FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225373004> ?p ?o ?g. }

• W4225373004 abstract "Upregulation of vasopressinergic system and increased chemoreflex activity contribute to essential hypertension. Vasopressin (AVP) V1a receptors (V1aRs) were found in the brain stem structures involved in the control of breathing and in the carotid bodies (CBs). It has also been shown that in normotensive rats intravenous (i.v.) and local (intra-carotid, i.a.) AVP administration results in different hemodynamic and respiratory response.We aimed at finding out how systemic (i.v.) and local (i.a.) administration of AVP affects cardiorespiratory system via V1aRs in normo- and hypertensive rats and if V1aRs are expressed in CBs in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats.The study was performed on urethane-anesthetized adult male WKY (n=7) and SHR rats (n=7). Animals were implanted with vascular catheters into femoral vein (i.v. infusions), femoral artery (hemodynamic parameters) and external carotid artery (local infusions), as well as the tracheal tube (respiratory parameters) and subcutaneous ECG electrodes. After obtaining baseline parameters, the arterial chemoreflex was triggered with i.v. administration of potassium cyanide (KCN) (30 μg/100 μL). Bolus of AVP was given i.v. (10 ng/100 μL) and i.a. (5 ng/50 μL). After stabilization of hemodynamic and respiratory parameters, V1a receptor was blocked by administration of V1aR antagonist (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin; 5 μg/100 μL) and AVP and KCN infusions were repeated. After measurements, carotid bodies (CBs) were collected and immunostained for V1aRs and visualized with confocal microscopy.Resting mean arterial blood pressure (MABP), heart rate (HR) and minute ventilation (MV) were significantly higher in SHR rats than in WKY control. In both groups hemodynamic and respiratory response to pharmacological trigger of the reflex occurred, however increase in MABP and MV were significantly greater in SHR than in WKY rats. Intravenous AVP administration caused an increase in MABP, but ventilatory inhibition only in SHR rats. Intra-arterial AVP infusion caused a modest increase in MABP in both groups, but inhibition of ventilation only in SHR rats. Blockade of V1aR abolished the effects of both systemic and local AVP administration. Furthermore, V1aR antagonist decreased the pressor component of the chemoreflex, however it did not influence ventilatory response. Immunostaining revealed V1aRs in CBs in both groups.Our findings show that enhanced cardiorespiratory responses to activation of arterial chemoreflex and augmented pressor and ventilatory effects of systemic and local administrations of AVP are present in hypertensive rats and depend on V1aRs. Presence of V1aRs in CBs suggests that AVP may control cardiorespiratory system via arterial chemoreceptors." @default.
• W4225373004 created "2022-05-05" @default.
• W4225373004 creator A5006964206 @default.
• W4225373004 creator A5043538864 @default.
• W4225373004 creator A5069907985 @default.
• W4225373004 date "2022-05-01" @default.
• W4225373004 modified "2023-09-27" @default.
• W4225373004 title "Systemic and local administration of vasopressin differently affect hemodynamic and respiratory parameters in normotensive and hypertensive rats" @default.
• W4225373004 doi "https://doi.org/10.1096/fasebj.2022.36.s1.r4451" @default.
• W4225373004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35556071" @default.
• W4225373004 hasPublicationYear "2022" @default.
• W4225373004 type Work @default.
• W4225373004 citedByCount "0" @default.
• W4225373004 crossrefType "journal-article" @default.
• W4225373004 hasAuthorship W4225373004A5006964206 @default.
• W4225373004 hasAuthorship W4225373004A5043538864 @default.
• W4225373004 hasAuthorship W4225373004A5069907985 @default.
• W4225373004 hasConcept C126322002 @default.
• W4225373004 hasConcept C134018914 @default.
• W4225373004 hasConcept C178853913 @default.
• W4225373004 hasConcept C2776370428 @default.
• W4225373004 hasConcept C2776452961 @default.
• W4225373004 hasConcept C2777953023 @default.
• W4225373004 hasConcept C2779723990 @default.
• W4225373004 hasConcept C42219234 @default.
• W4225373004 hasConcept C534529494 @default.
• W4225373004 hasConcept C71924100 @default.
• W4225373004 hasConcept C84393581 @default.
• W4225373004 hasConceptScore W4225373004C126322002 @default.
• W4225373004 hasConceptScore W4225373004C134018914 @default.
• W4225373004 hasConceptScore W4225373004C178853913 @default.
• W4225373004 hasConceptScore W4225373004C2776370428 @default.
• W4225373004 hasConceptScore W4225373004C2776452961 @default.
• W4225373004 hasConceptScore W4225373004C2777953023 @default.
• W4225373004 hasConceptScore W4225373004C2779723990 @default.
• W4225373004 hasConceptScore W4225373004C42219234 @default.
• W4225373004 hasConceptScore W4225373004C534529494 @default.
• W4225373004 hasConceptScore W4225373004C71924100 @default.
• W4225373004 hasConceptScore W4225373004C84393581 @default.
• W4225373004 hasIssue "S1" @default.
• W4225373004 hasLocation W42253730041 @default.
• W4225373004 hasLocation W42253730042 @default.
• W4225373004 hasOpenAccess W4225373004 @default.
• W4225373004 hasPrimaryLocation W42253730041 @default.
• W4225373004 hasRelatedWork W2022651435 @default.
• W4225373004 hasRelatedWork W2037868453 @default.
• W4225373004 hasRelatedWork W2080171008 @default.
• W4225373004 hasRelatedWork W2195513968 @default.
• W4225373004 hasRelatedWork W2285354716 @default.
• W4225373004 hasRelatedWork W2392249173 @default.
• W4225373004 hasRelatedWork W2582971951 @default.
• W4225373004 hasRelatedWork W2781698216 @default.
• W4225373004 hasRelatedWork W2977523330 @default.
• W4225373004 hasRelatedWork W2979617965 @default.
• W4225373004 hasVolume "36" @default.
• W4225373004 isParatext "false" @default.
• W4225373004 isRetracted "false" @default.
• W4225373004 workType "article" @default.