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• W4229042097 abstract "Significance Glutamine is the most abundant amino acid in human plasma, although it is challenging to determine glutamine’s metabolic fate noninvasively. In this work, we utilize established chemical methods to develop a platform for imaging glutamine metabolism using hyperpolarized magnetic resonance imaging. Using this strategy, we are able to spatially measure glutaminolysis in vivo as well as develop a biomarker for the inhibition of glutaminase. Combining this biomarker with isotope tracing metabolomics connects this inhibition to reduced glutamine contribution to the tricarboxylic acid cycle. This provides an approach for future imaging of glutamine metabolism in humans." @default.
• W4229042097 created "2022-05-08" @default.
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• W4229042097 date "2022-05-05" @default.
• W4229042097 modified "2023-10-05" @default.
• W4229042097 title "Hyperpolarized [5- ¹³ C,4,4- ² H ₂ ,5- ¹⁵ N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine" @default.
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• W4229042097 doi "https://doi.org/10.1073/pnas.2120595119" @default.
• W4229042097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35512101" @default.
• W4229042097 hasPublicationYear "2022" @default.
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