Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229034749> ?p ?o ?g. }
- W4229034749 endingPage "914" @default.
- W4229034749 startingPage "914" @default.
- W4229034749 abstract "This study aimed to evaluate whether (-)-epigallocatechin-3-gallate (EGCG) alleviates hepatic responses to lipopolysaccharide (LPS)-induced inflammation and oxidation. Isolated bovine hepatocytes and BALB/c mice were used for LPS challenge and EGCG pretreatment experiments in vitro and in vivo. LPS-challenged (6 μg/mL) hepatocytes exhibited increased levels of NF-κB (p65 and IκBα) and MAPK (p38, ERK, JNK) phosphorylation as well as increased binding activity of p65 to target pro-inflammatory gene promoters, and these effects were suppressed by pretreatment with 50 μM EGCG. Moreover, the reduction in Nrf2 signaling and antioxidant enzyme activities induced by LPS stimulation were reversed upon EGCG treatment. In vivo experiments demonstrated the protective role of EGCG in response to GalN/LPS-induced mortality and oxidative damage. Together, our results suggest that EGCG is hepatoprotective via inhibition of MAPK/NF-κB signaling and activation of the Nrf2 cascade. This information might help design strategies for counteracting hepatitis in ruminants and monogastric animals." @default.
- W4229034749 created "2022-05-08" @default.
- W4229034749 creator A5015743959 @default.
- W4229034749 creator A5017172191 @default.
- W4229034749 creator A5018535449 @default.
- W4229034749 creator A5064312014 @default.
- W4229034749 creator A5085251345 @default.
- W4229034749 creator A5090893029 @default.
- W4229034749 date "2022-05-06" @default.
- W4229034749 modified "2023-10-03" @default.
- W4229034749 title "The Inhibition of LPS-Induced Oxidative Stress and Inflammatory Responses Is Associated with the Protective Effect of (-)-Epigallocatechin-3-Gallate on Bovine Hepatocytes and Murine Liver" @default.
- W4229034749 cites W1573635219 @default.
- W4229034749 cites W1630263658 @default.
- W4229034749 cites W1870638847 @default.
- W4229034749 cites W1971061762 @default.
- W4229034749 cites W1975022233 @default.
- W4229034749 cites W1980870391 @default.
- W4229034749 cites W1991131105 @default.
- W4229034749 cites W2014830013 @default.
- W4229034749 cites W2021953758 @default.
- W4229034749 cites W2026253315 @default.
- W4229034749 cites W2037820438 @default.
- W4229034749 cites W2041653662 @default.
- W4229034749 cites W2044734450 @default.
- W4229034749 cites W2053977755 @default.
- W4229034749 cites W2055612816 @default.
- W4229034749 cites W2060610804 @default.
- W4229034749 cites W2061795360 @default.
- W4229034749 cites W2065802636 @default.
- W4229034749 cites W2072754141 @default.
- W4229034749 cites W2091931063 @default.
- W4229034749 cites W2093145018 @default.
- W4229034749 cites W2106860587 @default.
- W4229034749 cites W2108024349 @default.
- W4229034749 cites W2108244474 @default.
- W4229034749 cites W2124357835 @default.
- W4229034749 cites W2137744856 @default.
- W4229034749 cites W2150035464 @default.
- W4229034749 cites W2157034748 @default.
- W4229034749 cites W2158627137 @default.
- W4229034749 cites W2168047437 @default.
- W4229034749 cites W2305329969 @default.
- W4229034749 cites W2398729939 @default.
- W4229034749 cites W2523659868 @default.
- W4229034749 cites W2551383257 @default.
- W4229034749 cites W2652430319 @default.
- W4229034749 cites W2738930982 @default.
- W4229034749 cites W2765732544 @default.
- W4229034749 cites W2765913064 @default.
- W4229034749 cites W2778380307 @default.
- W4229034749 cites W2802324910 @default.
- W4229034749 cites W2806524634 @default.
- W4229034749 cites W2887893321 @default.
- W4229034749 cites W2892476289 @default.
- W4229034749 cites W2905663314 @default.
- W4229034749 cites W2905933565 @default.
- W4229034749 cites W2915298192 @default.
- W4229034749 cites W2947997528 @default.
- W4229034749 cites W2989061032 @default.
- W4229034749 cites W3010283440 @default.
- W4229034749 cites W3113184829 @default.
- W4229034749 cites W3113578990 @default.
- W4229034749 cites W3141205210 @default.
- W4229034749 cites W3144650691 @default.
- W4229034749 cites W3212823651 @default.
- W4229034749 cites W4214568954 @default.
- W4229034749 cites W612602829 @default.
- W4229034749 doi "https://doi.org/10.3390/antiox11050914" @default.
- W4229034749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35624778" @default.
- W4229034749 hasPublicationYear "2022" @default.
- W4229034749 type Work @default.
- W4229034749 citedByCount "6" @default.
- W4229034749 countsByYear W42290347492022 @default.
- W4229034749 countsByYear W42290347492023 @default.
- W4229034749 crossrefType "journal-article" @default.
- W4229034749 hasAuthorship W4229034749A5015743959 @default.
- W4229034749 hasAuthorship W4229034749A5017172191 @default.
- W4229034749 hasAuthorship W4229034749A5018535449 @default.
- W4229034749 hasAuthorship W4229034749A5064312014 @default.
- W4229034749 hasAuthorship W4229034749A5085251345 @default.
- W4229034749 hasAuthorship W4229034749A5090893029 @default.
- W4229034749 hasBestOaLocation W42290347491 @default.
- W4229034749 hasConcept C134018914 @default.
- W4229034749 hasConcept C150903083 @default.
- W4229034749 hasConcept C185592680 @default.
- W4229034749 hasConcept C203014093 @default.
- W4229034749 hasConcept C207001950 @default.
- W4229034749 hasConcept C24998067 @default.
- W4229034749 hasConcept C2776151105 @default.
- W4229034749 hasConcept C2776914184 @default.
- W4229034749 hasConcept C2777192995 @default.
- W4229034749 hasConcept C2777730290 @default.
- W4229034749 hasConcept C2778004101 @default.
- W4229034749 hasConcept C2778754761 @default.
- W4229034749 hasConcept C51551487 @default.
- W4229034749 hasConcept C55493867 @default.
- W4229034749 hasConcept C57074206 @default.
- W4229034749 hasConcept C62478195 @default.