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- W4230244726 abstract "Insulin receptor (IR) belongs to the receptor tyrosine kinase family. In humans, complete lack of IRs due to mutations of the insulin receptor gene, results in severe growth retardation and insulin-resistant diabetes. This chapter presents a study in which mice homozygous for a null allele of the insulin receptor gene were born at term with normal intrauterine growth and development. Within hours of birth, however, homozygous null mice developed severe hyperglycemia and hyperketonemia, and died as the result of diabetic ketoacidosis in 48–72 hours. These data are consistent with a model in which the insulin receptor functions primarily to mediate the metabolic actions of insulin. This model is important for the evaluation of insulin action vis-à-vis the action of other growth factors of the insulin family, such as IGF-I and IGF-II, as well as the role of signaling molecules such as IRS-1 in mediating the metabolic actions of insulin." @default.
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- W4230244726 date "1998-01-01" @default.
- W4230244726 modified "2023-09-27" @default.
- W4230244726 title "IR" @default.
- W4230244726 doi "https://doi.org/10.1016/b978-012466044-1/50354-9" @default.
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