FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208547680> ?p ?o ?g. }

• W3208547680 abstract "Background: Colorectal cancer (CRC) is the third most common type of cancer, it is considered a genetically heterogeneous disease with different molecular pathways being involved in its initiation and progression. Testes-specific protease 50 (TSP50) gene is a member of cancer/testis antigens that encodes for threonine protease enzyme. Overexpression of TSP50 was found to enhance the progression and invasion of breast cancer and other malignant tumors. SERCA2 is widely expressed in several body tissues; its aberrant expression has been involved in many cancers. IL-8 is an inflammatory cytokine. Alongside its role in inflammation, its expression was reported to induce the migration of tumor cells. Aim: Study the expression of TSP50, SERCA2 and IL-8 in colorectal adenoma (CRA), CRC and normal colonic tissues to compare the expression of these biomarkers in relation to clinicopathological parameters and prognostic factors. Results: TSP50, SERCA2 and IL-8 expression varied between normal colonic tissues, CRA and CRC. Significant statistical association was detected between the three biomarkers' overexpression and degree of dysplasia in CRA. Also, significant statistical relation was found between the three biomarkers' overexpression and presence of lympho-vascular invasion, advanced TNM staging and high intra-tumoral inflammatory infiltrate. Multivariable analysis showed that the overexpression of the three biomarkers is significantly associated with worse prognosis. Conclusion: The expression of TSP50, SERCA2 and IL-8 was different between the normal tissue and neoplastic colorectal tissue on one hand and between CRA and CRC on the other. Increased expression of these biomarkers in neoplastic epithelial cells of colorectal carcinoma is associated with adverse prognostic factors and could be considered as independent prognostic factors." @default.
• W3208547680 created "2021-11-08" @default.
• W3208547680 creator A5025576130 @default.
• W3208547680 creator A5032492484 @default.
• W3208547680 creator A5069514804 @default.
• W3208547680 date "2021-10-21" @default.
• W3208547680 modified "2023-10-14" @default.
• W3208547680 title "Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors" @default.
• W3208547680 cites W1482765058 @default.
• W3208547680 cites W1565900869 @default.
• W3208547680 cites W1934094702 @default.
• W3208547680 cites W1953598538 @default.
• W3208547680 cites W1965065360 @default.
• W3208547680 cites W1966527204 @default.
• W3208547680 cites W1968749916 @default.
• W3208547680 cites W1975108860 @default.
• W3208547680 cites W1989490036 @default.
• W3208547680 cites W2014761304 @default.
• W3208547680 cites W2027137258 @default.
• W3208547680 cites W2034221489 @default.
• W3208547680 cites W2043434733 @default.
• W3208547680 cites W2046618178 @default.
• W3208547680 cites W2046646461 @default.
• W3208547680 cites W2052464502 @default.
• W3208547680 cites W2059350883 @default.
• W3208547680 cites W2062252219 @default.
• W3208547680 cites W2073673926 @default.
• W3208547680 cites W2104469469 @default.
• W3208547680 cites W2125063590 @default.
• W3208547680 cites W2151686792 @default.
• W3208547680 cites W2172267807 @default.
• W3208547680 cites W2173877678 @default.
• W3208547680 cites W2176487098 @default.
• W3208547680 cites W2182573625 @default.
• W3208547680 cites W2275889027 @default.
• W3208547680 cites W2332258267 @default.
• W3208547680 cites W2342600311 @default.
• W3208547680 cites W2604326916 @default.
• W3208547680 cites W2785099294 @default.
• W3208547680 cites W2795105142 @default.
• W3208547680 cites W2885000560 @default.
• W3208547680 cites W2888058132 @default.
• W3208547680 cites W2896593432 @default.
• W3208547680 cites W2900911711 @default.
• W3208547680 cites W2914914225 @default.
• W3208547680 cites W2946473626 @default.
• W3208547680 cites W2965492019 @default.
• W3208547680 cites W2967930723 @default.
• W3208547680 cites W2990302286 @default.
• W3208547680 cites W3008227704 @default.
• W3208547680 cites W3082050978 @default.
• W3208547680 cites W4206384507 @default.
• W3208547680 cites W4249818367 @default.
• W3208547680 doi "https://doi.org/10.3389/pore.2021.1609990" @default.
• W3208547680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8566330" @default.
• W3208547680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34744521" @default.
• W3208547680 hasPublicationYear "2021" @default.
• W3208547680 type Work @default.
• W3208547680 sameAs 3208547680 @default.
• W3208547680 citedByCount "2" @default.
• W3208547680 countsByYear W32085476802022 @default.
• W3208547680 countsByYear W32085476802023 @default.
• W3208547680 crossrefType "journal-article" @default.
• W3208547680 hasAuthorship W3208547680A5025576130 @default.
• W3208547680 hasAuthorship W3208547680A5032492484 @default.
• W3208547680 hasAuthorship W3208547680A5069514804 @default.
• W3208547680 hasBestOaLocation W32085476801 @default.
• W3208547680 hasConcept C121608353 @default.
• W3208547680 hasConcept C126322002 @default.
• W3208547680 hasConcept C142724271 @default.
• W3208547680 hasConcept C143998085 @default.
• W3208547680 hasConcept C204232928 @default.
• W3208547680 hasConcept C2775894508 @default.
• W3208547680 hasConcept C2776861080 @default.
• W3208547680 hasConcept C2776914184 @default.
• W3208547680 hasConcept C2777428134 @default.
• W3208547680 hasConcept C2777546739 @default.
• W3208547680 hasConcept C502942594 @default.
• W3208547680 hasConcept C526805850 @default.
• W3208547680 hasConcept C71924100 @default.
• W3208547680 hasConceptScore W3208547680C121608353 @default.
• W3208547680 hasConceptScore W3208547680C126322002 @default.
• W3208547680 hasConceptScore W3208547680C142724271 @default.
• W3208547680 hasConceptScore W3208547680C143998085 @default.
• W3208547680 hasConceptScore W3208547680C204232928 @default.
• W3208547680 hasConceptScore W3208547680C2775894508 @default.
• W3208547680 hasConceptScore W3208547680C2776861080 @default.
• W3208547680 hasConceptScore W3208547680C2776914184 @default.
• W3208547680 hasConceptScore W3208547680C2777428134 @default.
• W3208547680 hasConceptScore W3208547680C2777546739 @default.
• W3208547680 hasConceptScore W3208547680C502942594 @default.
• W3208547680 hasConceptScore W3208547680C526805850 @default.
• W3208547680 hasConceptScore W3208547680C71924100 @default.
• W3208547680 hasLocation W32085476801 @default.
• W3208547680 hasLocation W32085476802 @default.
• W3208547680 hasLocation W32085476803 @default.
• W3208547680 hasLocation W32085476804 @default.
• W3208547680 hasOpenAccess W3208547680 @default.
• W3208547680 hasPrimaryLocation W32085476801 @default.
• W3208547680 hasRelatedWork W2007740888 @default.

• next