FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208157199> ?p ?o ?g. }

• W3208157199 endingPage "364" @default.
• W3208157199 startingPage "355" @default.
• W3208157199 abstract "Cognitive dysfunction is increasingly recognized as an important comorbidity of type 2 diabetes (T2D). We aimed to establish if the risk of accelerated cognitive decline (ACD) is higher in females with T2D than males.3163 participants (38% female) with T2D from the cognition substudy of CAROLINA® (NCT01243424) were included (mean age 64.4 ± 9.2 years; T2D duration 7.6 ± 6.1 years). The cognitive outcome was occurrence of ACD at end of follow-up, defined as a regression based index score ≤16th percentile on either the Mini-Mental State Examination (MMSE) or a composite measure of attention and executive functioning (Trail Making and Verbal Fluency Test). Potential confounders, were taken into account at an individual patient level. Logistic regression analysis was used to investigate ACD risk by sex. We assessed potential mediators for sex differences in ACD using Causal Mediation Analysis (CMA). After a median follow-up duration of 6.1 ± 0.7 years, 361 (30.0%) females compared to 494 (25.2%) males exhibited ACD (OR 1.27 [95%CI 1.08-1.49], p = .003). Depressive symptoms, which were more common in females (24.3% vs 12.5%), mediated between sex and ACD (mediation effect 20.3%, p = 0.03). There were no other significant mediators.Females with T2D had a higher risk of ACD compared to males. This was partly explained by depressive symptoms. After evaluation of vascular and diabetes-related risk factors, complications and treatment, a major share of the higher risk of ACD in females remained unexplained. Our results highlight the need for further research on causes of sex-specific ACD in T2D." @default.
• W3208157199 created "2021-11-08" @default.
• W3208157199 creator A5008842761 @default.
• W3208157199 creator A5026766317 @default.
• W3208157199 creator A5028587177 @default.
• W3208157199 creator A5072184341 @default.
• W3208157199 creator A5073315595 @default.
• W3208157199 date "2022-02-01" @default.
• W3208157199 modified "2023-10-05" @default.
• W3208157199 title "Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study" @default.
• W3208157199 cites W1590815977 @default.
• W3208157199 cites W1847168837 @default.
• W3208157199 cites W1971310460 @default.
• W3208157199 cites W1973403495 @default.
• W3208157199 cites W1983321019 @default.
• W3208157199 cites W1991503413 @default.
• W3208157199 cites W1997614484 @default.
• W3208157199 cites W2002257186 @default.
• W3208157199 cites W2003905926 @default.
• W3208157199 cites W2004032034 @default.
• W3208157199 cites W2004371621 @default.
• W3208157199 cites W2006932083 @default.
• W3208157199 cites W2007473119 @default.
• W3208157199 cites W2013127060 @default.
• W3208157199 cites W2017930909 @default.
• W3208157199 cites W2018358125 @default.
• W3208157199 cites W2051026082 @default.
• W3208157199 cites W2054881009 @default.
• W3208157199 cites W2078305076 @default.
• W3208157199 cites W2093220018 @default.
• W3208157199 cites W2096418171 @default.
• W3208157199 cites W2097522066 @default.
• W3208157199 cites W2104057213 @default.
• W3208157199 cites W2112778345 @default.
• W3208157199 cites W2112887830 @default.
• W3208157199 cites W2113736465 @default.
• W3208157199 cites W2124386285 @default.
• W3208157199 cites W2132072073 @default.
• W3208157199 cites W2133596089 @default.
• W3208157199 cites W2150037324 @default.
• W3208157199 cites W2211614117 @default.
• W3208157199 cites W2529213874 @default.
• W3208157199 cites W2551111288 @default.
• W3208157199 cites W2743088090 @default.
• W3208157199 cites W2782868584 @default.
• W3208157199 cites W2800849195 @default.
• W3208157199 cites W2802967288 @default.
• W3208157199 cites W2808227793 @default.
• W3208157199 cites W2828406404 @default.
• W3208157199 cites W2884234047 @default.
• W3208157199 cites W2930625838 @default.
• W3208157199 cites W2972370316 @default.
• W3208157199 cites W2974098728 @default.
• W3208157199 cites W2980682961 @default.
• W3208157199 cites W2999824588 @default.
• W3208157199 cites W3016435336 @default.
• W3208157199 cites W4292811746 @default.
• W3208157199 doi "https://doi.org/10.1016/j.numecd.2021.10.013" @default.
• W3208157199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34895804" @default.
• W3208157199 hasPublicationYear "2022" @default.
• W3208157199 type Work @default.
• W3208157199 sameAs 3208157199 @default.
• W3208157199 citedByCount "10" @default.
• W3208157199 countsByYear W32081571992022 @default.
• W3208157199 countsByYear W32081571992023 @default.
• W3208157199 crossrefType "journal-article" @default.
• W3208157199 hasAuthorship W3208157199A5008842761 @default.
• W3208157199 hasAuthorship W3208157199A5026766317 @default.
• W3208157199 hasAuthorship W3208157199A5028587177 @default.
• W3208157199 hasAuthorship W3208157199A5072184341 @default.
• W3208157199 hasAuthorship W3208157199A5073315595 @default.
• W3208157199 hasBestOaLocation W32081571991 @default.
• W3208157199 hasConcept C118552586 @default.
• W3208157199 hasConcept C126322002 @default.
• W3208157199 hasConcept C134018914 @default.
• W3208157199 hasConcept C144024400 @default.
• W3208157199 hasConcept C149923435 @default.
• W3208157199 hasConcept C151956035 @default.
• W3208157199 hasConcept C169900460 @default.
• W3208157199 hasConcept C17744445 @default.
• W3208157199 hasConcept C179420905 @default.
• W3208157199 hasConcept C199539241 @default.
• W3208157199 hasConcept C2777180221 @default.
• W3208157199 hasConcept C2779134260 @default.
• W3208157199 hasConcept C2779483572 @default.
• W3208157199 hasConcept C2984863031 @default.
• W3208157199 hasConcept C555293320 @default.
• W3208157199 hasConcept C71924100 @default.
• W3208157199 hasConcept C77350462 @default.
• W3208157199 hasConceptScore W3208157199C118552586 @default.
• W3208157199 hasConceptScore W3208157199C126322002 @default.
• W3208157199 hasConceptScore W3208157199C134018914 @default.
• W3208157199 hasConceptScore W3208157199C144024400 @default.
• W3208157199 hasConceptScore W3208157199C149923435 @default.
• W3208157199 hasConceptScore W3208157199C151956035 @default.
• W3208157199 hasConceptScore W3208157199C169900460 @default.
• W3208157199 hasConceptScore W3208157199C17744445 @default.
• W3208157199 hasConceptScore W3208157199C179420905 @default.

• next