Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290704805> ?p ?o ?g. }
- W4290704805 endingPage "157888" @default.
- W4290704805 startingPage "157888" @default.
- W4290704805 abstract "Metformin (MET) is among the most consumed drugs around the world, and thus, it is considered the uppermost drug in mass discharged into water settings. Nonetheless, data about the deleterious consequences of MET on water organisms are still scarce and require further investigation. Herein, we aimed to establish whether or not chronic exposure to MET (1, 20, and 40 μg/L) may alter the swimming behavior and induce neurotoxicity in Danio rerio adults. After 4 months of exposure, MET-exposed fish exhibited less swimming activity when compared to control fish. Moreover, compared with the control group, MET significantly inhibited the activity of AChE and induced oxidative damage in the brain of fish. Concerning gene expression, MET significantly upregulated the expression of Nrf1, Nrf2, BAX, p53, BACE1, APP, PSEN1, and downregulated CASP3 and CASP9. Although MET did not overexpress the CASP3 gene, we saw a meaningful rise in the activity of this enzyme in the blood of fish exposed to MET compared to the control group, which we then confirmed by a high number of apoptotic cells in the TUNEL assay. Our findings demonstrate that chronic exposure to MET may impair fish swimming behavior, making them more vulnerable to predators." @default.
- W4290704805 created "2022-08-09" @default.
- W4290704805 creator A5003775743 @default.
- W4290704805 creator A5032812469 @default.
- W4290704805 creator A5048738944 @default.
- W4290704805 creator A5060494311 @default.
- W4290704805 creator A5066709083 @default.
- W4290704805 creator A5070457304 @default.
- W4290704805 creator A5070796563 @default.
- W4290704805 creator A5086402904 @default.
- W4290704805 date "2022-11-01" @default.
- W4290704805 modified "2023-10-09" @default.
- W4290704805 title "Chronic exposure to realistic concentrations of metformin prompts a neurotoxic response in Danio rerio adults" @default.
- W4290704805 cites W1000208362 @default.
- W4290704805 cites W1268815675 @default.
- W4290704805 cites W1499080786 @default.
- W4290704805 cites W1508162082 @default.
- W4290704805 cites W1557712018 @default.
- W4290704805 cites W1590457525 @default.
- W4290704805 cites W1750690213 @default.
- W4290704805 cites W1950969465 @default.
- W4290704805 cites W1971048984 @default.
- W4290704805 cites W1976709591 @default.
- W4290704805 cites W1979100644 @default.
- W4290704805 cites W1980488703 @default.
- W4290704805 cites W1988821503 @default.
- W4290704805 cites W1996822183 @default.
- W4290704805 cites W1997003352 @default.
- W4290704805 cites W2011197018 @default.
- W4290704805 cites W2015626449 @default.
- W4290704805 cites W2022761216 @default.
- W4290704805 cites W2027015623 @default.
- W4290704805 cites W2033457291 @default.
- W4290704805 cites W2048893204 @default.
- W4290704805 cites W2055219455 @default.
- W4290704805 cites W2057434522 @default.
- W4290704805 cites W2060911425 @default.
- W4290704805 cites W2061333433 @default.
- W4290704805 cites W2075503719 @default.
- W4290704805 cites W2077283823 @default.
- W4290704805 cites W2077852011 @default.
- W4290704805 cites W2077854734 @default.
- W4290704805 cites W2079749054 @default.
- W4290704805 cites W2094156327 @default.
- W4290704805 cites W2105316032 @default.
- W4290704805 cites W2107277218 @default.
- W4290704805 cites W2108058238 @default.
- W4290704805 cites W2143681046 @default.
- W4290704805 cites W2147917643 @default.
- W4290704805 cites W2154472922 @default.
- W4290704805 cites W2196888533 @default.
- W4290704805 cites W2210167719 @default.
- W4290704805 cites W2277146103 @default.
- W4290704805 cites W2277565015 @default.
- W4290704805 cites W2314605806 @default.
- W4290704805 cites W2317714996 @default.
- W4290704805 cites W2491034915 @default.
- W4290704805 cites W2519786994 @default.
- W4290704805 cites W2557513796 @default.
- W4290704805 cites W2604318154 @default.
- W4290704805 cites W2746116728 @default.
- W4290704805 cites W2760088574 @default.
- W4290704805 cites W2789295379 @default.
- W4290704805 cites W2791113187 @default.
- W4290704805 cites W2801335333 @default.
- W4290704805 cites W2804416221 @default.
- W4290704805 cites W2804758746 @default.
- W4290704805 cites W2887248232 @default.
- W4290704805 cites W2890024477 @default.
- W4290704805 cites W2896647652 @default.
- W4290704805 cites W2905035856 @default.
- W4290704805 cites W2905716177 @default.
- W4290704805 cites W2910241669 @default.
- W4290704805 cites W2911493122 @default.
- W4290704805 cites W2945516613 @default.
- W4290704805 cites W2957602423 @default.
- W4290704805 cites W2971514915 @default.
- W4290704805 cites W307967064 @default.
- W4290704805 cites W3086747393 @default.
- W4290704805 cites W3110909094 @default.
- W4290704805 cites W3149245956 @default.
- W4290704805 cites W3179942245 @default.
- W4290704805 cites W3186256611 @default.
- W4290704805 cites W3191681572 @default.
- W4290704805 cites W3205324412 @default.
- W4290704805 cites W4205800804 @default.
- W4290704805 cites W4293247451 @default.
- W4290704805 cites W2805199739 @default.
- W4290704805 doi "https://doi.org/10.1016/j.scitotenv.2022.157888" @default.
- W4290704805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35952892" @default.
- W4290704805 hasPublicationYear "2022" @default.
- W4290704805 type Work @default.
- W4290704805 citedByCount "7" @default.
- W4290704805 countsByYear W42907048052022 @default.
- W4290704805 countsByYear W42907048052023 @default.
- W4290704805 crossrefType "journal-article" @default.
- W4290704805 hasAuthorship W4290704805A5003775743 @default.
- W4290704805 hasAuthorship W4290704805A5032812469 @default.