Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200411318> ?p ?o ?g. }
- W4200411318 endingPage "2795" @default.
- W4200411318 startingPage "2787" @default.
- W4200411318 abstract "The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitochondrial apoptosis is a common feature of cancer cells, targeting protein–protein interactions within the BCL-2 protein family is a key strategy to seize control of apoptosis and provide favourable outcomes for cancer patients. Non-BCL-2 family proteins are emerging as novel regulators of apoptosis and are potential drug targets. Voltage dependent anion channel 2 (VDAC2) can regulate apoptosis. However, it is unclear how this occurs at the molecular level, with conflicting evidence in the literature for its role in regulating the BCL-2 effector proteins, BAK and BAX. Notably, VDAC2 is required for efficient BAX-mediated apoptosis, but conversely inhibits BAK-mediated apoptosis. This review focuses on the role of VDAC2 in apoptosis, discussing the current knowledge of the interaction between VDAC2 and BCL-2 family proteins and the recent development of an apoptosis inhibitor that targets the VDAC2–BAK interaction." @default.
- W4200411318 created "2021-12-31" @default.
- W4200411318 creator A5058313554 @default.
- W4200411318 creator A5060741395 @default.
- W4200411318 creator A5063424737 @default.
- W4200411318 creator A5073982345 @default.
- W4200411318 date "2021-12-16" @default.
- W4200411318 modified "2023-10-13" @default.
- W4200411318 title "VDAC2 and the BCL-2 family of proteins" @default.
- W4200411318 cites W1644794975 @default.
- W4200411318 cites W1768391433 @default.
- W4200411318 cites W1971840691 @default.
- W4200411318 cites W1978631786 @default.
- W4200411318 cites W1978974783 @default.
- W4200411318 cites W1979513962 @default.
- W4200411318 cites W1984785146 @default.
- W4200411318 cites W1986199954 @default.
- W4200411318 cites W1988917342 @default.
- W4200411318 cites W199440580 @default.
- W4200411318 cites W1995354282 @default.
- W4200411318 cites W1998225262 @default.
- W4200411318 cites W2001389093 @default.
- W4200411318 cites W2008597649 @default.
- W4200411318 cites W2010541165 @default.
- W4200411318 cites W2012076962 @default.
- W4200411318 cites W2013274986 @default.
- W4200411318 cites W2020418292 @default.
- W4200411318 cites W2023461553 @default.
- W4200411318 cites W2026873116 @default.
- W4200411318 cites W2027069808 @default.
- W4200411318 cites W2032366675 @default.
- W4200411318 cites W2034332995 @default.
- W4200411318 cites W2035759514 @default.
- W4200411318 cites W2040155866 @default.
- W4200411318 cites W2054645758 @default.
- W4200411318 cites W2056989927 @default.
- W4200411318 cites W2057257618 @default.
- W4200411318 cites W2063418623 @default.
- W4200411318 cites W2063420509 @default.
- W4200411318 cites W2068444709 @default.
- W4200411318 cites W2069867390 @default.
- W4200411318 cites W2078915131 @default.
- W4200411318 cites W2081490942 @default.
- W4200411318 cites W2086782603 @default.
- W4200411318 cites W2088805436 @default.
- W4200411318 cites W2088883749 @default.
- W4200411318 cites W2092378641 @default.
- W4200411318 cites W2098713453 @default.
- W4200411318 cites W2103619814 @default.
- W4200411318 cites W2110431723 @default.
- W4200411318 cites W2118849726 @default.
- W4200411318 cites W2128985348 @default.
- W4200411318 cites W2129141040 @default.
- W4200411318 cites W2129400842 @default.
- W4200411318 cites W2129739398 @default.
- W4200411318 cites W2130866079 @default.
- W4200411318 cites W2134087185 @default.
- W4200411318 cites W2142713529 @default.
- W4200411318 cites W2150315067 @default.
- W4200411318 cites W2158025958 @default.
- W4200411318 cites W2167182598 @default.
- W4200411318 cites W2192121806 @default.
- W4200411318 cites W2321452523 @default.
- W4200411318 cites W2321985754 @default.
- W4200411318 cites W2344880366 @default.
- W4200411318 cites W2732876755 @default.
- W4200411318 cites W2770278477 @default.
- W4200411318 cites W2901323432 @default.
- W4200411318 cites W2978320847 @default.
- W4200411318 cites W2999044305 @default.
- W4200411318 cites W3000187473 @default.
- W4200411318 cites W3012638502 @default.
- W4200411318 cites W3084489882 @default.
- W4200411318 cites W3092608235 @default.
- W4200411318 cites W3150454900 @default.
- W4200411318 cites W3177828909 @default.
- W4200411318 cites W80462140 @default.
- W4200411318 doi "https://doi.org/10.1042/bst20210753" @default.
- W4200411318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34913469" @default.
- W4200411318 hasPublicationYear "2021" @default.
- W4200411318 type Work @default.
- W4200411318 citedByCount "15" @default.
- W4200411318 countsByYear W42004113182022 @default.
- W4200411318 countsByYear W42004113182023 @default.
- W4200411318 crossrefType "journal-article" @default.
- W4200411318 hasAuthorship W4200411318A5058313554 @default.
- W4200411318 hasAuthorship W4200411318A5060741395 @default.
- W4200411318 hasAuthorship W4200411318A5063424737 @default.
- W4200411318 hasAuthorship W4200411318A5073982345 @default.
- W4200411318 hasBestOaLocation W42004113181 @default.
- W4200411318 hasConcept C104317684 @default.
- W4200411318 hasConcept C146587185 @default.
- W4200411318 hasConcept C149150037 @default.
- W4200411318 hasConcept C171897839 @default.
- W4200411318 hasConcept C185592680 @default.
- W4200411318 hasConcept C190283241 @default.
- W4200411318 hasConcept C200784783 @default.
- W4200411318 hasConcept C28859421 @default.