FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249443317> ?p ?o ?g. }

• W4249443317 endingPage "310" @default.
• W4249443317 startingPage "304" @default.
• W4249443317 abstract "Percutaneous transluminal angioplasty (PTA), although not the traditional therapy, seems to be a safe alternative for patients with critical limb ischemia who are believed to be unsuitable candidates for open surgery. However, the efficacy of PTA in this setting has not been analyzed. The purpose of this study was to compare the outcomes of PTA for limb salvage with outcomes of major limb amputation in physiologically impaired patients believed to be unsuitable for open surgery.From a prospective vascular registry, 314 patients (183 underwent amputation, and 131 underwent complex PTA for limb salvage) were identified as physiologically impaired or unsuitable for open surgery. This was defined as having at least one of the following: functional impairment (homebound ambulatory or transfer only), mental impairment (dementia), or medical impairment (two of the following: end-stage renal disease, coronary artery disease, and chronic obstructive pulmonary disease). Patients undergoing PTA were compared with patients undergoing amputation by examining the outcome parameters of survival, maintenance of ambulation, and maintenance of independent living status. Parameters were assessed by using Kaplan-Meier life-table curves (log-rank test and 95% confidence intervals [CIs]) and hazard ratios (HRs) from the Cox model.PTA resulted in a 12-month limb salvage rate of 63%. Thirty-day mortality was 4.4% for the amputation group and 3.8% for the PTA group. After adjustment for age, race, diabetes, prior vascular procedure, dementia, and baseline functional status, PTA patients had significantly lower rates of ambulation failure (HR, 0.44; P = .0002) and loss of independence (HR, 0.53; P = .025) but had significantly higher mortality (HR, 1.62; P = .006) than amputees. However, when life tables were examined, the maintenance of ambulation advantage lasted only 12 months (PTA, 68.6%; 95% CI, 59.6%-77.7%; amputation, 48%; 95% CI, 40.4%-55.5%) and was not statistically significant at 2 years (62.2% [95% CI, 48.8%-71.5%] and 44% [95% CI, 35.8%-52.2%], respectively). Maintenance of independent living status advantage lasted only 3 months, with no statistically significant difference at 2 years (PTA, 60.5%; 95% CI, 45.4%-75.6%; amputation, 52.6%; 95% CI, 40.4%-64.9%). Although mortality was high in both cohorts, patients who underwent amputation had a survival advantage for all time intervals examined (at 2 years: PTA, 29%; 95% CI, 19.9%-38.1%; amputation, 48.1%; 95% CI, 39.2%-56.9%).Patients who present with critical limb ischemia and physiologic impairments that preclude open surgery seem to have comorbidities that blunt any functional advantage achieved after PTA for limb salvage. PTA in this setting affords very little benefit compared with amputation alone." @default.
• W4249443317 created "2022-05-12" @default.
• W4249443317 creator A5000351871 @default.
• W4249443317 creator A5014569116 @default.
• W4249443317 creator A5022900234 @default.
• W4249443317 creator A5041744887 @default.
• W4249443317 creator A5051068027 @default.
• W4249443317 creator A5065863301 @default.
• W4249443317 date "2007-02-01" @default.
• W4249443317 modified "2023-09-28" @default.
• W4249443317 title "A comparison of percutaneous transluminal angioplasty versus amputation for critical limb ischemia in patients unsuitable for open surgery" @default.
• W4249443317 cites W1783012227 @default.
• W4249443317 cites W1969223174 @default.
• W4249443317 cites W1970751145 @default.
• W4249443317 cites W1983503106 @default.
• W4249443317 cites W2016542369 @default.
• W4249443317 cites W2019222720 @default.
• W4249443317 cites W2042796845 @default.
• W4249443317 cites W2066759512 @default.
• W4249443317 cites W2081256349 @default.
• W4249443317 cites W2088166517 @default.
• W4249443317 cites W2108514377 @default.
• W4249443317 cites W2122027070 @default.
• W4249443317 cites W2123006104 @default.
• W4249443317 cites W2139258065 @default.
• W4249443317 cites W2146240140 @default.
• W4249443317 doi "https://doi.org/10.1016/j.jvs.2006.09.038" @default.
• W4249443317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17264008" @default.
• W4249443317 hasPublicationYear "2007" @default.
• W4249443317 type Work @default.
• W4249443317 citedByCount "42" @default.
• W4249443317 countsByYear W42494433172012 @default.
• W4249443317 countsByYear W42494433172013 @default.
• W4249443317 countsByYear W42494433172014 @default.
• W4249443317 countsByYear W42494433172015 @default.
• W4249443317 countsByYear W42494433172016 @default.
• W4249443317 countsByYear W42494433172017 @default.
• W4249443317 countsByYear W42494433172021 @default.
• W4249443317 countsByYear W42494433172022 @default.
• W4249443317 countsByYear W42494433172023 @default.
• W4249443317 crossrefType "journal-article" @default.
• W4249443317 hasAuthorship W4249443317A5000351871 @default.
• W4249443317 hasAuthorship W4249443317A5014569116 @default.
• W4249443317 hasAuthorship W4249443317A5022900234 @default.
• W4249443317 hasAuthorship W4249443317A5041744887 @default.
• W4249443317 hasAuthorship W4249443317A5051068027 @default.
• W4249443317 hasAuthorship W4249443317A5065863301 @default.
• W4249443317 hasBestOaLocation W42494433171 @default.
• W4249443317 hasConcept C126322002 @default.
• W4249443317 hasConcept C141071460 @default.
• W4249443317 hasConcept C207103383 @default.
• W4249443317 hasConcept C2776204877 @default.
• W4249443317 hasConcept C2778213512 @default.
• W4249443317 hasConcept C2779464278 @default.
• W4249443317 hasConcept C2780326628 @default.
• W4249443317 hasConcept C2780813298 @default.
• W4249443317 hasConcept C35785553 @default.
• W4249443317 hasConcept C44249647 @default.
• W4249443317 hasConcept C500558357 @default.
• W4249443317 hasConcept C71924100 @default.
• W4249443317 hasConceptScore W4249443317C126322002 @default.
• W4249443317 hasConceptScore W4249443317C141071460 @default.
• W4249443317 hasConceptScore W4249443317C207103383 @default.
• W4249443317 hasConceptScore W4249443317C2776204877 @default.
• W4249443317 hasConceptScore W4249443317C2778213512 @default.
• W4249443317 hasConceptScore W4249443317C2779464278 @default.
• W4249443317 hasConceptScore W4249443317C2780326628 @default.
• W4249443317 hasConceptScore W4249443317C2780813298 @default.
• W4249443317 hasConceptScore W4249443317C35785553 @default.
• W4249443317 hasConceptScore W4249443317C44249647 @default.
• W4249443317 hasConceptScore W4249443317C500558357 @default.
• W4249443317 hasConceptScore W4249443317C71924100 @default.
• W4249443317 hasIssue "2" @default.
• W4249443317 hasLocation W42494433171 @default.
• W4249443317 hasLocation W42494433172 @default.
• W4249443317 hasOpenAccess W4249443317 @default.
• W4249443317 hasPrimaryLocation W42494433171 @default.
• W4249443317 hasRelatedWork W1972702180 @default.
• W4249443317 hasRelatedWork W1973268331 @default.
• W4249443317 hasRelatedWork W1978164495 @default.
• W4249443317 hasRelatedWork W1996361423 @default.
• W4249443317 hasRelatedWork W2073722551 @default.
• W4249443317 hasRelatedWork W2086010554 @default.
• W4249443317 hasRelatedWork W2117378160 @default.
• W4249443317 hasRelatedWork W2794495824 @default.
• W4249443317 hasRelatedWork W4313252087 @default.
• W4249443317 hasRelatedWork W2461326802 @default.
• W4249443317 hasVolume "45" @default.
• W4249443317 isParatext "false" @default.
• W4249443317 isRetracted "false" @default.
• W4249443317 workType "article" @default.