Matches in SemOpenAlex for { <https://semopenalex.org/work/W4240485957> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4240485957 abstract "The investigation and observations made for the M2TM, excess aminoadamantane ligands in DMPC were made using the simpler version of biophysical methods including SDC, SAXS and WAXS, MD simulations and ssNMR. 1H, 31P ssNMR and MD simulations, showed that M2TM in apo form or drug-bound form span the membrane interacting strongly with lipid acyl chain tails and the phosphate groups of the polar head surface. The MD simulations showed that the drugs anchor through their ammonium group with the lipid phosphate and occasionally with M2TM asparagine-44 carboxylate groups. The 13C ssNMR experiments allow the inspection of excess drug molecules and the assessment of its impact on the lipid head-group region. At low peptide concentrations of influenza A M2TM tetramer in DPMC bilayer, two lipid domains were observed that likely correspond to the M2TM boundary lipids and the bulk-like lipids. At high peptide concentrations, one domain was identified which constitute essentially all of the lipids which behave as boundary. This effect is likely due, according to the MD simulations, to the preference of AK13 to locate in closer vicinity to M2TM compared to Amt as well as the stronger ionic interactions of Amt primary ammonium group with phosphate groups, compared with the secondary buried ammonium group in AK13.<br>" @default.
- W4240485957 created "2022-05-12" @default.
- W4240485957 creator A5007170413 @default.
- W4240485957 creator A5015546229 @default.
- W4240485957 creator A5026225593 @default.
- W4240485957 creator A5026644021 @default.
- W4240485957 creator A5028583687 @default.
- W4240485957 creator A5033530074 @default.
- W4240485957 creator A5037950651 @default.
- W4240485957 creator A5040161019 @default.
- W4240485957 creator A5054696287 @default.
- W4240485957 creator A5060828063 @default.
- W4240485957 creator A5063216069 @default.
- W4240485957 creator A5076907491 @default.
- W4240485957 creator A5081215916 @default.
- W4240485957 creator A5088598044 @default.
- W4240485957 date "2019-07-22" @default.
- W4240485957 modified "2023-09-24" @default.
- W4240485957 title "Influenza A M2 Spans the Membrane Bilayer, Perturbs its Organization and Differentiates the Effect of Amantadine and Spiro[pyrrolidine-2,2'-adamantane] AK13 on Lipids" @default.
- W4240485957 doi "https://doi.org/10.26434/chemrxiv.8969678" @default.
- W4240485957 hasPublicationYear "2019" @default.
- W4240485957 type Work @default.
- W4240485957 citedByCount "0" @default.
- W4240485957 crossrefType "posted-content" @default.
- W4240485957 hasAuthorship W4240485957A5007170413 @default.
- W4240485957 hasAuthorship W4240485957A5015546229 @default.
- W4240485957 hasAuthorship W4240485957A5026225593 @default.
- W4240485957 hasAuthorship W4240485957A5026644021 @default.
- W4240485957 hasAuthorship W4240485957A5028583687 @default.
- W4240485957 hasAuthorship W4240485957A5033530074 @default.
- W4240485957 hasAuthorship W4240485957A5037950651 @default.
- W4240485957 hasAuthorship W4240485957A5040161019 @default.
- W4240485957 hasAuthorship W4240485957A5054696287 @default.
- W4240485957 hasAuthorship W4240485957A5060828063 @default.
- W4240485957 hasAuthorship W4240485957A5063216069 @default.
- W4240485957 hasAuthorship W4240485957A5076907491 @default.
- W4240485957 hasAuthorship W4240485957A5081215916 @default.
- W4240485957 hasAuthorship W4240485957A5088598044 @default.
- W4240485957 hasBestOaLocation W42404859571 @default.
- W4240485957 hasConcept C147597530 @default.
- W4240485957 hasConcept C178790620 @default.
- W4240485957 hasConcept C181199279 @default.
- W4240485957 hasConcept C185592680 @default.
- W4240485957 hasConcept C192157962 @default.
- W4240485957 hasConcept C2778074193 @default.
- W4240485957 hasConcept C2778886173 @default.
- W4240485957 hasConcept C2779556047 @default.
- W4240485957 hasConcept C32909587 @default.
- W4240485957 hasConcept C39944091 @default.
- W4240485957 hasConcept C41625074 @default.
- W4240485957 hasConcept C55493867 @default.
- W4240485957 hasConcept C59593255 @default.
- W4240485957 hasConcept C71240020 @default.
- W4240485957 hasConcept C8010536 @default.
- W4240485957 hasConceptScore W4240485957C147597530 @default.
- W4240485957 hasConceptScore W4240485957C178790620 @default.
- W4240485957 hasConceptScore W4240485957C181199279 @default.
- W4240485957 hasConceptScore W4240485957C185592680 @default.
- W4240485957 hasConceptScore W4240485957C192157962 @default.
- W4240485957 hasConceptScore W4240485957C2778074193 @default.
- W4240485957 hasConceptScore W4240485957C2778886173 @default.
- W4240485957 hasConceptScore W4240485957C2779556047 @default.
- W4240485957 hasConceptScore W4240485957C32909587 @default.
- W4240485957 hasConceptScore W4240485957C39944091 @default.
- W4240485957 hasConceptScore W4240485957C41625074 @default.
- W4240485957 hasConceptScore W4240485957C55493867 @default.
- W4240485957 hasConceptScore W4240485957C59593255 @default.
- W4240485957 hasConceptScore W4240485957C71240020 @default.
- W4240485957 hasConceptScore W4240485957C8010536 @default.
- W4240485957 hasLocation W42404859571 @default.
- W4240485957 hasOpenAccess W4240485957 @default.
- W4240485957 hasPrimaryLocation W42404859571 @default.
- W4240485957 hasRelatedWork W17541000 @default.
- W4240485957 hasRelatedWork W2265568 @default.
- W4240485957 hasRelatedWork W22868014 @default.
- W4240485957 hasRelatedWork W2942908 @default.
- W4240485957 hasRelatedWork W3045790 @default.
- W4240485957 hasRelatedWork W33578133 @default.
- W4240485957 hasRelatedWork W3370045 @default.
- W4240485957 hasRelatedWork W37851903 @default.
- W4240485957 hasRelatedWork W397716 @default.
- W4240485957 hasRelatedWork W5228315 @default.
- W4240485957 isParatext "false" @default.
- W4240485957 isRetracted "false" @default.
- W4240485957 workType "article" @default.