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- W3208308395 abstract "Background Intermittent catheterisation (IC) is a commonly recommended procedure for people with incomplete bladder emptying. Frequent complications are urinary tract infection (UTI), urethral trauma and discomfort during catheter use. Despite the many designs of intermittent catheter, including different lengths, materials and coatings, it is unclear which catheter techniques, strategies or designs affect the incidence of UTI and other complications, measures of satisfaction/quality of life and cost‐effectiveness. This is an update of a Cochrane Review first published in 2007. Objectives To assess the clinical and cost‐effectiveness of different catheterisation techniques, strategies and catheter designs, and their impact, on UTI and other complications, and measures of satisfaction/quality of life among adults and children whose long‐term bladder condition is managed by intermittent catheterisation. Search methods We searched the Cochrane Incontinence Specialised Register, which contains trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In‐Process, MEDLINE Epub Ahead of Print, CINAHL, ClinicalTrials.gov, WHO ICTRP and handsearching of journals and conference proceedings (searched 12 April 2021), the reference lists of relevant articles and conference proceedings, and we attempted to contact other investigators for unpublished data or for clarification. Selection criteria Randomised controlled trials (RCTs) or randomised cross‐over trials comparing at least two different catheterisation techniques, strategies or catheter designs. Data collection and analysis As per standard Cochrane methodological procedures, two review authors independently extracted data, assessed risk of bias and assessed the certainty of evidence using GRADE. Outcomes included the number of people with symptomatic urinary tract infections, complications such as urethral trauma/bleeding, comfort and ease of use of catheters, participant satisfaction and preference, quality of life measures and economic outcomes. Main results We included 23 trials (1339 randomised participants), including twelve RCTs and eleven cross‐over trials. Most were small (fewer than 60 participants completed), although three trials had more than 100 participants. Length of follow‐up ranged from one month to 12 months and there was considerable variation in definitions of UTI. Most of the data from cross‐over trials were not presented in a useable form for this review. Risk of bias was unclear in many domains due to insufficient information in the trial reports and several trials were judged to have a high risk of performance bias due to lack of blinding and a high risk of attrition bias. The certainty of evidence was downgraded for risk of bias, and imprecision due to low numbers of participants. Aseptic versus clean technique We are uncertain if there is any difference between aseptic and clean techniques in the risk of symptomatic UTI because the evidence is low‐certainty and the 95% confidence interval (CI) is consistent with possible benefit and possible harm (RR 1.20 95% CI 0.54 to 2.66; one study; 36 participants). We identified no data relating to the risk of adverse events comparing aseptic and clean techniques or participant satisfaction or preference. Single‐use (sterile) catheter versus multiple‐use (clean) We are uncertain if there is any difference between single‐use and multiple‐use catheters in terms of the risk of symptomatic UTI because the certainty of evidence is low and the 95% CI is consistent with possible benefit and possible harm (RR 0.98, 95% CI 0.55, 1.74; two studies; 97 participants). One study comparing single‐use catheters to multiple‐use catheters reported zero adverse events in either group; no other adverse event data were reported for this comparison. We identified no data for participant satisfaction or preference. Hydrophilic‐coated catheters versus uncoated catheters We are uncertain if there is any difference between hydrophilic and uncoated catheters in terms of the number of people with symptomatic UTI because the certainty of evidence is low and the 95% CI is consistent with possible benefit and possible harm (RR 0.89, 95% CI 0.69 to 1.14; two studies; 98 participants). Uncoated catheters probably slightly reduce the risk of urethral trauma and bleeding compared to hydrophilic‐coated catheters (RR 1.37, 95% CI 1.01 to 1.87; moderate‐certainty evidence). The evidence is uncertain if hydrophilic‐coated catheters compared with uncoated catheters has any effect on participant satisfaction measured on a 0‐10 scale (MD 0.7 higher, 95% CI 0.19 to 1.21; very low‐certainty evidence; one study; 114 participants). Due to the paucity of data, we could not assess the certainty of evidence relating to participant preference (one cross‐over trial of 29 participants reported greater preference for a hydrophilic‐coated catheter (19/29) compared to an uncoated catheter (10/29)). Authors' conclusions Despite a total of 23 trials, the paucity of useable data and uncertainty of the evidence means that it remains unclear whether the incidence of UTI or other complications is affected by use of aseptic or clean technique, single (sterile) or multiple‐use (clean) catheters, coated or uncoated catheters or different catheter lengths. The current research evidence is uncertain and design and reporting issues are significant. More well‐designed trials are needed. Such trials should include analysis of cost‐effectiveness because there are likely to be substantial differences associated with the use of different catheterisation techniques and strategies, and catheter designs." @default.
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- W3208308395 date "2021-10-26" @default.
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- W3208308395 title "Intermittent catheter techniques, strategies and designs for managing long-term bladder conditions" @default.
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- W3208308395 doi "https://doi.org/10.1002/14651858.cd006008.pub5" @default.
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