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- W4254350769 abstract "TWO CLINICAL TRIALS based on blocking tumor-cell growth factors represent an approach that may transform the face of cancer chemotherapy within the next decade. The phase I studies now under way at the National Cancer Institute, Bethesda, Md, and Memorial Sloan-Kettering Cancer Center, New York City, involve antibodies to growth factors and their receptors. Because these agents intercede in a particular process in a particular type of tumor cell, they have potentially greater specificity and fewer side effects than the tumoricidal agents currently in use. Thus they may make it much easier to spare the patient<i>and</i>spoil the tumor. The first of these agents—a monoclonal antibody to gastrin-releasing peptide (GRP)—has been in phase I clinical trials for 18 months. The antibody, manufactured by Hybritech in San Diego, is raised to bombesin, a regulatory peptide isolated from frog skin. Bombesin is the amphibian analogue of GRP, which stimulates human bronchial" @default.
- W4254350769 created "2022-05-12" @default.
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- W4254350769 date "1988-02-19" @default.
- W4254350769 modified "2023-10-18" @default.
- W4254350769 title "Antibodies to tumor growth factors herald new era in chemotherapy" @default.
- W4254350769 doi "https://doi.org/10.1001/jama.259.7.957" @default.
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