FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220669073> ?p ?o ?g. }

• W4220669073 endingPage "158" @default.
• W4220669073 startingPage "150" @default.
• W4220669073 abstract "New strategies to increase the immune response to HIV-1 vaccine using immunological adjuvants such as Toll-like receptor agonists are needed. In this study, HIV-1 p24-Nef and conjugated form of the vaccine candidate to type-A flagellin (FLA) were injected in the BALB/c mice in different routes. Two weeks after the last immunization, lymphocyte proliferation was measured by the BrdU method. The IL-4 and IFN-γ levels, as well as the total IgG antibody and its isotypes titer, were evaluated by the enzyme-linked immunosorbent assay method. The IFN-γ ELISPOT was also performed. Our data showed that the HIV-1 p24-Nef alone and conjugated to type-A flagellin (FLA) significantly increased lymphocyte proliferation responses as well as higher levels of cytokines and IFN-γ producing lymphocytes and the level of humoral immune responses compared with the control groups. The cell-mediated immune responses through the subcutaneous route and humoral immune responses through the intramuscular route were significantly higher in the conjugated form than in the mere vaccine candidate. In conclusion, when the FLA as an adjuvant is constructed in the HIV-1 vaccine candidate, it could effectively improve both humoral and cellular immune responses. Furthermore, modification in the vaccine formulation could change the optimal route of vaccine inoculation." @default.
• W4220669073 created "2022-04-03" @default.
• W4220669073 creator A5005478432 @default.
• W4220669073 creator A5006162107 @default.
• W4220669073 creator A5035972714 @default.
• W4220669073 creator A5038567292 @default.
• W4220669073 creator A5049589069 @default.
• W4220669073 creator A5065844352 @default.
• W4220669073 creator A5072602300 @default.
• W4220669073 creator A5080185559 @default.
• W4220669073 creator A5080537358 @default.
• W4220669073 date "2022-03-01" @default.
• W4220669073 modified "2023-10-16" @default.
• W4220669073 title "Adjuvant Effects of<i>Pseudomonas aeruginosa</i>Flagellin on the Immunological Patterns of the HIV-1 Vaccine Candidate: Vaccine Formulations Versus Different Routes of Immunization" @default.
• W4220669073 cites W1484339392 @default.
• W4220669073 cites W1819802590 @default.
• W4220669073 cites W1845435659 @default.
• W4220669073 cites W1998523591 @default.
• W4220669073 cites W1999316098 @default.
• W4220669073 cites W2003517691 @default.
• W4220669073 cites W2004790475 @default.
• W4220669073 cites W2005513649 @default.
• W4220669073 cites W2012702409 @default.
• W4220669073 cites W2014225473 @default.
• W4220669073 cites W2018411984 @default.
• W4220669073 cites W2020922034 @default.
• W4220669073 cites W2021359036 @default.
• W4220669073 cites W2032294136 @default.
• W4220669073 cites W2032521949 @default.
• W4220669073 cites W2037894708 @default.
• W4220669073 cites W2040699102 @default.
• W4220669073 cites W2045628772 @default.
• W4220669073 cites W2054234238 @default.
• W4220669073 cites W2062153264 @default.
• W4220669073 cites W2065080800 @default.
• W4220669073 cites W2088667516 @default.
• W4220669073 cites W2089842856 @default.
• W4220669073 cites W2097829667 @default.
• W4220669073 cites W2111593523 @default.
• W4220669073 cites W2141304440 @default.
• W4220669073 cites W2149408708 @default.
• W4220669073 cites W2155666359 @default.
• W4220669073 cites W2604297371 @default.
• W4220669073 cites W2610639910 @default.
• W4220669073 cites W2771277947 @default.
• W4220669073 cites W2921693673 @default.
• W4220669073 cites W3038037714 @default.
• W4220669073 cites W3156786029 @default.
• W4220669073 doi "https://doi.org/10.1089/vim.2021.0143" @default.
• W4220669073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35319970" @default.
• W4220669073 hasPublicationYear "2022" @default.
• W4220669073 type Work @default.
• W4220669073 citedByCount "0" @default.
• W4220669073 crossrefType "journal-article" @default.
• W4220669073 hasAuthorship W4220669073A5005478432 @default.
• W4220669073 hasAuthorship W4220669073A5006162107 @default.
• W4220669073 hasAuthorship W4220669073A5035972714 @default.
• W4220669073 hasAuthorship W4220669073A5038567292 @default.
• W4220669073 hasAuthorship W4220669073A5049589069 @default.
• W4220669073 hasAuthorship W4220669073A5065844352 @default.
• W4220669073 hasAuthorship W4220669073A5072602300 @default.
• W4220669073 hasAuthorship W4220669073A5080185559 @default.
• W4220669073 hasAuthorship W4220669073A5080537358 @default.
• W4220669073 hasConcept C159047783 @default.
• W4220669073 hasConcept C159654299 @default.
• W4220669073 hasConcept C170493617 @default.
• W4220669073 hasConcept C203014093 @default.
• W4220669073 hasConcept C22070199 @default.
• W4220669073 hasConcept C22889606 @default.
• W4220669073 hasConcept C2776090121 @default.
• W4220669073 hasConcept C2776548049 @default.
• W4220669073 hasConcept C2777863537 @default.
• W4220669073 hasConcept C2778190748 @default.
• W4220669073 hasConcept C2779053233 @default.
• W4220669073 hasConcept C2780195530 @default.
• W4220669073 hasConcept C2780801004 @default.
• W4220669073 hasConcept C32611913 @default.
• W4220669073 hasConcept C38117629 @default.
• W4220669073 hasConcept C55493867 @default.
• W4220669073 hasConcept C71924100 @default.
• W4220669073 hasConcept C86803240 @default.
• W4220669073 hasConcept C8891405 @default.
• W4220669073 hasConceptScore W4220669073C159047783 @default.
• W4220669073 hasConceptScore W4220669073C159654299 @default.
• W4220669073 hasConceptScore W4220669073C170493617 @default.
• W4220669073 hasConceptScore W4220669073C203014093 @default.
• W4220669073 hasConceptScore W4220669073C22070199 @default.
• W4220669073 hasConceptScore W4220669073C22889606 @default.
• W4220669073 hasConceptScore W4220669073C2776090121 @default.
• W4220669073 hasConceptScore W4220669073C2776548049 @default.
• W4220669073 hasConceptScore W4220669073C2777863537 @default.
• W4220669073 hasConceptScore W4220669073C2778190748 @default.
• W4220669073 hasConceptScore W4220669073C2779053233 @default.
• W4220669073 hasConceptScore W4220669073C2780195530 @default.
• W4220669073 hasConceptScore W4220669073C2780801004 @default.
• W4220669073 hasConceptScore W4220669073C32611913 @default.
• W4220669073 hasConceptScore W4220669073C38117629 @default.
• W4220669073 hasConceptScore W4220669073C55493867 @default.

• next