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- W4252801574 abstract "Abstract As an important saprophytic filamentous fungus, Aspergillus terreus is ubiquitously distributed, including soil rhizospheres and marine environments. Due to the prominent capabilities of bioconversion and biosynthesis, A. terreus has become attractive in biotechnical and pharmaceutical industry. In this work, an A. terreus strain, B12, was isolated from sponge in South China Sea, which demonstrated broad bacteriostatic effects against a variety of pathogenic bacteria. The whole genome was sequenced, showing a genetic richness of BGCs, which might underpin the metabolic plasticity and adaptive resilience for the strain. Genome mining identified 67 biosynthetic gene clusters (BGCs), among which, 6 gene clusters could allocate to known BGCs (100% identity), corresponding to diverse metabolites like clavaric acid, dihydroisoflavipucine /isoflavipucine, dimethylcoprogen, alternariol, aspterric acid and pyranonigrin E. However, instead of the putative compounds, several other products were obtained from the B12 fermentation, including terrein, butyrolactone I, terretonin A&E, acoapetaline B and epi-aszonalenins A. Of note, acoapetaline B and epi-aszonalenins A, discovered natural products recently with little information, unexpectedly were reported in this A. terreus strain. The genomic and heterogeneity observed in strain B12, should be at least partially attributed to the genetic variability and biochemical diversity of A. terreus , which could be an interesting issue open to future efforts." @default.
- W4252801574 created "2022-05-12" @default.
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- W4252801574 date "2021-05-25" @default.
- W4252801574 modified "2023-10-03" @default.
- W4252801574 title "Genome Mining of Secondary Metabolites From a Marine-derived Aspergillus Terreus B12" @default.
- W4252801574 doi "https://doi.org/10.21203/rs.3.rs-541300/v1" @default.
- W4252801574 hasPublicationYear "2021" @default.
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