FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280512557> ?p ?o ?g. }

• W4280512557 endingPage "e3001636" @default.
• W4280512557 startingPage "e3001636" @default.
• W4280512557 abstract "The recent revolution in computational protein structure prediction provides folding models for entire proteomes, which can now be integrated with large-scale experimental data. Mass spectrometry (MS)-based proteomics has identified and quantified tens of thousands of posttranslational modifications (PTMs), most of them of uncertain functional relevance. In this study, we determine the structural context of these PTMs and investigate how this information can be leveraged to pinpoint potential regulatory sites. Our analysis uncovers global patterns of PTM occurrence across folded and intrinsically disordered regions. We found that this information can help to distinguish regulatory PTMs from those marking improperly folded proteins. Interestingly, the human proteome contains thousands of proteins that have large folded domains linked by short, disordered regions that are strongly enriched in regulatory phosphosites. These include well-known kinase activation loops that induce protein conformational changes upon phosphorylation. This regulatory mechanism appears to be widespread in kinases but also occurs in other protein families such as solute carriers. It is not limited to phosphorylation but includes ubiquitination and acetylation sites as well. Furthermore, we performed three-dimensional proximity analysis, which revealed examples of spatial coregulation of different PTM types and potential PTM crosstalk. To enable the community to build upon these first analyses, we provide tools for 3D visualization of proteomics data and PTMs as well as python libraries for data accession and processing." @default.
• W4280512557 created "2022-05-22" @default.
• W4280512557 creator A5017081092 @default.
• W4280512557 creator A5023564164 @default.
• W4280512557 creator A5032874559 @default.
• W4280512557 creator A5033490134 @default.
• W4280512557 creator A5051709970 @default.
• W4280512557 creator A5063574912 @default.
• W4280512557 creator A5083069062 @default.
• W4280512557 creator A5090688128 @default.
• W4280512557 creator A5090940750 @default.
• W4280512557 date "2022-05-16" @default.
• W4280512557 modified "2023-10-14" @default.
• W4280512557 title "The structural context of posttranslational modifications at a proteome-wide scale" @default.
• W4280512557 cites W1484740038 @default.
• W4280512557 cites W1993548347 @default.
• W4280512557 cites W1996310767 @default.
• W4280512557 cites W1997835441 @default.
• W4280512557 cites W2006783212 @default.
• W4280512557 cites W2023096047 @default.
• W4280512557 cites W2039741753 @default.
• W4280512557 cites W2043274355 @default.
• W4280512557 cites W2061371173 @default.
• W4280512557 cites W2062114704 @default.
• W4280512557 cites W2078779212 @default.
• W4280512557 cites W2100908214 @default.
• W4280512557 cites W2101876702 @default.
• W4280512557 cites W2102025585 @default.
• W4280512557 cites W2118460316 @default.
• W4280512557 cites W2133465414 @default.
• W4280512557 cites W2144973278 @default.
• W4280512557 cites W2158217645 @default.
• W4280512557 cites W2168172687 @default.
• W4280512557 cites W2181523240 @default.
• W4280512557 cites W2288234278 @default.
• W4280512557 cites W2463195069 @default.
• W4280512557 cites W2519691041 @default.
• W4280512557 cites W2805587821 @default.
• W4280512557 cites W2806884808 @default.
• W4280512557 cites W2963950918 @default.
• W4280512557 cites W2994464657 @default.
• W4280512557 cites W3005045932 @default.
• W4280512557 cites W3022588515 @default.
• W4280512557 cites W3032221447 @default.
• W4280512557 cites W3096333766 @default.
• W4280512557 cites W3103145119 @default.
• W4280512557 cites W3104537585 @default.
• W4280512557 cites W3112873140 @default.
• W4280512557 cites W3119685635 @default.
• W4280512557 cites W3154372950 @default.
• W4280512557 cites W3159719254 @default.
• W4280512557 cites W3173752200 @default.
• W4280512557 cites W3176820067 @default.
• W4280512557 cites W3177828909 @default.
• W4280512557 cites W3183475563 @default.
• W4280512557 cites W3186179742 @default.
• W4280512557 cites W3198758357 @default.
• W4280512557 cites W3201963326 @default.
• W4280512557 cites W3202105508 @default.
• W4280512557 cites W3208408872 @default.
• W4280512557 cites W3211795435 @default.
• W4280512557 cites W3212912034 @default.
• W4280512557 doi "https://doi.org/10.1371/journal.pbio.3001636" @default.
• W4280512557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35576205" @default.
• W4280512557 hasPublicationYear "2022" @default.
• W4280512557 type Work @default.
• W4280512557 citedByCount "35" @default.
• W4280512557 countsByYear W42805125572022 @default.
• W4280512557 countsByYear W42805125572023 @default.
• W4280512557 crossrefType "journal-article" @default.
• W4280512557 hasAuthorship W4280512557A5017081092 @default.
• W4280512557 hasAuthorship W4280512557A5023564164 @default.
• W4280512557 hasAuthorship W4280512557A5032874559 @default.
• W4280512557 hasAuthorship W4280512557A5033490134 @default.
• W4280512557 hasAuthorship W4280512557A5051709970 @default.
• W4280512557 hasAuthorship W4280512557A5063574912 @default.
• W4280512557 hasAuthorship W4280512557A5083069062 @default.
• W4280512557 hasAuthorship W4280512557A5090688128 @default.
• W4280512557 hasAuthorship W4280512557A5090940750 @default.
• W4280512557 hasBestOaLocation W42805125571 @default.
• W4280512557 hasConcept C100631289 @default.
• W4280512557 hasConcept C104317684 @default.
• W4280512557 hasConcept C104397665 @default.
• W4280512557 hasConcept C119157956 @default.
• W4280512557 hasConcept C11960822 @default.
• W4280512557 hasConcept C120665830 @default.
• W4280512557 hasConcept C121332964 @default.
• W4280512557 hasConcept C151730666 @default.
• W4280512557 hasConcept C169822122 @default.
• W4280512557 hasConcept C181199279 @default.
• W4280512557 hasConcept C25602115 @default.
• W4280512557 hasConcept C2779343474 @default.
• W4280512557 hasConcept C34905852 @default.
• W4280512557 hasConcept C46111723 @default.
• W4280512557 hasConcept C55493867 @default.
• W4280512557 hasConcept C60644358 @default.
• W4280512557 hasConcept C70721500 @default.
• W4280512557 hasConcept C86803240 @default.

• next