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• W4292589986 abstract "Peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) acts as a key factor in breast cancer metastasis. Notably, PPAR‑γ can inhibit metalloproteinase (MMP), which is involved in cancer metastasis. Our previous study revealed that PPAR‑γ was related to breast cancer metastasis. The present study aimed to investigate whether the PPAR‑γ ligand 2‑cyano‑3,12‑dioxooleana‑1,9‑dien‑28‑oic acid (CDDO) mediated suppression of cell invasion and reduced the expression of MMP‑9 in breast cancer cells. The results indicated that CDDO reduced MMP‑9 expression, cell migration and invasion of breast cancer cells by inhibiting TPA‑induced phosphorylation of mitogen‑activated protein kinases, and downregulating the activities of activator protein‑1 and nuclear factor κB. Notably, knock‑out of PPAR‑γ by small interfering RNA in MCF‑7 cells revealed that TPA‑induced MMP‑9 expression occurred through a PPAR‑γ‑independent pathway. These data indicated that the downregulatory effect of CDDO on MMP‑9 expression was affected by a mechanism independent of PPAR‑γ. In conclusion, the findings of the present study suggested that CDDO may act as a key agent in the regulation of breast cancer metastasis, suggesting CDDO as a new targeted therapy for breast cancer." @default.
• W4292589986 created "2022-08-22" @default.
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• W4292589986 date "2022-08-22" @default.
• W4292589986 modified "2023-10-14" @default.
• W4292589986 title "CDDO, a PPAR‑γ ligand, inhibits TPA‑induced cell migration and invasion through a PPAR‑γ‑independent mechanism" @default.
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• W4292589986 doi "https://doi.org/10.3892/ol.2022.13474" @default.
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