FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206615564> ?p ?o ?g. }

• W3206615564 endingPage "478" @default.
• W3206615564 startingPage "473" @default.
• W3206615564 abstract "The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20-30 cancer genes1-8. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver disease9-13 than in normal liver13-16, which enables positive selection to shape the genomic landscape9-13. Here we analysed somatic mutations from 1,590 genomes across 34 liver samples, including healthy controls, alcohol-related liver disease and non-alcoholic fatty liver disease. Seven of the 29 patients with liver disease had mutations in FOXO1, the major transcription factor in insulin signalling. These mutations affected a single hotspot within the gene, impairing the insulin-mediated nuclear export of FOXO1. Notably, six of the seven patients with FOXO1S22W hotspot mutations showed convergent evolution, with variants acquired independently by up to nine distinct hepatocyte clones per patient. CIDEB, which regulates lipid droplet metabolism in hepatocytes17-19, and GPAM, which produces storage triacylglycerol from free fatty acids20,21, also had a significant excess of mutations. We again observed frequent convergent evolution: up to fourteen independent clones per patient with CIDEB mutations and up to seven clones per patient with GPAM mutations. Mutations in metabolism genes were distributed across multiple anatomical segments of the liver, increased clone size and were seen in both alcohol-related liver disease and non-alcoholic fatty liver disease, but rarely in hepatocellular carcinoma. Master regulators of metabolic pathways are a frequent target of convergent somatic mutation in alcohol-related and non-alcoholic fatty liver disease." @default.
• W3206615564 created "2021-10-25" @default.
• W3206615564 creator A5005229861 @default.
• W3206615564 creator A5007140000 @default.
• W3206615564 creator A5007312378 @default.
• W3206615564 creator A5008216381 @default.
• W3206615564 creator A5011152441 @default.
• W3206615564 creator A5013887971 @default.
• W3206615564 creator A5020652950 @default.
• W3206615564 creator A5020879914 @default.
• W3206615564 creator A5025784970 @default.
• W3206615564 creator A5026738636 @default.
• W3206615564 creator A5027369208 @default.
• W3206615564 creator A5027876619 @default.
• W3206615564 creator A5028508024 @default.
• W3206615564 creator A5036787245 @default.
• W3206615564 creator A5046527121 @default.
• W3206615564 creator A5049338088 @default.
• W3206615564 creator A5050416337 @default.
• W3206615564 creator A5053276768 @default.
• W3206615564 creator A5054617785 @default.
• W3206615564 creator A5058103562 @default.
• W3206615564 creator A5058208718 @default.
• W3206615564 creator A5062249209 @default.
• W3206615564 creator A5065109067 @default.
• W3206615564 creator A5067780711 @default.
• W3206615564 creator A5070507977 @default.
• W3206615564 creator A5070897999 @default.
• W3206615564 creator A5074884237 @default.
• W3206615564 creator A5076250197 @default.
• W3206615564 creator A5076898629 @default.
• W3206615564 creator A5083239716 @default.
• W3206615564 creator A5088052945 @default.
• W3206615564 date "2021-10-13" @default.
• W3206615564 modified "2023-10-17" @default.
• W3206615564 title "Convergent somatic mutations in metabolism genes in chronic liver disease" @default.
• W3206615564 cites W1981900811 @default.
• W3206615564 cites W2018851752 @default.
• W3206615564 cites W2026497980 @default.
• W3206615564 cites W2031709894 @default.
• W3206615564 cites W2031934416 @default.
• W3206615564 cites W2041237942 @default.
• W3206615564 cites W2048177238 @default.
• W3206615564 cites W2065913635 @default.
• W3206615564 cites W2067740038 @default.
• W3206615564 cites W2068097474 @default.
• W3206615564 cites W2068127752 @default.
• W3206615564 cites W2071075259 @default.
• W3206615564 cites W2071168599 @default.
• W3206615564 cites W2077256608 @default.
• W3206615564 cites W2082201195 @default.
• W3206615564 cites W2093824918 @default.
• W3206615564 cites W2108698786 @default.
• W3206615564 cites W2109948920 @default.
• W3206615564 cites W2109991075 @default.
• W3206615564 cites W2114104545 @default.
• W3206615564 cites W2115876819 @default.
• W3206615564 cites W2138207763 @default.
• W3206615564 cites W2144673831 @default.
• W3206615564 cites W2148241659 @default.
• W3206615564 cites W2195516528 @default.
• W3206615564 cites W2217642920 @default.
• W3206615564 cites W2324488473 @default.
• W3206615564 cites W2518194013 @default.
• W3206615564 cites W2524881570 @default.
• W3206615564 cites W2564735272 @default.
• W3206615564 cites W2611387862 @default.
• W3206615564 cites W2614501474 @default.
• W3206615564 cites W2625559053 @default.
• W3206615564 cites W2749112473 @default.
• W3206615564 cites W2766220272 @default.
• W3206615564 cites W2808566549 @default.
• W3206615564 cites W2810423511 @default.
• W3206615564 cites W2913327035 @default.
• W3206615564 cites W2929496863 @default.
• W3206615564 cites W2948371032 @default.
• W3206615564 cites W2959211930 @default.
• W3206615564 cites W2970967145 @default.
• W3206615564 cites W2981329637 @default.
• W3206615564 cites W3003287673 @default.
• W3206615564 cites W3003949123 @default.
• W3206615564 cites W3004480399 @default.
• W3206615564 cites W3004859565 @default.
• W3206615564 cites W3005408539 @default.
• W3206615564 cites W3112564450 @default.
• W3206615564 cites W3163276782 @default.
• W3206615564 doi "https://doi.org/10.1038/s41586-021-03974-6" @default.
• W3206615564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34646017" @default.
• W3206615564 hasPublicationYear "2021" @default.
• W3206615564 type Work @default.
• W3206615564 sameAs 3206615564 @default.
• W3206615564 citedByCount "59" @default.
• W3206615564 countsByYear W32066155642021 @default.
• W3206615564 countsByYear W32066155642022 @default.
• W3206615564 countsByYear W32066155642023 @default.
• W3206615564 crossrefType "journal-article" @default.
• W3206615564 hasAuthorship W3206615564A5005229861 @default.
• W3206615564 hasAuthorship W3206615564A5007140000 @default.

• next