Matches in SemOpenAlex for { <https://semopenalex.org/work/W4250170566> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4250170566 endingPage "S30" @default.
- W4250170566 startingPage "S30" @default.
- W4250170566 abstract "Alzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase Aβ production. Here, we demonstrate that CatB actually reduces levels of Aβ peptides, especially the aggregation-prone species Aβ1-42, through proteolytic cleavage. Genetic inactivation of CatB in mice with neuronal expression of familial AD-mutant human amyloid precursor protein (hAPP) increased the relative abundance of Aβ1-42, worsening plaque deposition and other AD-related pathologies. Lentivirus-mediated expression of CatB in aged hAPP mice reduced preexisting amyloid deposits, even thioflavin S-positive plaques. Under cell-free conditions, CatB effectively cleaved Aβ1-42, generating C-terminally truncated Aβ peptides that are less amyloidogenic. Thus, CatB likely fulfills antiamyloidogenic and neuroprotective functions. Insufficient CatB activity might promote AD; increasing CatB activity could counteract the neuropathology of this disease." @default.
- W4250170566 created "2022-05-12" @default.
- W4250170566 date "1994-01-01" @default.
- W4250170566 modified "2023-09-26" @default.
- W4250170566 title "Cellular and transgenic mouse models to study senile plaque and β amyloid specific amyloidosis" @default.
- W4250170566 doi "https://doi.org/10.1016/0197-4580(94)92577-1" @default.
- W4250170566 hasPublicationYear "1994" @default.
- W4250170566 type Work @default.
- W4250170566 citedByCount "0" @default.
- W4250170566 crossrefType "journal-article" @default.
- W4250170566 hasConcept C102230213 @default.
- W4250170566 hasConcept C104317684 @default.
- W4250170566 hasConcept C141035611 @default.
- W4250170566 hasConcept C142724271 @default.
- W4250170566 hasConcept C151484617 @default.
- W4250170566 hasConcept C153911025 @default.
- W4250170566 hasConcept C167844969 @default.
- W4250170566 hasConcept C177907266 @default.
- W4250170566 hasConcept C181199279 @default.
- W4250170566 hasConcept C185592680 @default.
- W4250170566 hasConcept C25498285 @default.
- W4250170566 hasConcept C2777633098 @default.
- W4250170566 hasConcept C2778896982 @default.
- W4250170566 hasConcept C2779134260 @default.
- W4250170566 hasConcept C2779951007 @default.
- W4250170566 hasConcept C2780130745 @default.
- W4250170566 hasConcept C28021979 @default.
- W4250170566 hasConcept C31705614 @default.
- W4250170566 hasConcept C502032728 @default.
- W4250170566 hasConcept C55493867 @default.
- W4250170566 hasConcept C68026918 @default.
- W4250170566 hasConcept C71924100 @default.
- W4250170566 hasConcept C86803240 @default.
- W4250170566 hasConcept C98274493 @default.
- W4250170566 hasConceptScore W4250170566C102230213 @default.
- W4250170566 hasConceptScore W4250170566C104317684 @default.
- W4250170566 hasConceptScore W4250170566C141035611 @default.
- W4250170566 hasConceptScore W4250170566C142724271 @default.
- W4250170566 hasConceptScore W4250170566C151484617 @default.
- W4250170566 hasConceptScore W4250170566C153911025 @default.
- W4250170566 hasConceptScore W4250170566C167844969 @default.
- W4250170566 hasConceptScore W4250170566C177907266 @default.
- W4250170566 hasConceptScore W4250170566C181199279 @default.
- W4250170566 hasConceptScore W4250170566C185592680 @default.
- W4250170566 hasConceptScore W4250170566C25498285 @default.
- W4250170566 hasConceptScore W4250170566C2777633098 @default.
- W4250170566 hasConceptScore W4250170566C2778896982 @default.
- W4250170566 hasConceptScore W4250170566C2779134260 @default.
- W4250170566 hasConceptScore W4250170566C2779951007 @default.
- W4250170566 hasConceptScore W4250170566C2780130745 @default.
- W4250170566 hasConceptScore W4250170566C28021979 @default.
- W4250170566 hasConceptScore W4250170566C31705614 @default.
- W4250170566 hasConceptScore W4250170566C502032728 @default.
- W4250170566 hasConceptScore W4250170566C55493867 @default.
- W4250170566 hasConceptScore W4250170566C68026918 @default.
- W4250170566 hasConceptScore W4250170566C71924100 @default.
- W4250170566 hasConceptScore W4250170566C86803240 @default.
- W4250170566 hasConceptScore W4250170566C98274493 @default.
- W4250170566 hasLocation W42501705661 @default.
- W4250170566 hasOpenAccess W4250170566 @default.
- W4250170566 hasPrimaryLocation W42501705661 @default.
- W4250170566 hasRelatedWork W101759737 @default.
- W4250170566 hasRelatedWork W1484195647 @default.
- W4250170566 hasRelatedWork W2009075843 @default.
- W4250170566 hasRelatedWork W2055931977 @default.
- W4250170566 hasRelatedWork W2055989116 @default.
- W4250170566 hasRelatedWork W2059050392 @default.
- W4250170566 hasRelatedWork W2090594357 @default.
- W4250170566 hasRelatedWork W2156788921 @default.
- W4250170566 hasRelatedWork W2172309362 @default.
- W4250170566 hasRelatedWork W2193504565 @default.
- W4250170566 hasVolume "15" @default.
- W4250170566 isParatext "false" @default.
- W4250170566 isRetracted "false" @default.
- W4250170566 workType "article" @default.