Watson-Crick base pair with L-guanosine virtually identical to nonmodified L-type CG pair. This fluoro-modified cytidine provides a useful biochemical strategy to investigate L-nucleic acid as advanced molecular therapy." @default.
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- W3206444445 date "2021-10-18" @default.
- W3206444445 modified "2023-10-01" @default.
- W3206444445 title "Synthesis of 2′‐Deoxy‐2′‐fluoro‐ <scp>L</scp> ‐cytidine and Fluorinated <scp>L</scp> ‐Nucleic Acids for Structural Studies" @default.
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- W3206444445 doi "https://doi.org/10.1002/slct.202103202" @default.
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