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- W3669110 abstract "This chapter examines the interferon (IFN) production and natural cytotoxicity by human lymphocytes fractionated by percoll density gradient centrifugation. Interferons are potent immunoregulatory molecules, which are produced by most nucleated cells. Their stimulatory effect for natural cell-mediated cytotoxicity has been well documented. Human IFN have been classified into fibroblast/leukocyte and immune types/depending upon the cells producing them and according to their physical, biological, and antigenic characteristics. In a stud described in the chapter, peripheral blood lymphocytes were obtained from two different donors, and subpopulations were obtained by Percoll density gradient centrifugation. The donors were selected for their weak and strong cytotoxicity against K562 target cells. The chapter presents the results obtained with lymphocytes from the donor reacting weakly against K562. The antiviral activity of IFN was assayed using vesicular stomatitis virus and G-11 cells in Microtest I plates. The data show that the cytotoxic activity was strongest in fraction I, with declining activity toward the bottom of the gradient. The densest fraction exhibited a slight increase in activity against K562 compared to the fractions immediately above it. IFN production was greatest among the lighter cells harvested from the top of the gradient." @default.
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- W3669110 date "1982-01-01" @default.
- W3669110 modified "2023-09-25" @default.
- W3669110 title "INTERFERON PRODUCTION AND NATURAL CYTOTOXICITY BY HUMAN LYMPHOCYTES FRACTIONATED BY PERCOLL DENSITY GRADIENT CENTRIFUGATION" @default.
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- W3669110 doi "https://doi.org/10.1016/b978-0-12-341360-4.50105-0" @default.
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