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• W4248426685 abstract "Cosmeceutical preparations are rapidly proliferating and becoming increasingly sophisticated. The potential value of these formulations for skin health is tremendous; yet, both the consumer and the physician are challenged when evaluating their benefits. Can an arbutin and kojic acid moisturizer aid in skin lightening when combined with a prescription 4% hydroquinone cream? Is it possible for a bisabolol cream to reduce facial redness when used after a prescription topical antibiotic in the treatment of rosacea? Will a retinol moisturizer enhance the antiaging results of prescription tretinoin? These are important questions for the dermatologist to answer, as patients are willing to apply multiple products as long as they provide an additive benefit. Many prescription dermatologics fall short of patient expectations, opening the way for the use of cosmeceuticals to enhance the outcome. However, the physician has some guarantee that the pharmaceuticals are at least moderately effective or the Food and Drug Administration or other international regulatory authority for drug status would not have approved them. Safety and efficacy are the two most important parameters for drug approval, but this is not the case for cosmeceuticals. There is no equivalent approval body for cosmeceuticals in the United States or the European Union, but the time has come. Cosmeceuticals are a large part of dermatology around the world. Dermatologists need to know which cosmeceuticals provide a medical benefit and which fall into the category of snake oil. I would propose that dermatology take the lead in creating a body of experts to credential cosmeceuticals. The role of this body would be to evaluate manufacturer data to determine if the product delivers on claims. Certainly, cosmeceuticals cannot be studied with the same rigidity as drugs, but the need to meet basic criteria remains. For example, manufacturers could submit their in vitro and in vivo studies. The adequacy of in vitro models could be assessed for their proper application. Better models for evaluation could be suggested. In vivo studies could be examined for an adequate number of research subjects and the proper application of statistical methods. A review of the research methods would be a huge step forward in improving the science of cosmeceuticals. Once a product manufacturer presented studies that met some minimum requirement, as established by the review committee, it could receive a seal of approval. This seal would not guarantee efficacy, since this may not be possible at present in the cosmeceutical realm, but it could establish safety and mandate minimal testing requirements. Physicians and consumers could use the seal as an indication that the cosmeceutical was of more than snake oil value. Perhaps as the sophistication of cosmeceutical technology advanced, the seal could also advance and add new evaluation parameters. This seal program could help dermatologists decide which cosmeceuticals to recommend as adjunct treatments to prescription therapy. It would encourage research in the area and raise the standards for performance. Without some type of product evaluation, cosmeceuticals will remain in the quasi-science realm. Japan created a separate product category for cosmeceuticals, which has propelled their research ahead globally. While this idea may seem unworkable, it is the first step in the necessary process of credentialing cosmeceuticals." @default.
• W4248426685 created "2022-05-12" @default.
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• W4248426685 date "2008-12-01" @default.
• W4248426685 modified "2023-09-26" @default.
• W4248426685 title "Credentialing cosmeceuticals" @default.
• W4248426685 doi "https://doi.org/10.1111/j.1473-2165.2008.00400.x" @default.
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