FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220653883> ?p ?o ?g. }

• W4220653883 endingPage "114042" @default.
• W4220653883 startingPage "114042" @default.
• W4220653883 abstract "Current stem cell therapies for Parkinson's disease (PD) focus on a neurorestorative approach that aims to repair the CNS during the symptomatic phase. However, the pleiotropic and supportive effects of human neural stem cells (hNSCs) may make them effective for PD treatment during the disease's earlier stages. In the current study, we investigated the therapeutic effects of transplanting hNSCs during the early stages of PD development when most dopaminergic neurons are still present and before symptoms appear. Previous studies on hNSCs in Parkinson's disease focus on the substantia nigra and its immediate surroundings, but other brain structures are affected in PD as well. Here, we investigated the therapeutic effects of hNSCs on the entire PD-afflicted brain transcriptome using RNA sequencing (RNA-seq).PD was induced with a single intranasal infusion of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and hNSCs were transplanted unilaterally into the striatum one week later. The timepoint for hNSC transplantation coincided with upregulation of endogenous proinflammatory cytokines in the CNS, which play a role in stem cell migration. At 3 weeks post-transplantation (4 weeks post-MPTP), we assessed motor symptoms through behavioral tests, quantified dopaminergic neurons in the substantia nigra, and performed global transcriptional profiling to understand the mechanism underlying the effect of hNSCs on dopaminergic neuron degeneration.We found that early hNSC engraftment mitigated motor symptoms induced by MPTP, and also reduced MPTP-induced loss of dopaminergic neurons. In this study, we uniquely presented the first comprehensive analysis of the effect of hNSC transplantation on the transcriptional profiling of PD mouse brains showing decreased expression of 249 and increased expression of 200 genes. These include genes implicated in mitochondrial bioenergetics, proteostasis, and other signaling pathways associated with improved PD outcome following hNSC transplantation.These findings indicate that NSC transplantation during the asymptomatic phase of PD may limit or halt the progression of this neurodegenerative disorder. Transcriptional profiling of hNSC-engrafted PD mouse brains provides mechanistic insight that could lead to novel approaches to ameliorating degeneration of dopaminergic neurons and improving behavioral dysfunction in PD." @default.
• W4220653883 created "2022-04-03" @default.
• W4220653883 creator A5009793238 @default.
• W4220653883 creator A5009970732 @default.
• W4220653883 creator A5015644405 @default.
• W4220653883 creator A5042645936 @default.
• W4220653883 creator A5054309140 @default.
• W4220653883 creator A5088585172 @default.
• W4220653883 date "2022-06-01" @default.
• W4220653883 modified "2023-09-28" @default.
• W4220653883 title "Reduced dopaminergic neuron degeneration and global transcriptional changes in Parkinson's disease mouse brains engrafted with human neural stems during the early disease stage" @default.
• W4220653883 cites W1884487830 @default.
• W4220653883 cites W1965123424 @default.
• W4220653883 cites W1975759687 @default.
• W4220653883 cites W1981823002 @default.
• W4220653883 cites W1987270591 @default.
• W4220653883 cites W1988173316 @default.
• W4220653883 cites W1988441542 @default.
• W4220653883 cites W1992618202 @default.
• W4220653883 cites W1994687979 @default.
• W4220653883 cites W1995261715 @default.
• W4220653883 cites W1999385317 @default.
• W4220653883 cites W1999574084 @default.
• W4220653883 cites W2000541529 @default.
• W4220653883 cites W2008001474 @default.
• W4220653883 cites W2009706073 @default.
• W4220653883 cites W2009911605 @default.
• W4220653883 cites W2010320413 @default.
• W4220653883 cites W2014150662 @default.
• W4220653883 cites W2017032419 @default.
• W4220653883 cites W2019597880 @default.
• W4220653883 cites W2019935461 @default.
• W4220653883 cites W2022553955 @default.
• W4220653883 cites W2023890073 @default.
• W4220653883 cites W2025922492 @default.
• W4220653883 cites W2026914327 @default.
• W4220653883 cites W2029685821 @default.
• W4220653883 cites W2031874070 @default.
• W4220653883 cites W2032609932 @default.
• W4220653883 cites W2037038846 @default.
• W4220653883 cites W2037111632 @default.
• W4220653883 cites W2045298299 @default.
• W4220653883 cites W2045694545 @default.
• W4220653883 cites W2047417345 @default.
• W4220653883 cites W2048135892 @default.
• W4220653883 cites W2050786534 @default.
• W4220653883 cites W2054415450 @default.
• W4220653883 cites W2054438521 @default.
• W4220653883 cites W2074616189 @default.
• W4220653883 cites W2083628520 @default.
• W4220653883 cites W2088664861 @default.
• W4220653883 cites W2089735370 @default.
• W4220653883 cites W2095270577 @default.
• W4220653883 cites W2096283128 @default.
• W4220653883 cites W2098994600 @default.
• W4220653883 cites W2099540110 @default.
• W4220653883 cites W2107486301 @default.
• W4220653883 cites W2107758668 @default.
• W4220653883 cites W2108851964 @default.
• W4220653883 cites W2118972585 @default.
• W4220653883 cites W2119248458 @default.
• W4220653883 cites W2124227727 @default.
• W4220653883 cites W2126117444 @default.
• W4220653883 cites W2130749065 @default.
• W4220653883 cites W2132333739 @default.
• W4220653883 cites W2138462240 @default.
• W4220653883 cites W2151317627 @default.
• W4220653883 cites W2154761807 @default.
• W4220653883 cites W2160685478 @default.
• W4220653883 cites W2164905816 @default.
• W4220653883 cites W2168702014 @default.
• W4220653883 cites W2169456326 @default.
• W4220653883 cites W2179438025 @default.
• W4220653883 cites W2207405009 @default.
• W4220653883 cites W2310986698 @default.
• W4220653883 cites W2317064904 @default.
• W4220653883 cites W2324759145 @default.
• W4220653883 cites W2334461448 @default.
• W4220653883 cites W2419218151 @default.
• W4220653883 cites W2432815617 @default.
• W4220653883 cites W2592024720 @default.
• W4220653883 cites W2767826728 @default.
• W4220653883 cites W2773982115 @default.
• W4220653883 cites W2783252066 @default.
• W4220653883 cites W2796389302 @default.
• W4220653883 cites W2808420239 @default.
• W4220653883 cites W2811255424 @default.
• W4220653883 cites W2883518236 @default.
• W4220653883 cites W2883627842 @default.
• W4220653883 cites W2891042228 @default.
• W4220653883 cites W2906486676 @default.
• W4220653883 cites W2944572233 @default.
• W4220653883 cites W3010084808 @default.
• W4220653883 cites W3082411453 @default.
• W4220653883 cites W3105564964 @default.
• W4220653883 cites W3186832335 @default.
• W4220653883 cites W3211627129 @default.
• W4220653883 cites W37005 @default.

• next