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• W4214901405 abstract "The rapid spread of COVID-19 has become a health emergency causing an urgent need for drug treatments to control the outbreak, especially in more vulnerable individuals. This is reinforced by the fact that prophylactic vaccines and neutralizing monoclonal antibodies may not be fully effective against emerging variants. Despite all efforts made by the scientific community, efficient therapeutic options currently remain scarce, either in the initial, as well as in the advanced forms of the disease. From retrospective observational studies and prospective clinical trials, selective serotonin reuptake inhibitors (SSRIs), and other antidepressants with functional inhibition of acid sphingomyelinase (FIASMAs), have emerged as potential treatments of COVID-19. This has led to some prematurely optimistic points of view, promoting a large prescription of fluvoxamine in patients with COVID-19, that we think should be reasonably tempered." @default.
• W4214901405 created "2022-03-05" @default.
• W4214901405 creator A5018374160 @default.
• W4214901405 creator A5028252035 @default.
• W4214901405 date "2022-03-03" @default.
• W4214901405 modified "2023-10-18" @default.
• W4214901405 title "Difficulty in Repurposing Selective Serotonin Reuptake Inhibitors and Other Antidepressants with Functional Inhibition of Acid Sphingomyelinase in COVID-19 Infection" @default.
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• W4214901405 doi "https://doi.org/10.3389/fphar.2022.849095" @default.
• W4214901405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35308205" @default.
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