FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4238482110> ?p ?o ?g. }

• W4238482110 endingPage "166" @default.
• W4238482110 startingPage "141" @default.
• W4238482110 abstract "JIGNESHKUMAR PATEL, RAVI R. PATHAK, and SHIRAZ MUJTABAINTRODUCTIONDNA methylation and lysine modifications comprise major epigenetic processes on chromatin, which alter nucleosomal architecture leading to gene activation or repression [1-3]. Dynamic post-translational modifications (PTMs) occurring in the proximity of a gene promoter are one of the hallmarks of epigenetic regulation of gene expression [4]. Although an individual lysine residue may undergo mutually exclusive multiple PTMs, including acetylation, methylation, neddylation, ubiquitination and sumoylation, multiple lysines of a single protein can undergo diverse modifications [5,6]. Functionally, these site-specific PTMs, which are established during transcriptional programming, impart flexibility to regulate cellular processes in response to diverse physiological and external stimuli. PTMs impact functional capabilities of a protein, thus validating the notion that biological complexities are not restricted only by the number of genes [7]. To elucidate the functional consequences of a single PTM or combinatorial PTMs occurring on chromatin, the histone code hypothesis proposes to integrate the gene regulatory ability of a site-specific histone modification within its biological context [8,9]. In quintessence, a site-specific PTM serves as a mark to recruit a chromatin-associated protein complex(es) that participates in controlling gene activity, thereby, regulating cell fate decisions [10]. For instance, within chromatin, depending on the site and degree of the modification, lysine methylation can cause either gene activation or repression; lysine acetylation on histonesis associated with chromatin relaxation contributing to gene activation; and the biochemical outcome of lysine ubiquitination or sumoylation is dynamic turnover of proteins. In addition, although the role of methylation in modulating non-histone proteins, including transcription factor activity, is only beginning to be understood, acetylation of transcription factors can affect their DNA-binding ability, stability, nuclear translocation and capacity to activate target genes [7,11]." @default.
• W4238482110 created "2022-05-12" @default.
• W4238482110 date "2013-11-25" @default.
• W4238482110 modified "2023-10-14" @default.
• W4238482110 title "The Biology of Lysine Acetylation Integrates Transcriptional Programming and Metabolism" @default.
• W4238482110 cites W139117875 @default.
• W4238482110 cites W1493702629 @default.
• W4238482110 cites W1504229479 @default.
• W4238482110 cites W1611419331 @default.
• W4238482110 cites W1786491527 @default.
• W4238482110 cites W1858393860 @default.
• W4238482110 cites W1878626643 @default.
• W4238482110 cites W190848849 @default.
• W4238482110 cites W1926287352 @default.
• W4238482110 cites W193388854 @default.
• W4238482110 cites W1964943248 @default.
• W4238482110 cites W1965893340 @default.
• W4238482110 cites W1966010937 @default.
• W4238482110 cites W1967194777 @default.
• W4238482110 cites W1967703437 @default.
• W4238482110 cites W1968008181 @default.
• W4238482110 cites W1970108031 @default.
• W4238482110 cites W1972602074 @default.
• W4238482110 cites W1972664178 @default.
• W4238482110 cites W1974561525 @default.
• W4238482110 cites W1974999735 @default.
• W4238482110 cites W1976875491 @default.
• W4238482110 cites W1984214021 @default.
• W4238482110 cites W1984807040 @default.
• W4238482110 cites W1986095118 @default.
• W4238482110 cites W1986885172 @default.
• W4238482110 cites W1986903527 @default.
• W4238482110 cites W1988105611 @default.
• W4238482110 cites W1992638032 @default.
• W4238482110 cites W1994438989 @default.
• W4238482110 cites W1996874832 @default.
• W4238482110 cites W1997485672 @default.
• W4238482110 cites W1997981312 @default.
• W4238482110 cites W1998589450 @default.
• W4238482110 cites W1998767538 @default.
• W4238482110 cites W2000496185 @default.
• W4238482110 cites W2002995168 @default.
• W4238482110 cites W2004487596 @default.
• W4238482110 cites W2006169630 @default.
• W4238482110 cites W2009263545 @default.
• W4238482110 cites W2009871251 @default.
• W4238482110 cites W2010060180 @default.
• W4238482110 cites W2010978319 @default.
• W4238482110 cites W2013195055 @default.
• W4238482110 cites W2017435031 @default.
• W4238482110 cites W2022354436 @default.
• W4238482110 cites W2023480399 @default.
• W4238482110 cites W2023795307 @default.
• W4238482110 cites W2026472364 @default.
• W4238482110 cites W2027873015 @default.
• W4238482110 cites W2028370869 @default.
• W4238482110 cites W2028450008 @default.
• W4238482110 cites W2029914169 @default.
• W4238482110 cites W2031724786 @default.
• W4238482110 cites W2034161080 @default.
• W4238482110 cites W2035282066 @default.
• W4238482110 cites W2036224487 @default.
• W4238482110 cites W2037548653 @default.
• W4238482110 cites W2038287336 @default.
• W4238482110 cites W2038586807 @default.
• W4238482110 cites W2042217178 @default.
• W4238482110 cites W2042857642 @default.
• W4238482110 cites W2044640853 @default.
• W4238482110 cites W2046314136 @default.
• W4238482110 cites W2047184358 @default.
• W4238482110 cites W2047649751 @default.
• W4238482110 cites W2048084024 @default.
• W4238482110 cites W2048619491 @default.
• W4238482110 cites W2048960694 @default.
• W4238482110 cites W2049062557 @default.
• W4238482110 cites W2055402151 @default.
• W4238482110 cites W2056026273 @default.
• W4238482110 cites W2058484411 @default.
• W4238482110 cites W2060037353 @default.
• W4238482110 cites W2060228790 @default.
• W4238482110 cites W2060275730 @default.
• W4238482110 cites W2060512760 @default.
• W4238482110 cites W2061911257 @default.
• W4238482110 cites W2062427797 @default.
• W4238482110 cites W2062500929 @default.
• W4238482110 cites W2067606868 @default.
• W4238482110 cites W2068707753 @default.
• W4238482110 cites W2068784971 @default.
• W4238482110 cites W2069009920 @default.
• W4238482110 cites W2070777085 @default.
• W4238482110 cites W2072269334 @default.
• W4238482110 cites W2072886988 @default.
• W4238482110 cites W2075163167 @default.
• W4238482110 cites W2076778057 @default.
• W4238482110 cites W2076808589 @default.
• W4238482110 cites W2080323656 @default.
• W4238482110 cites W2081261283 @default.
• W4238482110 cites W2081279521 @default.

• next