Matches in SemOpenAlex for { <https://semopenalex.org/work/W4221061640> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4221061640 endingPage "21" @default.
- W4221061640 startingPage "1" @default.
- W4221061640 abstract "Ovarian cancer (OC) is the most lethal gynecologic cancer. Many studies have reported that RIPK4 (receptor interacting serine/threonine kinase 4) displayed a dysregulated level in many types of tumors. However, its expressions and functions in OC were rarely reported. The levels of RIPK4 were detected in OC and nontumor specimens using TCGA and GEO datasets. The prognostic values of RIPK4 in patients were determined using Kaplan-Meier methods and Kaplan-Meier assays. GO assays and KEGG pathway assays were carried out for functional enrichments. CIBERSORT was applied for estimating the fractions of immune cell types. Finally, RIPK4 was validated in pan-cancer. In this study, our group found that RIPK4 exhibited a higher level of RIPK4 in OC specimens than nontumor specimens. Survival studies revealed that patients with high RIPK4 expressions showed a shorter overall survival than those with low RIPK4 expression. Multivariate assays further confirmed that RIPK4 expression was an independent prognostic element for OC. KEGG pathway analysis displayed that the dysregulated genes in specimens with high RIPK4 expressions were enriched in focal adhesion, proteoglycans in cancer, central carbon metabolism in cancer, and insulin secretion. Correlation analyses showed that several TICs were positively correlated with RIPK4 expression. The pan-cancer validation results showed that RIPK4 was associated with survival in five tumors. Overall, our findings suggested RIPK4 as a prognostic marker in OC." @default.
- W4221061640 created "2022-04-03" @default.
- W4221061640 creator A5012073557 @default.
- W4221061640 creator A5022489900 @default.
- W4221061640 creator A5029982064 @default.
- W4221061640 creator A5041296808 @default.
- W4221061640 date "2022-03-09" @default.
- W4221061640 modified "2023-09-27" @default.
- W4221061640 title "RIPK4 Is an Immune Regulating-Associated Biomarker for Ovarian Cancer and Possesses Generalization Value in Pan-Cancer" @default.
- W4221061640 cites W1970851801 @default.
- W4221061640 cites W1979178278 @default.
- W4221061640 cites W2052414359 @default.
- W4221061640 cites W2059000970 @default.
- W4221061640 cites W2130549141 @default.
- W4221061640 cites W2134887638 @default.
- W4221061640 cites W2259227992 @default.
- W4221061640 cites W2341048222 @default.
- W4221061640 cites W2529607059 @default.
- W4221061640 cites W2775269156 @default.
- W4221061640 cites W2805509313 @default.
- W4221061640 cites W2891020602 @default.
- W4221061640 cites W2893656853 @default.
- W4221061640 cites W2898813162 @default.
- W4221061640 cites W2906152084 @default.
- W4221061640 cites W2910760721 @default.
- W4221061640 cites W2942092087 @default.
- W4221061640 cites W2943341789 @default.
- W4221061640 cites W2945357020 @default.
- W4221061640 cites W2956024695 @default.
- W4221061640 cites W2966710588 @default.
- W4221061640 cites W2975329111 @default.
- W4221061640 cites W2995862754 @default.
- W4221061640 cites W2999405579 @default.
- W4221061640 cites W3045732541 @default.
- W4221061640 cites W3049120431 @default.
- W4221061640 cites W3099043519 @default.
- W4221061640 cites W3112751811 @default.
- W4221061640 cites W3145919667 @default.
- W4221061640 cites W3184724162 @default.
- W4221061640 cites W4205744506 @default.
- W4221061640 doi "https://doi.org/10.1155/2022/7599098" @default.
- W4221061640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35310605" @default.
- W4221061640 hasPublicationYear "2022" @default.
- W4221061640 type Work @default.
- W4221061640 citedByCount "0" @default.
- W4221061640 crossrefType "journal-article" @default.
- W4221061640 hasAuthorship W4221061640A5012073557 @default.
- W4221061640 hasAuthorship W4221061640A5022489900 @default.
- W4221061640 hasAuthorship W4221061640A5029982064 @default.
- W4221061640 hasAuthorship W4221061640A5041296808 @default.
- W4221061640 hasBestOaLocation W42210616401 @default.
- W4221061640 hasConcept C121608353 @default.
- W4221061640 hasConcept C126322002 @default.
- W4221061640 hasConcept C203014093 @default.
- W4221061640 hasConcept C2780427987 @default.
- W4221061640 hasConcept C2781197716 @default.
- W4221061640 hasConcept C502942594 @default.
- W4221061640 hasConcept C54355233 @default.
- W4221061640 hasConcept C71924100 @default.
- W4221061640 hasConcept C86803240 @default.
- W4221061640 hasConcept C8891405 @default.
- W4221061640 hasConceptScore W4221061640C121608353 @default.
- W4221061640 hasConceptScore W4221061640C126322002 @default.
- W4221061640 hasConceptScore W4221061640C203014093 @default.
- W4221061640 hasConceptScore W4221061640C2780427987 @default.
- W4221061640 hasConceptScore W4221061640C2781197716 @default.
- W4221061640 hasConceptScore W4221061640C502942594 @default.
- W4221061640 hasConceptScore W4221061640C54355233 @default.
- W4221061640 hasConceptScore W4221061640C71924100 @default.
- W4221061640 hasConceptScore W4221061640C86803240 @default.
- W4221061640 hasConceptScore W4221061640C8891405 @default.
- W4221061640 hasLocation W42210616401 @default.
- W4221061640 hasLocation W42210616402 @default.
- W4221061640 hasLocation W42210616403 @default.
- W4221061640 hasLocation W42210616404 @default.
- W4221061640 hasOpenAccess W4221061640 @default.
- W4221061640 hasPrimaryLocation W42210616401 @default.
- W4221061640 hasRelatedWork W2024610616 @default.
- W4221061640 hasRelatedWork W2056385328 @default.
- W4221061640 hasRelatedWork W2064121576 @default.
- W4221061640 hasRelatedWork W2091744362 @default.
- W4221061640 hasRelatedWork W2493518155 @default.
- W4221061640 hasRelatedWork W2577548098 @default.
- W4221061640 hasRelatedWork W3031852375 @default.
- W4221061640 hasRelatedWork W3112940496 @default.
- W4221061640 hasRelatedWork W4226205612 @default.
- W4221061640 hasRelatedWork W4291367166 @default.
- W4221061640 hasVolume "2022" @default.
- W4221061640 isParatext "false" @default.
- W4221061640 isRetracted "false" @default.
- W4221061640 workType "article" @default.